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学科主题: 临床医学
题名:
FCGR3B copy number variation is not associated with lupus nephritis in a Chinese population
作者: Lv, J.1,2; Yang, Y.1,2,3; Zhou, X.1,2; Yu, L.1,2; Li, R.3; Hou, P.1,2; Zhang, H.1,2
关键词: copy number variance ; FCGR3B ; genetics ; lupus nephritis
刊名: LUPUS
发表日期: 2010-02-01
DOI: 10.1177/0961203309350319
卷: 19, 期:2, 页:158-161
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: GAMMA-RECEPTOR-IIB ; TIME QUANTITATIVE PCR ; FAMILY-BASED ASSOCIATION ; GENETIC SUSCEPTIBILITY ; ERYTHEMATOSUS ; POLYMORPHISMS ; AUTOIMMUNITY ; ASSAY ; SLE
英文摘要:

Copy number variation (CNV) is common in genomic regions encoding immune-related genes and can impact polygenic autoimmunity. FCGR3B CNV is associated with susceptibility to systemic autoimmunity in Caucasian populations. In this study, we examined FCGR3B CNV in patients with the autoimmune disease lupus nephritis (LN) in a Chinese population. The study includes 202 patients with histologically verified LN and 146 geographically matched healthy controls. To identify CNV at the FCGRB locus, quantitative polymerase chain reaction (PCR) was done with TaqMan(TM) probes and relative copy number was estimated with relative quantitative 2(-Delta Delta Ct) method. The distribution of FCGR3B relative copy number did not differ significantly between the LN patients and the controls (1.17 +/- 0.42 for LN; 1.15 +/- 0.37 for controls; p = 0.627). The difference was still not significant when the data were stratified by gender. There was no significant difference when the LN patients were divided by pathological phenotype (proliferative LN compared with non-proliferative p = 0.511; AI < 12 compared with AI >= 12, p = 0.401; and chronicity index (CI) < 4 compared with CI >= 4, p = 0.058) or lupus disease activity index (SLEDAI <= 10 compared with SLEDAI > 10, p = 0.996). The data suggest that FCGR3B CNV was not associated with LN development or progression in this Chinese population. These results were surprising given the strong in a Caucasian population. Lupus (2010) 19, 158-161.

语种: 英语
所属项目编号: 30801022 ; 30825021 ; 985-2-2007-113
项目资助者: National Natural Science Foundation of China ; Foundation of Ministry of Education of China
WOS记录号: WOS:000273792400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55192
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Div Renal, Hosp 1, Inst Nephrol,Dept Med, Beijing 100034, Peoples R China
2.Minist Hlth, Key Lab Renal Dis, Beijing, Peoples R China
3.Shanxi Med Univ, Div Renal, Hosp 2, Taiyuan, Peoples R China

Recommended Citation:
Lv, J.,Yang, Y.,Zhou, X.,et al. FCGR3B copy number variation is not associated with lupus nephritis in a Chinese population[J]. LUPUS,2010,19(2):158-161.
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