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学科主题: 临床医学
题名:
Clinical application of radioimmunoimaging with Tc-99m-BDI-1 in the diagnosis of bladder cancer
作者: Wang, RF; Zhang, CL; Yu, LZ; Guo, YF
关键词: radioimmunoimaging ; bladder neoplasms ; antibody, monoclonal
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2000-05-01
卷: 113, 期:5, 页:396-399
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MONOCLONAL-ANTIBODY ; CARCINOMA
英文摘要:

Objective To evaluate the clinical application of radioimmunoimaging (RII) with (TC)-T-99m-BDI-1 in the diagnosis of bladder cancer.

Methods 32 patients with bladder cancer and 5 with normal bladder were studied. RII was performed 1 hour after intravesical administration of 111 - 222 MBq Tc-99m-BDI-1 followed by washing out and perfusing bladder with 50 mi PBS. The radioactivity ratio of target over background (C-T/C-B) was calculated.

Results The radiochemical purity of 99mTC-BDI-1 was greater than 95%. RII showed radioactive accumulation area for most of bladder cancers but no radio-active concentration for normal bladder. The sensitivity and specificity were 91.7% and 81.8% respectively with the assignment of the positive criterion of C-T/C(B)greater than or equal to 1.40. There was no statistical difference in sensitivity between tumors with diameters greater than or equal to 1 cm (1.0 -4.2 cm) and < 1 cm (0.2 - 0.8 cm). C-T/C-B was related to the pathological grade (G(1) - G(3)) of the tumor.

Conclusions RII by intravesical administration provides a new noninvasive method for the diagnosis of bladder cancer in morphology and in nature of tumor with high sensitivity and specificity. It may be used for the early diagnosis of bladder cancer, follow-up after surgery, and diagnosis of in situ tumor.

语种: 英语
WOS记录号: WOS:000087103600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55238
Appears in Collections:北京大学第一临床医学院_核医学科_期刊论文

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作者单位: 1.Beijing Med Univ, Hosp 1, Dept Nucl Med, Beijing 100034, Peoples R China
2.Beijing Med Univ, Hosp 1, Inst Urol, Beijing 100034, Peoples R China

Recommended Citation:
Wang, RF,Zhang, CL,Yu, LZ,et al. Clinical application of radioimmunoimaging with Tc-99m-BDI-1 in the diagnosis of bladder cancer[J]. CHINESE MEDICAL JOURNAL,2000,113(5):396-399.
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