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Branched-chain amino acids alleviate nonalcoholic steatohepatitis in rats
Li, Tianrun1; Geng, Leiluo2; Chen, Xin3; Miskowiec, Miranda2; Li, Xuan1; Dong, Bing2
关键词Branched-chain Amino Acids Fat Deposition Nonalcoholic Steatohepatitis Hepatic Blood Flow Steatosis Sd Rats
刊名APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME
2013-08-01
DOI10.1139/apnm-2012-0496
38期:8页:836-843
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics ; Physiology ; Sport Sciences
资助者Fundamental Research Funds for the Central Universities ; Scientific and Technical Supporting Programs ; Fundamental Research Funds for the Central Universities ; Scientific and Technical Supporting Programs
研究领域[WOS]Nutrition & Dietetics ; Physiology ; Sport Sciences
关键词[WOS]FATTY LIVER-DISEASE ; DIET-INDUCED OBESITY ; PORTAL-HYPERTENSION ; GENERAL-POPULATION ; RISK-FACTORS ; PREVALENCE ; MICE ; METABOLISM ; INSULIN ; SUPPLEMENTATION
英文摘要

Nonalcoholic steatohepatitis (NASH) is a prevalent disease in countries around the world. The branched-chain amino acids (BCAAs) leucine, isoleucine, and valine cannot be synthesized by the body and have been shown to promote muscle buildup; thus, it is logical to suggest that BCAAs can reduce fat deposition in the body. We used gonadectomized rats fed a high-fat diet to investigate the effects of BCAAs on lipid metabolism over an 8-week experimental period. Body composition, tissue histology, plasma lipid indices, and hormone levels were examined. We demonstrated that the body weights of rats were not significantly decreased but the mesenteric fat was significantly decreased (p < 0.05) in BCAA-treated rats. In addition, BCAAs decreased plasma lipid levels and fat deposition in the liver. At week 4, when the untreated rats displayed macrovesicular steatosis, BCAA-treated rats had only macrovesicular droplets in their hepatocytes. At week 8, when the untreated rat livers displayed profound inflammation and cirrhosis, BCAA-treated rat livers remained in the macrovesicular stage of steatosis. BCAAs induced higher blood glucose and plasma insulin levels (p < 0.05). BCAAs also improved liver blood flow by increasing mean arterial blood pressure and decreasing portal pressure, which helped delay the change in blood flow pattern to that of cirrhosis. BCAAs also induced the skeletal muscle to express higher levels of branched-chain alpha-keto acid dehydrogenase E1 alpha, which indicates an enhanced metabolic capacity of BCAAs in muscle tissue. This study clearly demonstrates the effects of BCAAs on the amelioration of fat deposition in rats fed a high-fat diet.

语种英语
所属项目编号212QJ097 ; 2012BAD51G01
资助者Fundamental Research Funds for the Central Universities ; Scientific and Technical Supporting Programs ; Fundamental Research Funds for the Central Universities ; Scientific and Technical Supporting Programs
WOS记录号WOS:000321892900005
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55244
专题北京大学第三临床医学院
作者单位1.309th Hosp, Dept Cadre Ward, Beijing 100193, Peoples R China
2.Peking Univ, Hosp 3, Dept Intervent & Vasc Surg, Beijing 100083, Peoples R China
3.China Agr Univ, State Key Lab Anim Nutr, Beijing 100193, Peoples R China
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GB/T 7714
Li, Tianrun,Geng, Leiluo,Chen, Xin,et al. Branched-chain amino acids alleviate nonalcoholic steatohepatitis in rats[J]. APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME,2013,38(8):836-843.
APA Li, Tianrun,Geng, Leiluo,Chen, Xin,Miskowiec, Miranda,Li, Xuan,&Dong, Bing.(2013).Branched-chain amino acids alleviate nonalcoholic steatohepatitis in rats.APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME,38(8),836-843.
MLA Li, Tianrun,et al."Branched-chain amino acids alleviate nonalcoholic steatohepatitis in rats".APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME 38.8(2013):836-843.
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