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学科主题: 临床医学
题名:
microRNA and inflammatory gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma
作者: Zhao, Yiqiang1; Schetter, Aaron J.1; Yang, Geoffrey B.1,2; Giang Nguyen1,2; Mathe, Ewy A.1; Li, Peng3,4; Cai, Hong5; Yu, Lei1,6; Liu, Fangfang5; Hang, Dong5; Yang, Haijun; Wang, Xin Wei1; Ke, Yang5; Harris, Curtis C.1
关键词: esophageal squamous cell carcinoma ; microRNA ; prognostic classifier ; inflammations
刊名: INTERNATIONAL JOURNAL OF CANCER
发表日期: 2013-06-15
DOI: 10.1002/ijc.27954
卷: 132, 期:12, 页:2901-2909
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; LYMPH-NODE METASTASIS ; TUMOR-SUPPRESSOR GENE ; LUNG-CANCER ; CLINICAL-SIGNIFICANCE ; COLORECTAL-CANCER ; POOR-PROGNOSIS ; RISK-FACTORS ; ADENOCARCINOMA ; ANGIOGENESIS
英文摘要:

MicroRNAs (miRNAs) and inflammatory genes have a role in the initiation and development of esophageal squamous cell carcinoma (ESCC). In our study, we examined the potential of using miRNA and inflammatory gene expression patterns as prognostic classifiers for ESCC. Five miRNAs and 25 inflammatory-related genes were measured by quantitative reverse transcriptase PCR in tumor tissues and adjacent noncancerous tissues from 178 Chinese patients with ESCC. The expression levels of miR-21 (p = 0.027), miR-181b (p = 0.002) and miR-146b (p = 0.021) in tumor tissue and miR-21 (p = 0.003) in noncancerous tissue were associated with overall survival of patients. These data were combined to generate a miRNA risk score that was significantly associated with worse prognosis (p = 0.0001), suggesting that these miRNAs may be useful prognostic classifiers for ESCC. To construct an inflammatory gene prognostic classifier, we divided the population into training (n = 124) and test cohorts (n = 54). The expression levels of CRY61, CTGF and IL-18 in tumor tissue and VEGF in adjacent noncancerous tissue were modestly associated with prognosis in the training cohort |Z-score| > 1.5 and were subsequently used to construct a Cox regression-based inflammatory risk score (IRS). IRS was significantly associated with survival in both the training cohort (p = 0.002) and the test cohort (p = 0.005). Furthermore, Cox regression models combining both miRNA risk score and IRS performed significantly better than models with either alone (p < 0.001 likelihood ratio test). Therefore, miRNA and inflammatory gene expression patterns, alone or in combination, have potential as prognostic classifiers for ESCC and may help to guide therapeutic decisions.

语种: 英语
所属项目编号: 30872937 ; 30930102 ; 2011CB504301 ; 7100001
项目资助者: National Cancer Institute, Center for Cancer Research at the National Institutes of Health ; Natural Science Foundation of China ; National Ministry of Science and Technology (973 Project) ; Natural Science Foundation of Beijing
WOS记录号: WOS:000317593100020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55254
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.NCI, Human Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA
2.Howard Hughes Med Inst, Chevy Chase, MD USA
3.NIH, Biostat Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
4.Capital Normal Univ, Sch Math Sci, Beijing, Peoples R China
5.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100871, Peoples R China
6.Fudan Univ, Zhongshan Hosp, Liver Canc Inst, Shanghai 200433, Peoples R China

Recommended Citation:
Zhao, Yiqiang,Schetter, Aaron J.,Yang, Geoffrey B.,et al. microRNA and inflammatory gene expression as prognostic marker for overall survival in esophageal squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF CANCER,2013,132(12):2901-2909.
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