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学科主题: 临床医学
题名:
Genome editing in induced pluripotent stem cells
作者: Cheng, Li-Tao1,2; Sun, Liang-Tso1; Tada, Takashi1
刊名: GENES TO CELLS
发表日期: 2012-06-01
DOI: 10.1111/j.1365-2443.2012.01599.x
卷: 17, 期:6, 页:431-438
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Genetics & Heredity
研究领域[WOS]: Cell Biology ; Genetics & Heredity
关键词[WOS]: ZINC-FINGER NUCLEASES ; TARGETED GENE CORRECTION ; STRAND BREAK REPAIR ; HOMOLOGOUS RECOMBINATION ; MAMMALIAN-CELLS ; SOMATIC-CELLS ; EFFICIENT ; PATIENT ; SYSTEM ; GENERATION
英文摘要:

The discovery of induced pluripotent stem (iPS) cells has broadened the promises of regenerative medicine through the generation of syngeneic replacement cells or tissues via the differentiation of patient-specific iPS cells. To apply iPS cell-mediated therapy to patients with genetic disorders, however, genome-editing technologies with high efficiency and specificity are needed. Recently, several targeted genome-editing strategies mediated by zinc finger nuclease and transcription activator-like effector nuclease have been applied to human and mouse iPS cells. Furthermore, spontaneous homologous recombination can restore genotype to wild type in mouse iPS cells heterozygous for genetic mutations. Through genome editing, the clinical application of patient-specific genetic mutation-free iPS cells to genetic disorders can finally be realized.

语种: 英语
项目资助者: Takeda Science Foundation JAPAN ; Whitaker Foundation USA
WOS记录号: WOS:000304391000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55237
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: 1.Kyoto Univ, Inst Frontier Med Sci, Sakyo Ku, Kyoto 6068507, Japan
2.Peking Univ, Hosp 3, Dept Nephrol, Beijing 100191, Peoples R China

Recommended Citation:
Cheng, Li-Tao,Sun, Liang-Tso,Tada, Takashi. Genome editing in induced pluripotent stem cells[J]. GENES TO CELLS,2012,17(6):431-438.
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