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学科主题临床医学
Prevalence of human papillomavirus and cervical intraepithelial neoplasia in China: A pooled analysis of 17 population-based studies
Zhao, Fang-Hui2; Lewkowitz, Adam K.2,3; Hu, Shang-Ying2; Chen, Feng2; Li, Long-Yu4; Zhang, Qing-Ming5; Wu, Rui-Fang6; Li, Chang-Qing7; Wei, Li-Hui8; Xu, Ai-Di9; Zhang, Wen-Hua2; Pan, Qin-Jing2; Zhang, Xun2; Belinson, Jerome L.10,11; Sellors, John W.12,13; Smith, Jennifer S.14; Qiao, You-Lin1,2; Franceschi, Silvia15
关键词Cervical Cancer Human Papillomavirus Cervical Intraepithelial Neoplasia Prevalence China
刊名INTERNATIONAL JOURNAL OF CANCER
2012-12-15
DOI10.1002/ijc.27571
131期:12页:2929-2938
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者Fogarty International Center at the National Institutes of Health (Fogarty International Clinical Research Fellows Program at Vanderbilt University) ; Academic Capacity Development Program of Beijing Municipal Commission of Education ; MOH Special Research Grant ; Fogarty International Center at the National Institutes of Health through the Fogarty International Clinical Research Fellows Program at Vanderbilt University ; Academic Capacity Development Program of Beijing Municipal Commission of Education ; MOH Special Research Grant ; Preventive Oncology International ; Fogarty International Center at the National Institutes of Health (Fogarty International Clinical Research Fellows Program at Vanderbilt University) ; Academic Capacity Development Program of Beijing Municipal Commission of Education ; MOH Special Research Grant ; Fogarty International Center at the National Institutes of Health through the Fogarty International Clinical Research Fellows Program at Vanderbilt University ; Academic Capacity Development Program of Beijing Municipal Commission of Education ; MOH Special Research Grant ; Preventive Oncology International
研究领域[WOS]Oncology
关键词[WOS]REPUBLIC-OF-CHINA ; SHANXI PROVINCE ; CANCER ; INFECTION ; RISK ; WOMEN ; HPV ; PERSISTENCE ; STRATEGIES ; WORLDWIDE
英文摘要

High-risk (HR) human papillomavirus (HPV) prevalence has been shown to correlate well with cervical cancer incidence rates. Our study aimed to estimate the prevalence of HR-HPV and cervical intraepithelial neoplasia (CIN) in China and indirectly informs on the cervical cancer burden in the country. A total of 30,207 women from 17 population-based studies throughout China were included. All women received HPV DNA testing (HC2, Qiagen, Gaithersburg, MD), visual inspection with acetic acid and liquid-based cytology. Women positive for any test received colposcopy-directed or four-quadrant biopsies. A total of 29,579 women had HR-HPV testing results, of whom 28,761 had biopsy confirmed (9,019, 31.4%) or assumed (19,742, 68.6%) final diagnosis. Overall crude HR-HPV prevalence was 17.7%. HR-HPV prevalence was similar in rural and urban areas but showed dips in different age groups: at age 2529 (11.3%) in rural and at age 3539 (11.3%) in urban women. In rural and urban women, age-standardized CIN2 prevalence was 1.5% [95% confidence interval (CI): 1.41.6%] and 0.7% (95% CI: 0.70.8%) and CIN3+ prevalence was 1.2% (95% CI: 1.21.3%) and 0.6% (95% CI: 0.50.7%), respectively. Prevalence of CIN3+ as a percentage of either all women or HR-HPV-positive women steadily increased with age, peaking in 45- to 49-year-old women. High prevalence of HR-HPV and CIN3+ was detected in both rural and urban China. The steady rise of CIN3+ up to the age group of 4549 is attributable to lack of lesion removal through screening. Our findings document the inadequacy of current screening in China while indirectly raising the possibility that the cervical cancer burden in China is underreported.

语种英语
所属项目编号R24 TW007988 ; XK100230447 ; 200902002
资助者Fogarty International Center at the National Institutes of Health (Fogarty International Clinical Research Fellows Program at Vanderbilt University) ; Academic Capacity Development Program of Beijing Municipal Commission of Education ; MOH Special Research Grant ; Fogarty International Center at the National Institutes of Health through the Fogarty International Clinical Research Fellows Program at Vanderbilt University ; Academic Capacity Development Program of Beijing Municipal Commission of Education ; MOH Special Research Grant ; Preventive Oncology International ; Fogarty International Center at the National Institutes of Health (Fogarty International Clinical Research Fellows Program at Vanderbilt University) ; Academic Capacity Development Program of Beijing Municipal Commission of Education ; MOH Special Research Grant ; Fogarty International Center at the National Institutes of Health through the Fogarty International Clinical Research Fellows Program at Vanderbilt University ; Academic Capacity Development Program of Beijing Municipal Commission of Education ; MOH Special Research Grant ; Preventive Oncology International
WOS记录号WOS:000310482300022
引用统计
被引频次:54[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55215
专题北京大学深圳医院
作者单位1.Mt Sinai Sch Med, Dept Med Educ, New York, NY USA
2.Gansu Prov Canc Hosp, Dept Gynecol Oncol, Lanzhou, Gansu, Peoples R China
3.Hongkou Dist Hlth Bur, Shanghai, Peoples R China
4.Prevent Oncol Int Inc, Cleveland, OH USA
5.PATH, Seattle, WA USA
6.McMaster Univ, Hamilton, ON, Canada
7.Int Agcy Res Canc, Sect Infect, F-69372 Lyon, France
8.Chinese Acad Med Sci, Canc Inst Hosp, Dept Canc Epidemiol, Beijing 100021, Peoples R China
9.Peking Union Med Coll, Beijing 100021, Peoples R China
10.Jiangxi Prov Women & Children Hosp, Dept Obstet & Gynecol, Nanchang, Jiangxi, Peoples R China
11.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen, Guangdong, Peoples R China
12.Xinmi City Women & Children Hosp, Xinmi City, Henan Province, Peoples R China
13.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
14.Cleveland Clin, Dept Obstet & Gynecol, Cleveland, OH 44106 USA
15.Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA
推荐引用方式
GB/T 7714
Zhao, Fang-Hui,Lewkowitz, Adam K.,Hu, Shang-Ying,et al. Prevalence of human papillomavirus and cervical intraepithelial neoplasia in China: A pooled analysis of 17 population-based studies[J]. INTERNATIONAL JOURNAL OF CANCER,2012,131(12):2929-2938.
APA Zhao, Fang-Hui.,Lewkowitz, Adam K..,Hu, Shang-Ying.,Chen, Feng.,Li, Long-Yu.,...&Franceschi, Silvia.(2012).Prevalence of human papillomavirus and cervical intraepithelial neoplasia in China: A pooled analysis of 17 population-based studies.INTERNATIONAL JOURNAL OF CANCER,131(12),2929-2938.
MLA Zhao, Fang-Hui,et al."Prevalence of human papillomavirus and cervical intraepithelial neoplasia in China: A pooled analysis of 17 population-based studies".INTERNATIONAL JOURNAL OF CANCER 131.12(2012):2929-2938.
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