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学科主题: 临床医学
题名:
The nucleosome binding protein NSBP1 is highly expressed in human bladder cancer and promotes the proliferation and invasion of bladder cancer cells
作者: Wahafu, Wasilijiang1,2,3; He, Zhi-Song1,2,3; Zhang, Xiao-Yu1,2,3; Zhang, Cui-Jian1,2,3; Yao, Kun1,2,3; Hao, Han1,2,3; Song, Gang1,2,3; He, Qun1,2,3; Li, Xue-Song1,2,3; Zhou, Li-Qun1,2,3
关键词: Bladder cancer ; NSBP1 ; High mobility group proteins ; RNA interference
刊名: TUMOR BIOLOGY
发表日期: 2011-10-01
DOI: 10.1007/s13277-011-0195-0
卷: 32, 期:5, 页:931-939
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GROUP CHROMOSOMAL-PROTEINS ; REMODELING COMPLEXES ; OVARIAN-CARCINOMA ; GENE-REGULATION ; CHROMATIN ; DIFFERENTIATION ; TRANSCRIPTION ; DEACETYLASES ; STATISTICS ; GROWTH
英文摘要:

NSBP1 is a recently identified member of the HMGN protein family which binds to nucleosomes and regulates gene transcription through chromatin remodeling. In this study, we aimed to investigate the potential role of NSBP1 in human bladder cancer. We examined NSBP1 expression in 114 surgically removed bladder cancer specimens as well as 11 human bladder cell lines by immunohistochemistry and Western blot analysis, and found that NSBP1 level was correlated with the increased tumor grade and pathologic stage, and lymph node metastasis. RNAi-mediated knockdown of NSBP1 in EJ cells, a bladder cancer cell line that overexpressed NSBP1, resulted in moderate decrease of cell viability, moderate blockage of cell cycle at G2/M phase, and decreased cyclin B1 expression, but had no effects on apoptosis. Moreover, NSBP1 knockdown led to reduced activity of MMP-9 but not MMP-2. Taken together, these results suggest that NSBP1 promotes the viability of bladder cancer cells through increased cell proliferation but not decreased apoptosis, and increases the invasion ability of metastatic bladder cancer cells through the upregulation of MMP-9 activity. Our findings not only provide a molecular understanding of the role of NSBP1 in bladder cancer, but also suggest NSBP1 RNAi as a novel therapeutic approach for bladder cancer.

语种: 英语
所属项目编号: 30271295 ; 30672099 ; 7092101
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000293962800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55214
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Natl Urol Canc Ctr, Beijing 100034, Peoples R China
2.Peking Univ, Inst Urol, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Urol, Beijing 100871, Peoples R China

Recommended Citation:
Wahafu, Wasilijiang,He, Zhi-Song,Zhang, Xiao-Yu,et al. The nucleosome binding protein NSBP1 is highly expressed in human bladder cancer and promotes the proliferation and invasion of bladder cancer cells[J]. TUMOR BIOLOGY,2011,32(5):931-939.
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