北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
LAPTM4B-35, a Cancer-Related Gene, Is Associated with Poor Prognosis in TNM Stages I-III Gastric Cancer Patients
作者: Cheng, Xiaojing1; Zheng, Zhixue2; Bu, Zhaode2; Wu, Xiaojiang2; Zhang, Lianhai2; Xing, Xiaofang1; Wang, Xiaohong3; Hu, Ying3; Du, Hong1; Li, Lin1; Li, Shen1; Zhou, Rouli4; Wen, Xian-Zi1; Ji, Jia-Fu2
刊名: PLOS ONE
发表日期: 2015-04-07
DOI: 10.1371/journal.pone.0121559
卷: 10, 期:4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; TETRATRANSMEMBRANE PROTEIN ; GALLBLADDER CARCINOMA ; OVEREXPRESSION ; EXPRESSION ; MARKER ; CELLS ; ADENOCARCINOMA ; PROGRESSION ; RESISTANCE
英文摘要:

Background

Lysosome-associated transmembrane protein 4 beta-35 (LAPTM4B-35), a member of the mammalian 4-tetratransmembrane spanning protein superfamily, has been reported to be overexpressed in several cancers. However the expression of LAPTM4B-35 and its role in the progression of gastric cancer (GC) remains unknown. The aim of this study was to investigate LAPTM4B-35 expression in GC, its potential relevance to clinicopathologic parameters and role of LAPTM4B-35 during gastric carcinogenesis.

Methods

In the present study, paraffin-embedded specimens with GC (n = 240, including 180 paired specimens) and 24 paired fresh frozen tissues were analyzed. qRT-PCR and immunohistochemistry (IHC) were used to analyze the expression of LAPTM4B-35 in GC. The effects of LAPTM4B-35 on GC cell proliferation, migration and invasion were determined by overexpression and knockdown assays.

Results

IHC showed that LAPTM4B-35 was expressed in 68.3% (123/180) of GC tissues, while in 16.1% (29/180) of their paired adjacent noncancerous gastric tissues (P = 0.000). LAPTM4B-35 mRNA levels in GC tissues were also significantly elevated when compared with their paired adjacent noncancerous tissues (P = 0.017). Overexpression of LAPTM4B-35 was significantly associated with degree of differentiation, depth of invasion, lymphovascular invasion and lymph node metastasis (P<0.05). Kaplan-Meier survival curves revealed that patients with LAPTM4B-35 expression had a significant decrease in overall survival (OS) in stages I-III GC patients (P = 0.006). Multivariate analysis showed high expression of LAPTM4B-35 was an independent prognostic factor for OS in stage I-III GC patients (P = 0.025).

Conclusion

These findings indicate that LAPTM4B-35 overexpression may be related to GC progression and poor prognosis, and thus may serve as a new prediction marker of prognosis in GC patients.

语种: 英语
所属项目编号: 30471677 ; 81141024 ; Z121100007512010
项目资助者: National Natural Science Foundation of China ; National Key Technology R&amp ; D Program (Beijing Municipal Science and Technology Project)
WOS记录号: WOS:000352477800065
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55242
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Canc Hosp & Inst, Gastrointestinal Carcinoma Translat Res Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Surg, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
3.Peking Univ, Canc Hosp & Inst, Biol Tissue Bank, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
4.Peking Univ, Dept Cell Biol, Sch Basic Med Sci, Beijing 100871, Peoples R China

Recommended Citation:
Cheng, Xiaojing,Zheng, Zhixue,Bu, Zhaode,et al. LAPTM4B-35, a Cancer-Related Gene, Is Associated with Poor Prognosis in TNM Stages I-III Gastric Cancer Patients[J]. PLOS ONE,2015,10(4).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Cheng, Xiaojing]'s Articles
[Zheng, Zhixue]'s Articles
[Bu, Zhaode]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Cheng, Xiaojing]‘s Articles
[Zheng, Zhixue]‘s Articles
[Bu, Zhaode]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace