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学科主题临床医学
Urinary Uromodulin Excretion Predicts Progression of Chronic Kidney Disease Resulting from IgA Nephropathy
Zhou, Jingjing1; Chen, Yuqing1; Liu, Ying1; Shi, Sufang1; Wang, Suxia2; Li, Xueying3; Zhang, Hong1; Wang, Haiyan1
刊名PLOS ONE
2013-08-22
DOI10.1371/journal.pone.0071023
8期:8
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]TAMM-HORSFALL PROTEIN ; GLOMERULAR-FILTRATION-RATE ; OXFORD CLASSIFICATION ; GLYCOPROTEIN ; EXPRESSION ; PATHOGENESIS ; MUTATIONS ; EQUATION
英文摘要

Background: Uromodulin, or Tamm-Horsfall protein, is the most abundant urinary protein in healthy individuals. Recent studies have suggested that uromodulin may play a role in chronic kidney diseases. We examined an IgA nephropathy cohort to determine whether uromodulin plays a role in the progression of IgA nephropathy.

Methods: A total of 344 IgA nephropathy patients were involved in this study. Morphological changes were evaluated with the Oxford classification of IgA nephropathy. Enzyme Linked Immunosorbent Assay (ELISA) measured the urinary uromodulin level on the renal biopsy day. Follow up was done regularly on 185 patients. Time-average blood pressure, time-average proteinuria, estimated glomerular filtration rate (eGFR) and eGFR decline rate were caculated. Association between the urinary uromodulin level and the eGFR decline rate was analyzed with SPSS 13.0.

Results: We found that lower baseline urinary uromodulin levels (P = 0.03) and higher time-average proteinuria (P = 0.04) were risk factors for rapid eGFR decline in a follow-up subgroup of the IgA nephropathy cohort. Urinary uromodulin level was correlated with tubulointerstitial lesions (P = 0.016). Patients that had more tubular atrophy/interstitial fibrosis on the surface had lower urinary uromodulin levels (P = 0.02).

Conclusions: Urinary uromodulin level is associated with interstitial fibrosis/tubular atrophy and contributes to eGFR decline in IgA nephropathy.

语种英语
WOS记录号WOS:000324470700009
项目编号NCET-10-0186/BMU 20110156
资助机构Chinese 985 project from the government
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55259
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_电镜室
北京大学第一临床医学院_医学统计室
作者单位1.Peking Univ, Hosp 1, Dept Stat, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Lab Electron Microscopy, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Jingjing,Chen, Yuqing,Liu, Ying,et al. Urinary Uromodulin Excretion Predicts Progression of Chronic Kidney Disease Resulting from IgA Nephropathy[J]. PLOS ONE,2013,8(8).
APA Zhou, Jingjing.,Chen, Yuqing.,Liu, Ying.,Shi, Sufang.,Wang, Suxia.,...&Wang, Haiyan.(2013).Urinary Uromodulin Excretion Predicts Progression of Chronic Kidney Disease Resulting from IgA Nephropathy.PLOS ONE,8(8).
MLA Zhou, Jingjing,et al."Urinary Uromodulin Excretion Predicts Progression of Chronic Kidney Disease Resulting from IgA Nephropathy".PLOS ONE 8.8(2013).
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