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Enhanced interaction among ErbB4, PSD-95 and NMDAR by chronic MK-801 treatment is associated with behavioral abnormalities
Li, Ji-Tao; Feng, Yu; Su, Yun-Ai; Wang, Xiao-Dong; Si, Tian-Mei
关键词Erbb4 Immunoprecipitation Nmda Receptor Nrg1 Schizophrenia
刊名PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
2013-07-01
DOI10.1016/j.pbb.2013.04.008
108页:44-53
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]INDUCED COGNITIVE DEFICITS ; SPATIAL WORKING-MEMORY ; PREFRONTAL CORTEX ; RECEPTOR HYPOFUNCTION ; PREPULSE INHIBITION ; GENE-EXPRESSION ; PHENCYCLIDINE-TREATMENT ; CONTEXT RECOGNITION ; SIGNALING PATHWAYS ; WILD-TYPE
英文摘要

The neuregulin1 (NRG1)-ErbB4 signaling pathway has been implicated in the pathophysiology of schizophrenia. Recent studies suggest that this pathway may interact with the N-methyl-D-aspartate receptor (NMDAR) via the postsynaptic scaffold protein PSD-95. This interaction is of particular interest given the leading role of the NMDAR hypofunction in schizophrenia. The present study investigated the short- and long-term effects of chronic NMDAR blockade on the functional interaction between the two systems in rat prefrontal cortex and hippocampus using immunoprecipitation. Adult male Wistar rats were treated intraperitoneally with MK-801 (0.25 mg/kg) or saline for 28 days. Twenty-four hours after the last injection, the associations of ErbB4 with PSD-95 and NMDAR were enhanced in the prefrontal cortex, whereas only phosphorylated-ErbB4 relative to ErbB4 was increased in the hippocampus. These effects, however, were not detectable 12 days after the last MK-801 treatment, indicating the reversible nature of these changes. We also investigated the effects of chronic MK-801 treatment on locomotion, prepulse inhibition, recognition memory, and spatial working memory. The results showed that this treatment led to decreased locomotor activity, reduced exploration in the center arena, and elevated startle magnitudes, indicating an anxiety-like phenotype. Taken together, our findings suggest that the NRG1-ErbB4 signaling could be modulated by repeated NMDAR blockade, and provide further evidence for the cross-talk between the two signaling pathways. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000321232800005
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55229
Collection北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
北京大学精神卫生研究所_药理室
作者单位Peking Univ, Inst Mental Hlth, Dept Psychopharmacol, Key Lab Mental Hlth,Minist Mental Hlth, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Li, Ji-Tao,Feng, Yu,Su, Yun-Ai,et al. Enhanced interaction among ErbB4, PSD-95 and NMDAR by chronic MK-801 treatment is associated with behavioral abnormalities[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2013,108:44-53.
APA Li, Ji-Tao,Feng, Yu,Su, Yun-Ai,Wang, Xiao-Dong,&Si, Tian-Mei.(2013).Enhanced interaction among ErbB4, PSD-95 and NMDAR by chronic MK-801 treatment is associated with behavioral abnormalities.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,108,44-53.
MLA Li, Ji-Tao,et al."Enhanced interaction among ErbB4, PSD-95 and NMDAR by chronic MK-801 treatment is associated with behavioral abnormalities".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 108(2013):44-53.
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