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学科主题临床医学
Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction
Shi, Bing1,2,3; Guo, Yanhong1,2; Wang, Juan1,4; Gao, Wei1,2
刊名BMC CARDIOVASCULAR DISORDERS
2010-03-01
DOI10.1186/1471-2261-10-11
10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]DYSREGULATION ; REVEALS ; MODEL
英文摘要

Background: MicroRNAs(miRNAs) are important cellular components and their dysfunction is associated with various diseases. Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Although several miRNAs are reported to be associated with AMI, more novel miRNAs are needed to further investigate and improve certainty

Methods: We applied a well-established acute myocardial infarction rat model and performed miRNAs microarray experiments upon the myocardium tissue of rats with AMI and under sham control. We identified the differentially expressed miRNAs and analyzed the function of miRNA targets, transcription factors, and host genes based on bioinformatics.

Results: As a result, the levels of expression of seventeen miRNAs significantly deregulated, of which four miRNAs were further validated by qRT-PCR. In addition, we observed that the transcription factors, targets, and host genes of these deregulated miRNAs are enriched in cardiovascular-related functions.

Conclusion: We found that the miRNAs expression level altered in rats with AMI and differentially expressed miRNAs may be novel biomarkers of AMI.

语种英语
WOS记录号WOS:000276332700001
项目编号2007CB512100
资助机构State Basic Research Development Program of People&prime ; s Republic of China
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被引频次:40[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55256
专题北京大学第三临床医学院_心血管内科
作者单位1.Peking Univ, MOE Key Lab Mol Cardiol, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100871, Peoples R China
3.Beijing Mil Gen Hosp, Dept Cardiol, Beijing, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Beijing 100871, Peoples R China
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GB/T 7714
Shi, Bing,Guo, Yanhong,Wang, Juan,et al. Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction[J]. BMC CARDIOVASCULAR DISORDERS,2010,10.
APA Shi, Bing,Guo, Yanhong,Wang, Juan,&Gao, Wei.(2010).Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction.BMC CARDIOVASCULAR DISORDERS,10.
MLA Shi, Bing,et al."Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction".BMC CARDIOVASCULAR DISORDERS 10(2010).
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