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学科主题: 临床医学
题名:
Comparison of dexamethasone intravitreal implant and intravitreal triamcinolone acetonide for the treatment of pseudophakic cystoid macular edema in diabetic patients
作者: Dang, Yalong1; Mu, Yalin2; Li, Lin3; Mu, Yahui2; Liu, Shujing2; Zhang, Chun4; Zhu, Yu1; Xu, Yimin4
关键词: dexamethasone implant ; intravitreal triamcinolone acetonide ; pseudophakic cystoid macular edema ; diabetic retinopathy ; corticosteroid ; inflammation
刊名: DRUG DESIGN DEVELOPMENT AND THERAPY
发表日期: 2014
DOI: 10.2147/DDDT.S66611
卷: 8, 页:1441-1449
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: RETINAL VEIN OCCLUSION ; OPTICAL COHERENCE TOMOGRAPHY ; DRUG-DELIVERY SYSTEM ; VISUAL-ACUITY ; THICKNESS ; PHACOEMULSIFICATION ; COMBINATION ; BRANCH ; LASER
英文摘要:

Background and objective: Our objective was to investigate the efficacy and safety of dexamethasone (DEX) implant for the treatment of pseudophakic cystoid macular edema (PCME) in diabetic patients.

Study design: This was a prospective, non-randomized, interventional case series of 43 participants. Eighteen patients were enrolled in the DEX implant group and 25 were enrolled in an intravitreal triamcinolone acetonide (IVTA) group.

Main outcome measures: The primary efficacy measurement was the percentage of patients who gained improvements of more than ten letters in best corrected visual acuity (BCVA) during 6 months of follow-up. Other efficacy measurements included change in BCVA, change in central macular thickness (CMT), and number of retreatments. The primary safety evaluation was the percentage of patients with intraocular hypertension and variation in intraocular pressure (IOP) during 6 months of follow-up. Other adverse events, such as conjunctival hemorrhage, eye pain, secondary infection, endophthalmitis, noninfectious inflammation, retinal detachment, and implant migration, were also recorded during follow-up.

Results: At month 1, we observed that the percentage of patients gaining improvement of more than ten letters was similar in both groups (P=0.625). As patients in the IVTA group were retreated several times, this effect persisted throughout the study (P=0.941 at month 2, P=0.553 at month 3, P=0.856 at month 6). Variations in CMT were noticed at week 1 and reached their maximum at month 1. No significant difference was found between the two groups (P=0.831 at week 1, P=0.783 at month 1). At month 1, the variation in IOP reached its maximum in the DEX implant group and then decreased slightly. However, in the IVTA group, it increased continuously throughout the study. Conjunctival hemorrhage and eye pain were found in both groups, but both were rated as mild in severity, and no significant difference was found (P=0.184, P=0.766, respectively).

Conclusion: Both IVTA and DEX implants could effectively restore visual function and recover morphological change in diabetic patients with PCME for at least 6 months, but repeated intravitreal injection was required in the IVTA group. DEX implant is well tolerated. We suggest that intravitreal injection of DEX implant is a promising new therapeutic option for diabetic patients with PCME.

语种: 英语
所属项目编号: 2013GH11 ; 81371017 ; 13A320427
项目资助者: International Cooperation Project of Henan Province ; National Natural Science Foundation of China ; Key Project of Science Research of Henan Province Education Bureau
WOS记录号: WOS:000341756700001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55288
Appears in Collections:北京大学第三临床医学院_眼科_期刊论文

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作者单位: 1.Zhengzhou Univ, Affiliated Hosp 1, Dept Ophthalmol, Zhengzhou 450052, Henan Province, Peoples R China
2.Henan Univ Sci & Technol, Yellow River Hosp, Dept Ophthalmol, Sanmenxia, Henan Province, Peoples R China
3.Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Ophthalmol, Luoyang, Henan Province, Peoples R China
4.Peking Univ, Hosp 3, Dept Ophthalmol, Beijing 100871, Peoples R China

Recommended Citation:
Dang, Yalong,Mu, Yalin,Li, Lin,et al. Comparison of dexamethasone intravitreal implant and intravitreal triamcinolone acetonide for the treatment of pseudophakic cystoid macular edema in diabetic patients[J]. DRUG DESIGN DEVELOPMENT AND THERAPY,2014,8:1441-1449.
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