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学科主题: 临床医学
题名:
Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction
作者: Shi, Bing1,2,3; Guo, Yanhong1,2; Wang, Juan1,4; Gao, Wei1,2
刊名: BMC CARDIOVASCULAR DISORDERS
发表日期: 2010-03-01
DOI: 10.1186/1471-2261-10-11
卷: 10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: DYSREGULATION ; REVEALS ; MODEL
英文摘要:

Background: MicroRNAs(miRNAs) are important cellular components and their dysfunction is associated with various diseases. Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Although several miRNAs are reported to be associated with AMI, more novel miRNAs are needed to further investigate and improve certainty

Methods: We applied a well-established acute myocardial infarction rat model and performed miRNAs microarray experiments upon the myocardium tissue of rats with AMI and under sham control. We identified the differentially expressed miRNAs and analyzed the function of miRNA targets, transcription factors, and host genes based on bioinformatics.

Results: As a result, the levels of expression of seventeen miRNAs significantly deregulated, of which four miRNAs were further validated by qRT-PCR. In addition, we observed that the transcription factors, targets, and host genes of these deregulated miRNAs are enriched in cardiovascular-related functions.

Conclusion: We found that the miRNAs expression level altered in rats with AMI and differentially expressed miRNAs may be novel biomarkers of AMI.

语种: 英语
所属项目编号: 2007CB512100
项目资助者: State Basic Research Development Program of People&prime ; s Republic of China
WOS记录号: WOS:000276332700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55256
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, MOE Key Lab Mol Cardiol, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100871, Peoples R China
3.Beijing Mil Gen Hosp, Dept Cardiol, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100871, Peoples R China

Recommended Citation:
Shi, Bing,Guo, Yanhong,Wang, Juan,et al. Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction[J]. BMC CARDIOVASCULAR DISORDERS,2010,10.
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