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学科主题: 临床医学
题名:
PRAME and WT1 transcripts constitute a good molecular marker combination for monitoring minimal residual disease in myelodysplastic syndromes
作者: Qin, Ya-Zhen; Zhu, Hong-Hu; Liu, Yan-Rong; Wang, Ya-Zhe; Shi, Hong-Xia; Lai, Yue-Yun; Xu, Lan-Ping; Liu, Dai-Hong; Jiang, Qian; Li, Ling-Di; Jiang, Bin; Liu, Kai-Yan; Huang, Xiao-Jun
关键词: Myelodysplastic syndromes ; PRAME transcript levels ; WT1 transcript levels ; minimal residual disease ; hematopoietic stem cell transplant
刊名: LEUKEMIA & LYMPHOMA
发表日期: 2013-07-01
DOI: 10.3109/10428194.2012.743656
卷: 54, 期:7, 页:1442-1449
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: ACUTE MYELOID-LEUKEMIA ; STEM-CELL TRANSPLANTATION ; TUMOR GENE WT1 ; SCORING SYSTEM ; EXPRESSION ; PROGNOSIS ; BIOLOGY ; RELAPSE ; AML
英文摘要:

PRAME and WT1 transcript levels were simultaneously measured in 312 bone marrow samples collected from patients with newly diagnosed myelodysplastic syndromes (MDS) and 111 samples collected during the treatment of 17 patients. Both the positive rate and the > 1-log increase expression frequency of PRAME were similar to those of WT1 (74.4 % vs. 77.6%; 51.6% vs. 49.0%), and 88.1% of patients overexpressed at least one marker. Moreover, the frequencies of PRAME expression with higher degrees of increase were significantly higher compared with those of WT1 expression (> 2-log increase: 30.8% vs. 3.8%; > 3-log increase: 9.0% vs. 0%; all p < 0.001). PRAME had a higher log increase than WT1 in 53.3% of the patients with overexpressed WT1. Both PRAME and WT1 transcript levels generally fluctuated within the normal range after hematopoietic stem cell transplant in all 10 patients in continuous complete remission. Six out of seven patients were predicted relapse by the combined detection: sustained positivity, or significant increase to be positive for both WT1 and PRAME in three patients, earlier by PRAME than WT1 or by PRAME alone in three patients. Thus, PRAME and WT1 transcripts constitute a good molecular marker combination for monitoring minimal residual disease in MDS.

语种: 英语
所属项目编号: 81170483
项目资助者: Nature Science Foundation of China
WOS记录号: WOS:000320698300019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55225
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Qin, Ya-Zhen,Zhu, Hong-Hu,Liu, Yan-Rong,et al. PRAME and WT1 transcripts constitute a good molecular marker combination for monitoring minimal residual disease in myelodysplastic syndromes[J]. LEUKEMIA &amp; LYMPHOMA,2013,54(7):1442-1449.
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