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学科主题: 临床医学
题名:
Altered collagen II 263-272 peptide immunization induces inhibition of collagen-induced arthritis through a shift toward Th2-type response
作者: Li, R.1; Li, X.2; Li, Z.1
关键词: altered peptide ligands ; collagen-induced arthritis ; Th2-type response ; collagen II
刊名: TISSUE ANTIGENS
发表日期: 2009-04-01
DOI: 10.1111/j.1399-0039.2009.01223.x
卷: 73, 期:4, 页:341-347
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology ; Pathology
研究领域[WOS]: Cell Biology ; Immunology ; Pathology
关键词[WOS]: T-CELL-ACTIVATION ; RHEUMATOID-ARTHRITIS ; RECEPTOR ANTAGONIST ; TRANSGENIC MICE ; ENCEPHALOMYELITIS ; SUPPRESSION ; RAT ; SEVERITY ; HLA-DRB1 ; LIGANDS
英文摘要:

To investigate the effects of altered collagen II (CII) peptide ligands in collagen-induced arthritis (CIA), CIA rats were subcutaneously injected with an altered CII263-272 peptide ligand (APL, 100, 10, and 1 mu g/dose, six dose each, twice a week), which had been identified by us as an inhibitory effect on CII-specific T-cell activation in vitro in rheumatoid arthritis (RA). Clinical, radiographic, and histologic scores were evaluated. Serum level of interferon (IFN)-gamma was assessed by enzyme-linked immunosorbent assay, and the numbers of interleukin (IL)-4-producing cells in vitro in memory responses to the APL were determined by enzyme-linked immunospot. The results showed significantly reduced arthritis scores in CIA rats treated with 100 mu g/dose of APL compared with those treated with phosphate buffered solution (PBS) and control peptide. The mean radiographic and histologic scores were also markedly lower in APL-treated CIA rats. On day 35 after immunization, a significantly lower level of IFN-gamma in serum was found in APL-treated rats, accompanied by increased numbers of IL-4-producing cells, indicating that APL treatment skewed the T helper (Th)1/Th2 balance toward Th2-type response in vivo. Altered CII263-272 peptide ligand immunization induces inhibition of CIA through a shift toward Th2-type response, suggesting that altered CII peptide might be a potential therapeutic target for RA.

语种: 英语
所属项目编号: 30671933 ; 2007J23JH027
项目资助者: National Science Foundation of China ; Dalian Science and Technology Foundation
WOS记录号: WOS:000264188200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55246
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Dalian Univ, Dept Immunol, Sch Med, Dalian, Peoples R China
2.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Li, R.,Li, X.,Li, Z.. Altered collagen II 263-272 peptide immunization induces inhibition of collagen-induced arthritis through a shift toward Th2-type response[J]. TISSUE ANTIGENS,2009,73(4):341-347.
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