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Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates
Zhao, Gengli1; Xu, Guobin1; Zhou, Min1; Jiang, Yaping1; Richards, Blair2; Clark, Katy M.2; Kaciroti, Niko2; Georgieff, Michael K.4; Zhang, Zhixiang1; Tardif, Twila2; Li, Ming1; Lozoff, Betsy2,3
关键词Pregnant Women Neonates Iron Supplementation Iron Deficiency Iron Deficiency Anemia Randomized Clinical Trial
刊名JOURNAL OF NUTRITION
2015-08-01
DOI10.3945/jn.114.208678
145期:8页:1916-1923
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]SERUM TRANSFERRIN RECEPTOR ; MICRONUTRIENT SUPPLEMENTATION ; PREGNANT-WOMEN ; BIRTH-WEIGHT ; CHILDREN ; OUTCOMES ; CONSEQUENCES ; NUTRITION ; PLACENTA ; TRENDS
英文摘要

Background: Previous trials of prenatal iron supplementation had limited measures of maternal or neonatal iron status.

Objective: The purpose was to assess effects of prenatal iron-folate supplementation on maternal and neonatal iron status.

Methods: Enrollment occurred June 2009 through December 2011 in Hebei, China. Women with uncomplicated singleton pregnancies at <= 20 wk gestation, aged >= 18 y, and with hemoglobin >= 100 g/L were randomly assigned ′1 :1 to receive daily iron (300 mg ferrous sulfate) or placebo + 0.40 mg folate from enrollment to birth. Iron status was assessed in maternal venous blood (at enrollment and at or near term) and cord blood. Primary outcomes were as follows: 1) maternal iron deficiency (ID) defined in 2 ways as serum ferritin (SF) <15 mu g/L and body iron (BI) <0 mg/kg; 2) maternal ID anemia [ID + anemia (IDA); hemoglobin <110 g/L]; and 3) neonatal ID (cord blood ferritin <75 mu g/L or zinc protoporphyrin/heme >118 mu mol/mol).

Results: A total of 2371 women were randomly assigned, with outcomes for 1632 women or neonates 1809 placebo/folate, 823 iron/folate; 1579 mother-newborn pairs, 37 mothers, 16 neonates). Most infants (97%) were born at term. At or near term, maternal hemoglobin was significantly higher (+5.56 g/L) for iron vs. placebo groups. Anemia risk was reduced (RR: 0.53; 95% Cl: 0.43, 0.66), as were risks of ID (RR: 0.74; 95% Cl: 0.69, 0.79 by SF; RR: 0.65; 95% CI: 0.59, 0.71 by BI) and IDA (RR: 0.49; 95% CI: 0.38, 0.62 by SF; RR: 0.51; 95% Cl: 0.40, 0.65 by BI). Most women still had ID (66.8% by SF, 54.7% by BD. Adverse effects, all minor, were similar by group. There were no differences in cord blood iron measures; >45% of neonates in each group had ID. However, dose-response analyses showed higher cord SF with more maternal iron capsules reported being consumed (beta per 10 capsules = 2:60, P < 0.05).

Conclusions: Prenatal iron supplementation reduced anemia, ID, and IDA in pregnant women in rurql ghina, but most women and >45% of neonates had ID, regardless of supplementation. This trial was registered at clinicaltnals.gov as NCT02221752.

语种英语
WOS记录号WOS:000359037500031
资助机构NIH
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55220
专题北京大学第一临床医学院
北京大学第一临床医学院_妇产科
作者单位1.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
2.Univ Michigan, Ctr Human Growth & Dev, Ann Arbor, MI 48109 USA
3.Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA
4.Univ Minnesota, Dept Pediat, Minneapolis, MN 55455 USA
推荐引用方式
GB/T 7714
Zhao, Gengli,Xu, Guobin,Zhou, Min,et al. Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates[J]. JOURNAL OF NUTRITION,2015,145(8):1916-1923.
APA Zhao, Gengli.,Xu, Guobin.,Zhou, Min.,Jiang, Yaping.,Richards, Blair.,...&Lozoff, Betsy.(2015).Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates.JOURNAL OF NUTRITION,145(8),1916-1923.
MLA Zhao, Gengli,et al."Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates".JOURNAL OF NUTRITION 145.8(2015):1916-1923.
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