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学科主题: 临床医学
题名:
Effect of interval after surgery on in vitro fertilization/intracytoplasmic sperm injection outcomes in patients with stage III/IV endometriosis
作者: Huang Xiao-wu1,2; Qiao Jie1; Xia En-lan2; Ma Yan-min3; Wang Ying1
关键词: endometriosis ; infertility ; fertilization in vitro ; surgery
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-08-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.16.003
卷: 123, 期:16, 页:2176-2180
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: LAPAROSCOPIC CYSTECTOMY ; FERTILIZATION ; INFERTILITY ; RECURRENCE ; RATES ; WOMEN
英文摘要:

Background For patients with severe endometriosis, the spontaneous pregnancy rates have been reported to be near 0 due to extreme distortion of normal pelvic anatomy Surgery is one of the treatment options; however, if patients failed to conceive after surgery, in vitro fertilization (IVF) is effective. The objective of this retrospective study was to determine the clinical characteristics of IVF/intracytoplasmic sperm injection (ICSI) in patients with stage III/IV endometriosis, and to determine the impact of the interval from surgery to IVF/ICSI on outcome

Methods One hundred and sixty patients who were diagnosed with stage III/1V endometriosis underwent IVF/ICSI cycles between February 2004 and June 2009 were enrolled The mean interval from surgery to IVF, number of oocytes retrieved, fertilization rate, implantation rate, embryos transferred, and good embryos transferred were compared between two age groups (<= 35 years and > 35 years)

Results The mean interval from surgery to IVF was (37 9 +/- 28.9) months for the group 5 35 years of age and (57 6 +/- 39.7) months for the group >35 years of age Twenty-five IVF/ICSI cycles (12 8%) were performed during the first year after surgery, and 34 9% IVF/ICSI cycles were performed 2 years after surgery No significant differences existed between the two groups with respect to the fertilization rate, implantation rate, number of embryos transferred, number of good embryos, clinical pregnancy rates, live birth rates, and cumulative clinical pregnancy rates (P >0 05). The probability of cumulative clinical pregnancies was 75%, 50%, and 25% ((29 0 +/- 4.8), (61.0 +/- 7.6), and (120 0 +/- 16.9) months after surgery, respectively).

Conclusions For infertile patients with stage III/IV endometriosis, the optimal time to conceive by IVF/ICSI is <2 years after surgery; nevertheless, most of the patients took a longer time to conceive.

语种: 英语
WOS记录号: WOS:000281488300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55224
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing 100191, Peoples R China
2.Fuxing Hosp Affiliated Capital Med Univ, Hysteroscop Ctr, Beijing 100038, Peoples R China
3.Capital Med Univ, Reprod Med Ctr, Beijing Obstet & Gynecol Hosp Affiliated, Beijing 100026, Peoples R China

Recommended Citation:
Huang Xiao-wu,Qiao Jie,Xia En-lan,et al. Effect of interval after surgery on in vitro fertilization/intracytoplasmic sperm injection outcomes in patients with stage III/IV endometriosis[J]. CHINESE MEDICAL JOURNAL,2010,123(16):2176-2180.
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