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Association of chromosome 5q21.3 polymorphisms with the exploratory eye movement dysfunction in schizophrenia
Ma, Yuanlin1,2; Li, Jun1,2; Yu, Hao1,2,3,4; Wang, Lifang1,2; Lu, Tianlan1,2; Pan, Chao1,2; Han, Yonghua1,2; Zhang, Dai1,2,3,4,5; Yue, Weihua1,2
刊名SCIENTIFIC REPORTS
2015-08-05
DOI10.1038/srep10299
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Key Technology R&amp ; D Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; National Key Technology R&amp ; D Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GENOME-WIDE ASSOCIATION ; ALPHA-MANNOSIDASE-II ; ABNORMALITY ; TRAFFICKING ; GENETICS ; MARKER ; RISK
英文摘要

Schizophrenia patients show abnormalities in many eye movement tasks. Among them, exploratory eye movements (EEM) dysfunction seems to be specific to schizophrenia. However the mechanism of EEM disturbances in schizophrenia patients remains elusive. We investigate the relationship between EEM and single nucleotide polymorphisms (SNPs) or genes to identify susceptibility loci for EEM in schizophrenia. We firstly performed EEM test, then performed a genome-wide association study (GWAS) and gene-based association study of EEM in 128 individuals with schizophrenia and 143 healthy control subjects. Comparing to healthy controls, schizophrenia patients show significant decrease in NEF (22.99 +/- 3.96 vs. 26.02 +/- 5.72, P < 0.001), TESL (368.78 +/- 123.57 vs. 603.12 +/- 178.63, P < 0.001), MESL (16.86 +/- 5.27 vs. 24.42 +/- 6.46, P < 0.001), RSS (8.22 +/- 1.56 vs. 10.92 +/- 1.09, P < 0.001), and CSS (5.06 +/- 0.97 vs. 6.64 +/- 0.87, P < 0.001). Five SNPs of the MAN2A1, at 5q21.3, were associated with EEM abnormalities (deceased CSS) and satisfied the criteria of GWAS significance threshold. One is localized near 5′-UTR (rs17450784) and four are in intron (rs1438663, rs17162094, rs6877440 and rs10067856) of the gene. Our findings suggest that the identified loci may control the schizophrenia-related quantitative EEM trait. And the identified gene, associated with the EEM phenotype, may lead to new insights into the etiology of schizophrenia.

语种英语
所属项目编号2015BAI13B01 ; 81222017 ; 91232305 ; 81361120395 ; 91432304 ; NCET-12-0008
资助者National Key Technology R&amp ; D Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University ; National Key Technology R&amp ; D Program of China ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
WOS记录号WOS:000359136900001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55274
Collection北京大学精神卫生研究所
作者单位1.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
2.Peking Univ, Inst Mental Hlth, Hosp 6, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Tsinghua Univ, Peking Univ, Joint Ctr Life Sci, Beijing 100871, Peoples R China
5.Peking Univ, PKU IDG, McGovern Inst Brain Res, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Ma, Yuanlin,Li, Jun,Yu, Hao,et al. Association of chromosome 5q21.3 polymorphisms with the exploratory eye movement dysfunction in schizophrenia[J]. SCIENTIFIC REPORTS,2015,5.
APA Ma, Yuanlin.,Li, Jun.,Yu, Hao.,Wang, Lifang.,Lu, Tianlan.,...&Yue, Weihua.(2015).Association of chromosome 5q21.3 polymorphisms with the exploratory eye movement dysfunction in schizophrenia.SCIENTIFIC REPORTS,5.
MLA Ma, Yuanlin,et al."Association of chromosome 5q21.3 polymorphisms with the exploratory eye movement dysfunction in schizophrenia".SCIENTIFIC REPORTS 5(2015).
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