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学科主题: 药学
题名:
A new 1, 10-secoguaianolide from the aerial parts of Artemisia anomala
作者: Zan Ke1; Chen Xiao-Qing2; Tu Peng-Fei1
关键词: Artemisia anomala ; Chemical constituents ; 1, 10-secoguaianolides ; structure elucidation
刊名: CHINESE JOURNAL OF NATURAL MEDICINES
发表日期: 2012-09-01
DOI: 10.3724/SP.J.1009.2012.00358
卷: 10, 期:5, 页:358-362
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Integrative & Complementary Medicine ; Pharmacology & Pharmacy
关键词[WOS]: SESQUITERPENE LACTONES ; DERIVATIVES
英文摘要:

AIM: To study chemical constituents of the aerial parts of Artemisia anomala (Asteraceae). METHODS: The constituents were isolated with silica gel, ODS column chromatography and semi-preparative HPLC, and their structures were elucidated on the basis of physical characteristics and spectral data. RESULTS: Eight compounds were obtained, and their structures were identified as 3 beta-ethoxytanapartholide (1), (4S*, 5S*)-dihydro-5-[( 1R*, 2S*)-2-hydroxy-2-methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-(3-oxobutyl)-2(3H)-furanone (2), ligucyperonol (3), cyperusol C (4), santamarin (5), 1 alpha, 2 alpha, 3 alpha, 4 alpha, 10 alpha -pentahydroxyguaia-11(13)-ene-12, 6 alpha-olide (6), balanophonin (7), methyl 3-(2′-hydroxy-4′-methoxyphenyl) propanoate (8). CONCLUSION: Compound 1 was a new artifact, 4 and 8 were isolated from the genus Artemisia for the first time, and compounds 2-3, 5-7 were isolated from this plant for the first time.

语种: 英语
所属项目编号: 30973629 ; 20110490251 ; K20120213 ; 11ZYH08
项目资助者: National Natural Science Foundation of China ; China Post-doctoral Science Foundation ; Foundation of State Key Laboratory of Natural and Biomimetic Drugs in Peking University ; Capital TCM &amp ; Nursing Foundation
WOS记录号: WOS:000309035800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55236
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China

Recommended Citation:
Zan Ke,Chen Xiao-Qing,Tu Peng-Fei. A new 1, 10-secoguaianolide from the aerial parts of Artemisia anomala[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2012,10(5):358-362.
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