IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats
Liang, Jing1,2,3; Ma, Si-Si1,2; Li, Yi-Jing1,2; Ping, Xing-Jie1,2; Hu, Ling1,2; Cui, Cai-Lian1,2
关键词Morphine Conditioned place preference (CPP) Dopamine (DA) Tyrosine hydroxylase (TH)
刊名NEUROCHEMICAL RESEARCH
2012-07-01
DOI10.1007/s11064-012-0739-8
37期:7页:1482-1489
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
资助者National Natural Science Foundation ; National Basic Research Program ; National Natural Science Foundation ; National Basic Research Program
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]GENE-EXPRESSION ; SHELL DOPAMINE ; DEFICIENT MICE ; REWARD ; PHOSPHORYLATION ; RECEPTORS ; SYSTEMS ; BRAIN ; RESPONSES ; RELEASE
英文摘要

Our previous study demonstrated that morphine dose- and time-dependently elevated dopamine (DA) concentrations in the nucleus accumbens (NAc) during the expression of morphine-induced conditioned place preference (CPP) in rats. However, still unknown are how DA concentrations dynamically change during the morphine-induced CPP test and whether tyrosine hydroxylase (TH) activity in the ventral tegmental area (VTA) plays a vital role in this process. In the present study, we measured dynamic changes in TH and phosphorylated TH serine 40 (pTH Ser(40)) and pTH Ser(31) proteins in the VTA, and DA concentrations in the NAc at 5 min intervals during a 30 min morphine-induced CPP test. Rats that underwent morphine-induced CPP training significantly preferred the morphine-paired chamber during the CPP expression test, an effect that lasted at least 30 min in the drug-free state. DA concentrations in the NAc markedly increased at 15 min when the rats were returned to the CPP boxes to assess the expression of preference for the previously drug-paired chamber. DA concentrations then declined 2 h after the CPP test. TH and pTH Ser(40) levels, but not pTH Ser(31) levels, in the VTA were enhanced during the CPP test. These results indicated that TH and the phosphorylation of TH Ser(40) in the VTA may be responsible for DA synthesis and release in the NAc during the behavioral expression of conditioned reward elicited by a drug-associated context.

语种英语
所属项目编号30970933 ; 2009CB522003
资助者National Natural Science Foundation ; National Basic Research Program ; National Natural Science Foundation ; National Basic Research Program
WOS记录号WOS:000304878200013
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55262
Collection北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100083, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Liang, Jing,Ma, Si-Si,Li, Yi-Jing,et al. Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats[J]. NEUROCHEMICAL RESEARCH,2012,37(7):1482-1489.
APA Liang, Jing,Ma, Si-Si,Li, Yi-Jing,Ping, Xing-Jie,Hu, Ling,&Cui, Cai-Lian.(2012).Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats.NEUROCHEMICAL RESEARCH,37(7),1482-1489.
MLA Liang, Jing,et al."Dynamic Changes of Tyrosine Hydroxylase and Dopamine Concentrations in the Ventral Tegmental Area-Nucleus Accumbens Projection During the Expression of Morphine-Induced Conditioned Place Preference in Rats".NEUROCHEMICAL RESEARCH 37.7(2012):1482-1489.
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