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Altered collagen II 263-272 peptide immunization induces inhibition of collagen-induced arthritis through a shift toward Th2-type response
Li, R.1; Li, X.2; Li, Z.1
关键词Altered Peptide Ligands Collagen-induced Arthritis Th2-type Response Collagen Ii
刊名TISSUE ANTIGENS
2009-04-01
DOI10.1111/j.1399-0039.2009.01223.x
73期:4页:341-347
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology ; Pathology
研究领域[WOS]Cell Biology ; Immunology ; Pathology
关键词[WOS]T-CELL-ACTIVATION ; RHEUMATOID-ARTHRITIS ; RECEPTOR ANTAGONIST ; TRANSGENIC MICE ; ENCEPHALOMYELITIS ; SUPPRESSION ; RAT ; SEVERITY ; HLA-DRB1 ; LIGANDS
英文摘要

To investigate the effects of altered collagen II (CII) peptide ligands in collagen-induced arthritis (CIA), CIA rats were subcutaneously injected with an altered CII263-272 peptide ligand (APL, 100, 10, and 1 mu g/dose, six dose each, twice a week), which had been identified by us as an inhibitory effect on CII-specific T-cell activation in vitro in rheumatoid arthritis (RA). Clinical, radiographic, and histologic scores were evaluated. Serum level of interferon (IFN)-gamma was assessed by enzyme-linked immunosorbent assay, and the numbers of interleukin (IL)-4-producing cells in vitro in memory responses to the APL were determined by enzyme-linked immunospot. The results showed significantly reduced arthritis scores in CIA rats treated with 100 mu g/dose of APL compared with those treated with phosphate buffered solution (PBS) and control peptide. The mean radiographic and histologic scores were also markedly lower in APL-treated CIA rats. On day 35 after immunization, a significantly lower level of IFN-gamma in serum was found in APL-treated rats, accompanied by increased numbers of IL-4-producing cells, indicating that APL treatment skewed the T helper (Th)1/Th2 balance toward Th2-type response in vivo. Altered CII263-272 peptide ligand immunization induces inhibition of CIA through a shift toward Th2-type response, suggesting that altered CII peptide might be a potential therapeutic target for RA.

语种英语
WOS记录号WOS:000264188200008
项目编号30671933 ; 2007J23JH027
资助机构National Science Foundation of China ; Dalian Science and Technology Foundation
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55246
专题北京大学第二临床医学院
作者单位1.Dalian Univ, Dept Immunol, Sch Med, Dalian, Peoples R China
2.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Li, R.,Li, X.,Li, Z.. Altered collagen II 263-272 peptide immunization induces inhibition of collagen-induced arthritis through a shift toward Th2-type response[J]. TISSUE ANTIGENS,2009,73(4):341-347.
APA Li, R.,Li, X.,&Li, Z..(2009).Altered collagen II 263-272 peptide immunization induces inhibition of collagen-induced arthritis through a shift toward Th2-type response.TISSUE ANTIGENS,73(4),341-347.
MLA Li, R.,et al."Altered collagen II 263-272 peptide immunization induces inhibition of collagen-induced arthritis through a shift toward Th2-type response".TISSUE ANTIGENS 73.4(2009):341-347.
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