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学科主题: 药学
题名:
Efficient Preparation of Photolabile Agent MNI-glu by Regioselective Nitration of 4-Methoxyindoline Derivative
作者: Wang, Xiaowei1; Gao, Yu1; Xu, Yang1; Li, Li1; Zhang, Zhili1; Liu, Junyi1,2
关键词: Aromatic nitration ; caged L-glutamate ; claypop ; nitroindolines ; photorelease agent
刊名: SYNTHETIC COMMUNICATIONS
发表日期: 2009
DOI: 10.1080/00397910902883645
卷: 39, 期:22, 页:4030-4038
收录类别: SCI ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: L-GLUTAMATE ; 1-ACYL-7-NITROINDOLINES ; PHOTORELEASE ; PRECURSOR
英文摘要:

The present work investigates the nitration of 4-methoxy indoline derivative with different reagents and optimized conditions. We now report a simple methodology for nitration employing claycop in the presence of amine, which offers significant improvement with regard to the yield and regioselectivity, and a much more favorable isomeric ratio of products was obtained under mild conditions. Therefore, a useful method for preparation of a photolabile L-glutamate derivative was concurrently established.

语种: 英语
项目资助者: National Science Foundation of China ; Ministry of Education of China
WOS记录号: WOS:000272207000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55281
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Xiaowei,Gao, Yu,Xu, Yang,et al. Efficient Preparation of Photolabile Agent MNI-glu by Regioselective Nitration of 4-Methoxyindoline Derivative[J]. SYNTHETIC COMMUNICATIONS,2009,39(22):4030-4038.
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