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IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科  > 期刊论文
学科主题: 临床医学
题名:
Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer
作者: Wang, Shumin1,2; Dai, Zhifei3; Ke, Hengte4; Qu, Enze1; Qi, Xiaoxu5; Zhang, Kuo5; Wang, Jinrui1
关键词: Phototherapy ; Ultrasonography ; Breast neoplasms ; Nanoparticles ; Laser therapy ; Thermal ablation ; Ultrasound guidance
刊名: EUROPEAN JOURNAL OF RADIOLOGY
发表日期: 2014
DOI: 10.1016/j.ejrad.2013.09.010
卷: 83, 期:1, 页:117-122
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: RADIOFREQUENCY ABLATION ; INITIAL-EXPERIENCE ; LASER THERAPY ; CARCINOMA ; TUMORS
英文摘要:

Objectives: The purpose of this study was to test whether dual functional gold nano-shelled microcapsules (GNS-MCs) can be used as an ultrasound imaging enhancer and as an optical absorber for photothermal therapy (PTT) in a rodent model of breast cancer.

Methods: GNS-MCs were fabricated with an inner air and outer gold nanoshell spherical structure. Photothermal cytotoxicity of GNS-MCs was tested with BT474 cancer cells in vitro and non-obese diabetes-SCID (NOD/SCID) mice with breast cancer. GNS-MCs were injected into the tumor under ultrasound guidance and treated with near-infrared (NIR) laser irradiation. The photothermal ablative effectiveness of GNS-MCs was evaluated by measuring the surface and internal temperature of the tumor as well as the size of the tumor using histological confirmation.

Results: NIR laser irradiation resulted in significant tumor cell death in GNS-MCs-treated BT474 cells in vitro. GNS-MCs were able to serve as an ultrasound enhancer to guide the intratumoral injection of GNS-MCs and ensure their uniform distribution. In vivo studies revealed that NIR laser irradiation increased the intratumoral temperature to nearly 70 C for 8 min in GNS-MCs-treated mice. Tumor volumes decreased gradually and tumors were completely ablated in 6 out of 7 mice treated with GNS-MCs and laser irradiation by 17 days after treatment.

Conclusion: This study demonstrates that ultrasound-guided PTT with theranostic GNS-MCs is a promising technique for in situ treatment of breast cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: NSFC-81171347 ; NSFC-81260221 ; 2010MS1155
项目资助者: National Natural Science Foundation of China ; Inner Mongolia Natural Science Foundation
WOS记录号: WOS:000329429900027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55268
Appears in Collections:北京大学第三临床医学院_超声诊断科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
2.Ordos Ctr Hosp, Ordos 017000, Inner Mongolia, Peoples R China
3.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
4.Harbin Inst Technol, Nanomed & Biosensor Lab, Sch Life Sci & Technol, Harbin 150001, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100019, Peoples R China

Recommended Citation:
Wang, Shumin,Dai, Zhifei,Ke, Hengte,et al. Contrast ultrasound-guided photothermal therapy using gold nanoshelled microcapsules in breast cancer[J]. EUROPEAN JOURNAL OF RADIOLOGY,2014,83(1):117-122.
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