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Pharmacokinetics and Treatment Efficacy of Camptothecin Nanocrystals on Lung Metastasis
Zhang, Hua1; Wang, Xueqing1; Dai, Wenbing1; Gemeinhart, Richard A.2,3,4; Zhang, Qiang1; Li, Tonglei5
关键词Camptothecin Pharmacokinetics Metastasis Nanocrystals Drug Delivery
刊名MOLECULAR PHARMACEUTICS
2014
DOI10.1021/mp4004018
11期:1页:226-233
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]IN-VIVO ; CARBOXYLATE FORMS ; ANTITUMOR ; NANOPARTICLES ; INHIBITION ; DELIVERY ; LACTONE ; GROWTH ; AGENTS ; TUMORS
英文摘要

Cancer metastasis is difficult to treat, and its outcome becomes dreadful for a patient. Lung is a major metastatic site for many types of cancers, and the need for finding effective treatment for lung metastasis cannot be overemphasized. In a previous study, we showed that camptothecin nanocrystals demonstrated greater anticancer, efficacy and achieved significantly higher concentration in lungs than a conventional, solution-based formulation., In this study, we further determined the pharmacokinetics of camptothecin nanocrystals in rats and investigated treatment efficacy in mice against metastatic lung tumors. The results show that camptothecin nanocrystals were capable of eliciting greater antimetastatic efficacy and achieve a longer survival time in the murine model compared with camptothecin salt solution. The study suggests that using engineered, solid nanoparticles may be a feasible approach in the treatment of lung cancer and lung metastatic cancer.

语种英语
WOS记录号WOS:000329529700021
项目编号81202470 ; 81130059 ; 2009CB930300 ; BC050287
资助机构National Natural Science Foundation of China ; National Research Fund for Fundamental Key Project ; DOD BCRP
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55217
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Univ Illinois, Dept Biopharmaceut Sci, Chicago, IL 60612 USA
3.Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA
4.Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA
5.Purdue Univ, Sch Pharm, Dept Ind & Phys Pharm, W Lafayette, IN 47907 USA
推荐引用方式
GB/T 7714
Zhang, Hua,Wang, Xueqing,Dai, Wenbing,et al. Pharmacokinetics and Treatment Efficacy of Camptothecin Nanocrystals on Lung Metastasis[J]. MOLECULAR PHARMACEUTICS,2014,11(1):226-233.
APA Zhang, Hua,Wang, Xueqing,Dai, Wenbing,Gemeinhart, Richard A.,Zhang, Qiang,&Li, Tonglei.(2014).Pharmacokinetics and Treatment Efficacy of Camptothecin Nanocrystals on Lung Metastasis.MOLECULAR PHARMACEUTICS,11(1),226-233.
MLA Zhang, Hua,et al."Pharmacokinetics and Treatment Efficacy of Camptothecin Nanocrystals on Lung Metastasis".MOLECULAR PHARMACEUTICS 11.1(2014):226-233.
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