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学科主题: 基础医学
题名:
Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy
作者: Cui, Xin2,3; Wang, Yuhui2,3; Meng, Lingjun4; Fei, Weihua1; Deng, Jingna3,5; Xu, Guoheng3,5; Peng, Xingui6; Ju, Shenghong6; Zhang, Ling2,3; Liu, George2,3; Zhao, Liping4; Yang, Hongyuan1
关键词: Berardinelli-Seip congenital lipodystrophy type 2 ; fatty liver
刊名: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
发表日期: 2012-03-01
DOI: 10.1152/ajpendo.00237.2011
卷: 302, 期:6, 页:E705-E713
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Physiology
研究领域[WOS]: Endocrinology & Metabolism ; Physiology
关键词[WOS]: SEIP CONGENITAL LIPODYSTROPHY ; GENERALIZED LIPODYSTROPHY ; PROTEIN ; FAT ; DIFFERENTIATION ; DEFICIENCY ; MUTATIONS ; YEAST
英文摘要:

Cui X, Wang Y, Meng L, Fei W, Deng J, Xu G, Peng X, Ju S, Zhang L, Liu G, Zhao L, Yang H. Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy. Am J Physiol Endocrinol Metab 302: E705-E713, 2012. First published January 10, 2012; doi:10.1152/ajpendo.00237.2011.-Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2) is a recessive disorder characterized by an almost complete loss of adipose tissue, insulin resistance, and fatty liver. BSCL2 is caused by loss-of-function mutations in the BSCL2/seipin gene, which encodes seipin. The essential role for seipin in adipogenesis has recently been established both in vitro and in vivo. However, seipin is highly upregulated at later stages of adipocyte development, and its role in mature adipocytes remains to be elucidated. We therefore generated transgenic mice overexpressing a short isoform of human BSCL2 gene (encoding 398 amino acids) using the adipocyte-specific aP2 promoter. The transgenic mice produced similar to 150% more seipin than littermate controls in white adipose tissue. Surprisingly, the increased expression of seipin markedly reduced the mass of white adipose tissue and the size of adipocytes and lipid droplets. This may be due in part to elevated lipolysis rates in the transgenic mice. Moreover, there was a nearly 50% increase in the triacylglycerol content of transgenic liver. These results suggest that seipin promotes the differentiation of preadipocytes but may inhibit lipid storage in mature adipocytes.

语种: 英语
所属项目编号: 30821001 ; 30930037 ; 30971102 ; G2006CD503801 ; 568725
项目资助者: National Natural Science Foundation of the People&prime ; s Republic of China ; Major National Basic Research Program of the People&prime ; s Republic of China ; National Health and Medical Research Council of Australia
WOS记录号: WOS:000301791300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55251
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Natl Inst Biol Sci, Transgen Anim Ctr, Beijing, Peoples R China
2.Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW 2052, Australia
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Inst Cardiovasc Sci, Beijing 100871, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100871, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Minist Educ, Dept Physiol, Beijing 100871, Peoples R China
6.Southeast Univ, Dept Radiol, Zhong Da Hosp, Jiangsu Key Lab Mol Imaging & Funct Imaging, Nanjing, Peoples R China

Recommended Citation:
Cui, Xin,Wang, Yuhui,Meng, Lingjun,et al. Overexpression of a short human seipin/BSCL2 isoform in mouse adipose tissue results in mild lipodystrophy[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2012,302(6):E705-E713.
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