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IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤放疗科  > 期刊论文
学科主题: 临床医学
题名:
Long-Term Clinical Outcome of Intensity-Modulated Radiotherapy for Inoperable Non-Small Cell Lung Cancer: The MD Anderson Experience
作者: Jiang, Zhi-Qin5; Yang, Kunyu6; Komaki, Ritsuko; Wei, Xiong; Tucker, Susan L.3; Zhuang, Yan2; Martel, Mary K.2; Vedam, Sastray2; Balter, Peter2; Zhu, Guangying7; Gomez, Daniel; Lu, Charles4; Mohan, Radhe2; Cox, James D.; Liao, Zhongxing1
关键词: Non-small-cell lung cancer ; IMRT ; Early and late toxicity ; Radiation-induced toxicity
刊名: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
发表日期: 2012-05-01
DOI: 10.1016/j.ijrobp.2011.06.1963
卷: 83, 期:1, 页:332-339
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Oncology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: 3-DIMENSIONAL CONFORMAL RADIOTHERAPY ; TREATMENT-RELATED PNEUMONITIS ; CONCURRENT CHEMOTHERAPY ; SEQUENTIAL CHEMORADIOTHERAPY ; DOSE-ESCALATION ; TARGET VOLUME ; RADIATION ; TOXICITY
英文摘要:

Purpose: In 2007, we published our initial experience in treating inoperable non-small-cell lung cancer (NSCLC) with intensity-modulated radiation therapy (IMRT). The current report is an update of that experience with long-term follow-up.

Methods and Materials: Patients in this retrospective review were 165 patients who began definitive radiotherapy, with or without chemotherapy, for newly diagnosed, pathologically confirmed NSCLC to a dose of >= 60 Gy from 2005 to 2006. Early and late toxicities assessed included treatment-related pneumonitis (TRP), pulmonary fibrosis, esophagitis, and esophageal stricture, scored mainly according to the Common Terminology Criteria for Adverse Events 3.0. Other variables monitored were radiation-associated dermatitis and changes in body weight and Karnofsky performance status. The Kaplan-Meier method was used to compute survival and freedom from radiation-related acute and late toxicities as a function of time.

Results: Most patients (89%) had Stage III to IV disease. The median radiation dose was 66 Gy given in 33 fractions (range, 60-76 Gy, 1.8-2.3 Gy per fraction). Median overall survival time was 1.8 years; the 2-year and 3-year overall survival rates were 46% and 30%. Rates of Grade >= 3 maximum TRP (TRPmax) were 11% at 6 months and 14% at 12 months. At 18 months, 86% of patients had developed Grade >= 1 maximum pulmonary fibrosis (pulmonary fibrosis(max)) and 7% Grade >= 2 pulmonary fibrosis(max). The median times to maximum esophagitis (esophagitis(max)) were 3 weeks (range, 1-13 weeks) for Grade 2 and 6 weeks (range, 3-13 weeks) for Grade 3. A higher percentage of patients who experienced Grade 3 esophagitismax later developed Grade 2 to 3 esophageal stricture.

Conclusions: In our experience, using IMRT to treat NSCLC leads to low rates of pulmonary and esophageal toxicity, and favorable clinical outcomes in terms of survival. (C) 2012 Elsevier Inc.

语种: 英语
项目资助者: Department of Radiation Oncology, the University of Texas MD Anderson Cancer Center
WOS记录号: WOS:000302993900069
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55209
Appears in Collections:北京大学临床肿瘤学院_肿瘤放疗科_期刊论文

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作者单位: 1.Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Unit 97, Houston, TX 77030 USA
2.Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA
3.Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA
4.Univ Texas MD Anderson Canc Ctr, Dept Thorac Med Oncol, Houston, TX 77030 USA
5.Fudan Univ Shanghai Canc Ctr, Dept Radiat Oncol, Shanghai, Peoples R China
6.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Ctr Canc, Wuhan 430074, Peoples R China
7.Peking Univ Sch Oncol, Beiijng Canc Hosp & Inst, Dept Radiat Oncol, Beijing, Peoples R China

Recommended Citation:
Jiang, Zhi-Qin,Yang, Kunyu,Komaki, Ritsuko,et al. Long-Term Clinical Outcome of Intensity-Modulated Radiotherapy for Inoperable Non-Small Cell Lung Cancer: The MD Anderson Experience[J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,2012,83(1):332-339.
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