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FCGR3B copy number variation is not associated with lupus nephritis in a Chinese population
Lv, J.1,2; Yang, Y.1,2,3; Zhou, X.1,2; Yu, L.1,2; Li, R.3; Hou, P.1,2; Zhang, H.1,2
关键词Copy Number Variance Fcgr3b Genetics Lupus Nephritis
刊名LUPUS
2010-02-01
DOI10.1177/0961203309350319
19期:2页:158-161
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Rheumatology
研究领域[WOS]Rheumatology
关键词[WOS]GAMMA-RECEPTOR-IIB ; TIME QUANTITATIVE PCR ; FAMILY-BASED ASSOCIATION ; GENETIC SUSCEPTIBILITY ; ERYTHEMATOSUS ; POLYMORPHISMS ; AUTOIMMUNITY ; ASSAY ; SLE
英文摘要

Copy number variation (CNV) is common in genomic regions encoding immune-related genes and can impact polygenic autoimmunity. FCGR3B CNV is associated with susceptibility to systemic autoimmunity in Caucasian populations. In this study, we examined FCGR3B CNV in patients with the autoimmune disease lupus nephritis (LN) in a Chinese population. The study includes 202 patients with histologically verified LN and 146 geographically matched healthy controls. To identify CNV at the FCGRB locus, quantitative polymerase chain reaction (PCR) was done with TaqMan(TM) probes and relative copy number was estimated with relative quantitative 2(-Delta Delta Ct) method. The distribution of FCGR3B relative copy number did not differ significantly between the LN patients and the controls (1.17 +/- 0.42 for LN; 1.15 +/- 0.37 for controls; p = 0.627). The difference was still not significant when the data were stratified by gender. There was no significant difference when the LN patients were divided by pathological phenotype (proliferative LN compared with non-proliferative p = 0.511; AI < 12 compared with AI >= 12, p = 0.401; and chronicity index (CI) < 4 compared with CI >= 4, p = 0.058) or lupus disease activity index (SLEDAI <= 10 compared with SLEDAI > 10, p = 0.996). The data suggest that FCGR3B CNV was not associated with LN development or progression in this Chinese population. These results were surprising given the strong in a Caucasian population. Lupus (2010) 19, 158-161.

语种英语
WOS记录号WOS:000273792400005
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55192
专题北京大学精神卫生研究所_护理部
北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Div Renal, Hosp 1, Inst Nephrol,Dept Med, Beijing 100034, Peoples R China
2.Minist Hlth, Key Lab Renal Dis, Beijing, Peoples R China
3.Shanxi Med Univ, Div Renal, Hosp 2, Taiyuan, Peoples R China
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GB/T 7714
Lv, J.,Yang, Y.,Zhou, X.,et al. FCGR3B copy number variation is not associated with lupus nephritis in a Chinese population[J]. LUPUS,2010,19(2):158-161.
APA Lv, J..,Yang, Y..,Zhou, X..,Yu, L..,Li, R..,...&Zhang, H..(2010).FCGR3B copy number variation is not associated with lupus nephritis in a Chinese population.LUPUS,19(2),158-161.
MLA Lv, J.,et al."FCGR3B copy number variation is not associated with lupus nephritis in a Chinese population".LUPUS 19.2(2010):158-161.
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