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学科主题: 药学
题名:
Pharmacokinetics and Treatment Efficacy of Camptothecin Nanocrystals on Lung Metastasis
作者: Zhang, Hua1; Wang, Xueqing1; Dai, Wenbing1; Gemeinhart, Richard A.2,3,4; Zhang, Qiang1; Li, Tonglei5
关键词: camptothecin ; pharmacokinetics ; metastasis ; nanocrystals ; drug delivery
刊名: MOLECULAR PHARMACEUTICS
发表日期: 2014
DOI: 10.1021/mp4004018
卷: 11, 期:1, 页:226-233
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: IN-VIVO ; CARBOXYLATE FORMS ; ANTITUMOR ; NANOPARTICLES ; INHIBITION ; DELIVERY ; LACTONE ; GROWTH ; AGENTS ; TUMORS
英文摘要:

Cancer metastasis is difficult to treat, and its outcome becomes dreadful for a patient. Lung is a major metastatic site for many types of cancers, and the need for finding effective treatment for lung metastasis cannot be overemphasized. In a previous study, we showed that camptothecin nanocrystals demonstrated greater anticancer, efficacy and achieved significantly higher concentration in lungs than a conventional, solution-based formulation., In this study, we further determined the pharmacokinetics of camptothecin nanocrystals in rats and investigated treatment efficacy in mice against metastatic lung tumors. The results show that camptothecin nanocrystals were capable of eliciting greater antimetastatic efficacy and achieve a longer survival time in the murine model compared with camptothecin salt solution. The study suggests that using engineered, solid nanoparticles may be a feasible approach in the treatment of lung cancer and lung metastatic cancer.

语种: 英语
所属项目编号: 81202470 ; 81130059 ; 2009CB930300 ; BC050287
项目资助者: National Natural Science Foundation of China ; National Research Fund for Fundamental Key Project ; DOD BCRP
WOS记录号: WOS:000329529700021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55217
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Univ Illinois, Dept Biopharmaceut Sci, Chicago, IL 60612 USA
3.Univ Illinois, Dept Bioengn, Chicago, IL 60612 USA
4.Univ Illinois, Dept Ophthalmol & Visual Sci, Chicago, IL 60612 USA
5.Purdue Univ, Sch Pharm, Dept Ind & Phys Pharm, W Lafayette, IN 47907 USA

Recommended Citation:
Zhang, Hua,Wang, Xueqing,Dai, Wenbing,et al. Pharmacokinetics and Treatment Efficacy of Camptothecin Nanocrystals on Lung Metastasis[J]. MOLECULAR PHARMACEUTICS,2014,11(1):226-233.
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