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学科主题: 临床医学
题名:
Polymorphisms of interferon-inducible genes OAS associated with interferon-alpha treatment response in chronic HBV infection
作者: Ren, Shan1; Yu, Haibin1; Zhang, Hongwei1; Liu, Ying2; Huang, Yanxiang1; Ma, Lina1; Wei, Lai3; Wu, Hao1; Chen, Xinyue1
关键词: Hepatitis B virus (HBV) ; Interferon-alpha ; HBsAg seroconversion ; Single nucleotide polymorphism (SNP) ; 2 &prime ; ,5 &prime ; -Oligoadenylate synthetase(OAS) ; Haplotype
刊名: ANTIVIRAL RESEARCH
发表日期: 2011-03-01
DOI: 10.1016/j.antiviral.2011.01.006
卷: 89, 期:3, 页:232-237
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Virology
研究领域[WOS]: Pharmacology & Pharmacy ; Virology
关键词[WOS]: CHRONIC HEPATITIS-B ; SINGLE-NUCLEOTIDE POLYMORPHISM ; SURFACE-ANTIGEN ; VIRUS-INFECTION ; SYNTHETASE ; MXA ; INDUCTION ; PATHWAY ; HBSAG
英文摘要:

\ To evaluate the role of host single nucleotide polymorphisms (SNPs) of 2′,5′-oligoadenylate synthetase (OAS) in predicting IFN response in patients with HBV infection, OAS gene and four SNPs were examined in 363 patients with chronic HBV infection (including 41 patients with HBsAg seroconversion) and 57 healthy controls. One SNP and three haplotypes were identified after adjustment for age, sex, HBV DNA. The frequency of OAS3T/C heterozygotes is 52.2% in responders (R) and 38.2% in non-responders (NR), with an odds ratio (OR) of 1.511 (P=0.018). For complete responders (CR) and NR, the OR reached 2.323(P=0.023). Haplotype analyses revealed significant association between three OAS haplotypes and response to IFN-alpha treatment. Genotype combination and interaction between gene-gene analyses disclosed that there was a positive interaction between OAS2/OAS3 and OAS3/OASL, and the rate of OR was 2.46 (likelihood test. P = 0.004) and 4.46 (likelihood test, P = 0.004), respectively. Our results suggest that OAS gene variations may play an important role in response to IFN-alpha and provide a novel strategy for the resolution of HBV infection. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2008ZX10002-013 ; 2008ZX10002-004 ; 2006AA02A410
项目资助者: National Eleventh Five-year Science and Technology Major Projects, China ; National High Technology Research and Development Program of China (863Program)
WOS记录号: WOS:000288928000007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55223
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Youan Hosp, Beijing 100069, Peoples R China
2.Chinese Acad Med Sci, Natl Lab Med Mol Biol, Inst Basic Med Sci, Peking Union Med Coll,Sch Basic Med, Beijing 100005, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Ren, Shan,Yu, Haibin,Zhang, Hongwei,et al. Polymorphisms of interferon-inducible genes OAS associated with interferon-alpha treatment response in chronic HBV infection[J]. ANTIVIRAL RESEARCH,2011,89(3):232-237.
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