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学科主题: 临床医学
题名:
LAPTM4B-35, a Cancer-Related Gene, Is Associated with Poor Prognosis in TNM Stages I-III Gastric Cancer Patients
作者: Cheng, Xiaojing1; Zheng, Zhixue2; Bu, Zhaode2; Wu, Xiaojiang2; Zhang, Lianhai2; Xing, Xiaofang1; Wang, Xiaohong3; Hu, Ying3; Du, Hong1; Li, Lin1; Li, Shen1; Zhou, Rouli4; Wen, Xian-Zi1; Ji, Jia-Fu2
刊名: PLOS ONE
发表日期: 2015-04-07
DOI: 10.1371/journal.pone.0121559
卷: 10, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; TETRATRANSMEMBRANE PROTEIN ; GALLBLADDER CARCINOMA ; OVEREXPRESSION ; EXPRESSION ; MARKER ; CELLS ; ADENOCARCINOMA ; PROGRESSION ; RESISTANCE
英文摘要:

Background

Lysosome-associated transmembrane protein 4 beta-35 (LAPTM4B-35), a member of the mammalian 4-tetratransmembrane spanning protein superfamily, has been reported to be overexpressed in several cancers. However the expression of LAPTM4B-35 and its role in the progression of gastric cancer (GC) remains unknown. The aim of this study was to investigate LAPTM4B-35 expression in GC, its potential relevance to clinicopathologic parameters and role of LAPTM4B-35 during gastric carcinogenesis.

Methods

In the present study, paraffin-embedded specimens with GC (n = 240, including 180 paired specimens) and 24 paired fresh frozen tissues were analyzed. qRT-PCR and immunohistochemistry (IHC) were used to analyze the expression of LAPTM4B-35 in GC. The effects of LAPTM4B-35 on GC cell proliferation, migration and invasion were determined by overexpression and knockdown assays.

Results

IHC showed that LAPTM4B-35 was expressed in 68.3% (123/180) of GC tissues, while in 16.1% (29/180) of their paired adjacent noncancerous gastric tissues (P = 0.000). LAPTM4B-35 mRNA levels in GC tissues were also significantly elevated when compared with their paired adjacent noncancerous tissues (P = 0.017). Overexpression of LAPTM4B-35 was significantly associated with degree of differentiation, depth of invasion, lymphovascular invasion and lymph node metastasis (P<0.05). Kaplan-Meier survival curves revealed that patients with LAPTM4B-35 expression had a significant decrease in overall survival (OS) in stages I-III GC patients (P = 0.006). Multivariate analysis showed high expression of LAPTM4B-35 was an independent prognostic factor for OS in stage I-III GC patients (P = 0.025).

Conclusion

These findings indicate that LAPTM4B-35 overexpression may be related to GC progression and poor prognosis, and thus may serve as a new prediction marker of prognosis in GC patients.

语种: 英语
所属项目编号: 30471677 ; 81141024 ; Z121100007512010
项目资助者: National Natural Science Foundation of China ; National Key Technology R&amp ; D Program (Beijing Municipal Science and Technology Project)
WOS记录号: WOS:000352477800065
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55242
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Gastrointestinal Carcinoma Translat Res Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Biol Tissue Bank, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
4.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Cheng, Xiaojing,Zheng, Zhixue,Bu, Zhaode,et al. LAPTM4B-35, a Cancer-Related Gene, Is Associated with Poor Prognosis in TNM Stages I-III Gastric Cancer Patients[J]. PLOS ONE,2015,10(4).
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