|Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer|
|Wang, Shumin1,2; Dai, Zhifei3; Ke, Hengte4; Qu, Enze1; Qi, Xiaoxu5; Zhang, Kuo5; Wang, Jinrui1|
|关键词||Phototherapy Ultrasonography Breast Neoplasms Nanoparticles Laser Therapy Thermal Ablation Ultrasound Guidance|
|刊名||EUROPEAN JOURNAL OF RADIOLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Radiology, Nuclear Medicine & Medical Imaging|
|研究领域[WOS]||Radiology, Nuclear Medicine & Medical Imaging|
|关键词[WOS]||RADIOFREQUENCY ABLATION ; INITIAL-EXPERIENCE ; LASER THERAPY ; CARCINOMA ; TUMORS|
Objectives: The purpose of this study was to test whether dual functional gold nano-shelled microcapsules (GNS-MCs) can be used as an ultrasound imaging enhancer and as an optical absorber for photothermal therapy (PTT) in a rodent model of breast cancer.
Methods: GNS-MCs were fabricated with an inner air and outer gold nanoshell spherical structure. Photothermal cytotoxicity of GNS-MCs was tested with BT474 cancer cells in vitro and non-obese diabetes-SCID (NOD/SCID) mice with breast cancer. GNS-MCs were injected into the tumor under ultrasound guidance and treated with near-infrared (NIR) laser irradiation. The photothermal ablative effectiveness of GNS-MCs was evaluated by measuring the surface and internal temperature of the tumor as well as the size of the tumor using histological confirmation.
Results: NIR laser irradiation resulted in significant tumor cell death in GNS-MCs-treated BT474 cells in vitro. GNS-MCs were able to serve as an ultrasound enhancer to guide the intratumoral injection of GNS-MCs and ensure their uniform distribution. In vivo studies revealed that NIR laser irradiation increased the intratumoral temperature to nearly 70 C for 8 min in GNS-MCs-treated mice. Tumor volumes decreased gradually and tumors were completely ablated in 6 out of 7 mice treated with GNS-MCs and laser irradiation by 17 days after treatment.
Conclusion: This study demonstrates that ultrasound-guided PTT with theranostic GNS-MCs is a promising technique for in situ treatment of breast cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
|项目编号||NSFC-81171347 ; NSFC-81260221 ; 2010MS1155|
|资助机构||National Natural Science Foundation of China ; Inner Mongolia Natural Science Foundation|
|作者单位||1.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China|
2.Ordos Ctr Hosp, Ordos 017000, Inner Mongolia, Peoples R China
3.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
4.Harbin Inst Technol, Nanomed & Biosensor Lab, Sch Life Sci & Technol, Harbin 150001, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100019, Peoples R China
|Wang, Shumin,Dai, Zhifei,Ke, Hengte,et al. Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer[J]. EUROPEAN JOURNAL OF RADIOLOGY,2014,83(1):117-122.|
|APA||Wang, Shumin.,Dai, Zhifei.,Ke, Hengte.,Qu, Enze.,Qi, Xiaoxu.,...&Wang, Jinrui.(2014).Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer.EUROPEAN JOURNAL OF RADIOLOGY,83(1),117-122.|
|MLA||Wang, Shumin,et al."Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer".EUROPEAN JOURNAL OF RADIOLOGY 83.1(2014):117-122.|