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学科主题基础医学
Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy
Cui, Xin2,3; Wang, Yuhui2,3; Meng, Lingjun4; Fei, Weihua1; Deng, Jingna3,5; Xu, Guoheng3,5; Peng, Xingui6; Ju, Shenghong6; Zhang, Ling2,3; Liu, George2,3; Zhao, Liping4; Yang, Hongyuan1
关键词Berardinelli-seip Congenital Lipodystrophy Type 2 Fatty Liver
刊名AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
2012-03-01
DOI10.1152/ajpendo.00237.2011
302期:6页:E705-E713
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism ; Physiology
研究领域[WOS]Endocrinology & Metabolism ; Physiology
关键词[WOS]SEIP CONGENITAL LIPODYSTROPHY ; GENERALIZED LIPODYSTROPHY ; PROTEIN ; FAT ; DIFFERENTIATION ; DEFICIENCY ; MUTATIONS ; YEAST
英文摘要

Cui X, Wang Y, Meng L, Fei W, Deng J, Xu G, Peng X, Ju S, Zhang L, Liu G, Zhao L, Yang H. Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy. Am J Physiol Endocrinol Metab 302: E705-E713, 2012. First published January 10, 2012; doi:10.1152/ajpendo.00237.2011.-Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is a recessive disorder characterized by an almost complete loss of adipose tissue, insulin resistance, and fatty liver. BSCL2 is caused by loss-of-function mutations in the BSCL2/seipin gene, which encodes seipin. The essential role for seipin in adipogenesis has recently been established both in vitro and in vivo. However, seipin is highly upregulated at later stages of adipocyte development, and its role in mature adipocytes remains to be elucidated. We therefore generated transgenic mice overexpressing a short isoform of human BSCL2 gene (encoding 398 amino acids) using the adipocyte-specific aP2 promoter. The transgenic mice produced similar to 150% more seipin than littermate controls in white adipose tissue. Surprisingly, the increased expression of seipin markedly reduced the mass of white adipose tissue and the size of adipocytes and lipid droplets. This may be due in part to elevated lipolysis rates in the transgenic mice. Moreover, there was a nearly 50% increase in the triacylglycerol content of transgenic liver. These results suggest that seipin promotes the differentiation of preadipocytes but may inhibit lipid storage in mature adipocytes.

语种英语
WOS记录号WOS:000301791300009
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被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55251
专题北京大学基础医学院_心血管所
北京大学基础医学院
北京大学第二临床医学院_血液科
作者单位1.Natl Inst Biol Sci, Transgen Anim Ctr, Beijing, Peoples R China
2.Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Inst Cardiovasc Sci, Beijing 100871, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100871, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Minist Educ, Dept Physiol, Beijing 100871, Peoples R China
6.Southeast Univ, Dept Radiol, Zhong Da Hosp, Jiangsu Key Lab Mol Imaging & Funct Imaging, Nanjing, Peoples R China
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Cui, Xin,Wang, Yuhui,Meng, Lingjun,et al. Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2012,302(6):E705-E713.
APA Cui, Xin.,Wang, Yuhui.,Meng, Lingjun.,Fei, Weihua.,Deng, Jingna.,...&Yang, Hongyuan.(2012).Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy.AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,302(6),E705-E713.
MLA Cui, Xin,et al."Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy".AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 302.6(2012):E705-E713.
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