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学科主题: 药学
题名:
Synthesis and Analgesic Activity of Dispirocyclopiperazinium Analogues
作者: Wang Xin; Liu Wenjun; Li Gang; Ye Jia; Cheng Tieming; Li Runtao
关键词: piperazine ; spirocyclopiperazinium ; synthesize ; analgesic activity ; structure-activity relationship
刊名: CHINESE JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2010-10-01
卷: 30, 期:10, 页:1559-1562
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: UNIQUE SPIROCYCLOPIPERAZINIUM SALT ; BIOLOGICAL-ACTIVITIES ; EPIBATIDINE
英文摘要:

A series of dispirocyclopiperazinium analogues were synthesized by the reaction of hexanedioyl chloride, piperazine analogues and dibromides. The structures of target compounds were characterized by (1)H NMR, (13)C NMR spectra and elemental analysis. Preliminary bioassay test indicated that most of the compounds showed significant analgesic activity, and the structure-activity relationship was revealed.

语种: 中文
WOS记录号: WOS:000283962200020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55264
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wang Xin,Liu Wenjun,Li Gang,et al. Synthesis and Analgesic Activity of Dispirocyclopiperazinium Analogues[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2010,30(10):1559-1562.
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