IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科
学科主题临床医学
Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer
Wang, Shumin1,2; Dai, Zhifei3; Ke, Hengte4; Qu, Enze1; Qi, Xiaoxu5; Zhang, Kuo5; Wang, Jinrui1
关键词Phototherapy Ultrasonography Breast Neoplasms Nanoparticles Laser Therapy Thermal Ablation Ultrasound Guidance
刊名EUROPEAN JOURNAL OF RADIOLOGY
2014
DOI10.1016/j.ejrad.2013.09.010
83期:1页:117-122
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]RADIOFREQUENCY ABLATION ; INITIAL-EXPERIENCE ; LASER THERAPY ; CARCINOMA ; TUMORS
英文摘要

Objectives: The purpose of this study was to test whether dual functional gold nano-shelled microcapsules (GNS-MCs) can be used as an ultrasound imaging enhancer and as an optical absorber for photothermal therapy (PTT) in a rodent model of breast cancer.

Methods: GNS-MCs were fabricated with an inner air and outer gold nanoshell spherical structure. Photothermal cytotoxicity of GNS-MCs was tested with BT474 cancer cells in vitro and non-obese diabetes-SCID (NOD/SCID) mice with breast cancer. GNS-MCs were injected into the tumor under ultrasound guidance and treated with near-infrared (NIR) laser irradiation. The photothermal ablative effectiveness of GNS-MCs was evaluated by measuring the surface and internal temperature of the tumor as well as the size of the tumor using histological confirmation.

Results: NIR laser irradiation resulted in significant tumor cell death in GNS-MCs-treated BT474 cells in vitro. GNS-MCs were able to serve as an ultrasound enhancer to guide the intratumoral injection of GNS-MCs and ensure their uniform distribution. In vivo studies revealed that NIR laser irradiation increased the intratumoral temperature to nearly 70 C for 8 min in GNS-MCs-treated mice. Tumor volumes decreased gradually and tumors were completely ablated in 6 out of 7 mice treated with GNS-MCs and laser irradiation by 17 days after treatment.

Conclusion: This study demonstrates that ultrasound-guided PTT with theranostic GNS-MCs is a promising technique for in situ treatment of breast cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000329429900027
项目编号NSFC-81171347 ; NSFC-81260221 ; 2010MS1155
资助机构National Natural Science Foundation of China ; Inner Mongolia Natural Science Foundation
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55268
专题北京大学第三临床医学院_超声诊断科
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
2.Ordos Ctr Hosp, Ordos 017000, Inner Mongolia, Peoples R China
3.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
4.Harbin Inst Technol, Nanomed & Biosensor Lab, Sch Life Sci & Technol, Harbin 150001, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100019, Peoples R China
推荐引用方式
GB/T 7714
Wang, Shumin,Dai, Zhifei,Ke, Hengte,et al. Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer[J]. EUROPEAN JOURNAL OF RADIOLOGY,2014,83(1):117-122.
APA Wang, Shumin.,Dai, Zhifei.,Ke, Hengte.,Qu, Enze.,Qi, Xiaoxu.,...&Wang, Jinrui.(2014).Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer.EUROPEAN JOURNAL OF RADIOLOGY,83(1),117-122.
MLA Wang, Shumin,et al."Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer".EUROPEAN JOURNAL OF RADIOLOGY 83.1(2014):117-122.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Shumin]的文章
[Dai, Zhifei]的文章
[Ke, Hengte]的文章
百度学术
百度学术中相似的文章
[Wang, Shumin]的文章
[Dai, Zhifei]的文章
[Ke, Hengte]的文章
必应学术
必应学术中相似的文章
[Wang, Shumin]的文章
[Dai, Zhifei]的文章
[Ke, Hengte]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。