IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Effects of preeclampsia-like symptoms at early gestational stage on feto-placental outcomes in a mouse model
Ma Rui-qiong; Sun Min-na; Yang Zi
关键词Early Onset Preeclampsia Mouse Model Placenta
刊名CHINESE MEDICAL JOURNAL
2010-03-20
DOI10.3760/cma.j.issn.0366-6999.2010.06.013
123期:6页:707-712
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]General & Internal Medicine
关键词[WOS]PREGNANCY-INDUCED HYPERTENSION ; FETAL-GROWTH RESTRICTION ; ONSET PREECLAMPSIA ; HISTORY
英文摘要

Background Early and late-onset preeclampsia is thought to be different disease entities. This study aimed to determine the effects of early-onset preeclampsia-like symptoms on feto-placental outcomes and the adverse impacts of various factors on placental and fetal growth and development at different gestational stages in a mouse model.

Methods Pregnant C57BL/6J mice were divided into control and preeclampsia (PE) groups, and injected subcutaneously with the nitric oxide synthase inhibitor L-arginine methyl ester (L-NAME) 50 mg.kg(-1).d(-1). The PE group was divided into early-, mid- and late-PE groups with L-NAME injections starting on days 7, 11 and 16 of pregnancy, respectively. Corresponding control groups were injected with saline at the same time points. Blood pressure was measured until days 14 and 18, when the fetuses and placentas were removed under anesthesia. Blood pressure, urinary protein, and fetal and placental conditions were analyzed.

Results Blood pressure and urinary protein increased following L-NAME injection. The fetal survival rate and fetal weight were reduced and the fetal absorption rate was increased in the early-PE group on days 14 and 18 of pregnancy, compared with the control group. There were no significant differences in these parameters between the late-PE group and the respective control group. Placental weights in the early- and mid-PE groups were significantly reduced at days 14 and 18 of pregnancy compared with the control groups, but there was no significant difference in placental weight between the late-PE group and the respective control group. Morphologic examination of placentas from the early- and mid-PE groups showed varying degrees of fibrinoid necrosis and villous interstitial edema, but no significant pathologic changes were found in the placentas from the late-PE or control groups.

Conclusion Preeclampsia-like symptoms occurring during the early stage of pregnancy are more likely to affect placental and fetal development, whereas late onset preeclampsia-like symptoms have a direct impact on the mothers. Chin Med J 2010;123(6):707-712

语种英语
所属项目编号30840088
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000276230600013
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55245
专题北京大学第三临床医学院
作者单位Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ma Rui-qiong,Sun Min-na,Yang Zi. Effects of preeclampsia-like symptoms at early gestational stage on feto-placental outcomes in a mouse model[J]. CHINESE MEDICAL JOURNAL,2010,123(6):707-712.
APA Ma Rui-qiong,Sun Min-na,&Yang Zi.(2010).Effects of preeclampsia-like symptoms at early gestational stage on feto-placental outcomes in a mouse model.CHINESE MEDICAL JOURNAL,123(6),707-712.
MLA Ma Rui-qiong,et al."Effects of preeclampsia-like symptoms at early gestational stage on feto-placental outcomes in a mouse model".CHINESE MEDICAL JOURNAL 123.6(2010):707-712.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ma Rui-qiong]的文章
[Sun Min-na]的文章
[Yang Zi]的文章
百度学术
百度学术中相似的文章
[Ma Rui-qiong]的文章
[Sun Min-na]的文章
[Yang Zi]的文章
必应学术
必应学术中相似的文章
[Ma Rui-qiong]的文章
[Sun Min-na]的文章
[Yang Zi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。