IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
Synthesis of Well-Dispersed Aqueous-Phase Magnetite Nanoparticles and Their Metabolism as an MRI Contrast Agent for the Reticuloendothelial System
Song, Yujun1; Wang, Ruixue2; Rong, Rong3; Ding, Jie1; Liu, Jing3; Li, Runsheng1; Liu, Zhenghua3; Li, Hao1; Wang, Xiaoying3; Zhang, Jue2; Fang, Jing2
关键词Nanoparticles Magnetite Aqueous Phase Metabolism Magnetic Resonance Imaging Magnetic Properties Reticuloendothelial System
刊名EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
2011-08-01
DOI10.1002/ejic.201100017
22页:3303-3313
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Inorganic & Nuclear
研究领域[WOS]Chemistry
关键词[WOS]IRON-OXIDE NANOPARTICLES ; THERMAL-DECOMPOSITION ; FE3O4 ; FUNCTIONALIZATION ; NANOCRYSTALS ; CHEMISTRY ; RESONANCE ; MN ; FE ; CO
英文摘要

Aqueous-phase Fe(3)O(4) nanoparticles (NPs), with a size of 9.8 +/- 3.0 nm, are directly synthesized by a modified iron salt coprecipitation process, stabilized by the synergistic effect of a combination of poly(vinylpyrrolidone) (PVP), trisodium citrate (TSC), and maleic anhydride (MAH). These NPs show good aqueous-phase dispersion stability and excellent superparamagnetic properties with a saturation magnetization of 48.0 emu/g at a low magnetic field of 0.5 T. Their biocompatibility and metabolism for application in magnetic resonance reticuloendothelial system examinations are investigated by using rabbits as animal models for the determination of optimized dosage and diagnosis time for the enhanced imaging contrast for the early diagnosis of diseases. Results indicate that a significant darkening effect on the liver epithelial net lymph tissue can be observed in less than 30 min, with about 20% reduction of the spin-spin relaxation time of T(2) after injection. A metabolism study on the NPs indicates that they show little toxicity to the living organs examined, and finally enter into the spleen without obvious retention in any related organs after recycling for more than 2 d.

语种英语
WOS记录号WOS:000293299100005
项目编号2008KR1330 ; 10774009 ; 2006CB910706 ; 50971010 ; YWF-11-03-Q-002 ; 2008-00061025
资助机构Peking University Biomed-X Foundation ; China International Science and Technology Cooperation ; National Natural Science Foundation of China ; National Basic Research Program of China ; Fundamental Research Funds for the Central Universities in China ; National Natural Science Foundation of China (NSFC) ; Beihang University ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (SRF for ROCS, SEM)
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55293
专题北京大学第一临床医学院_放射治疗科
北京大学第一临床医学院_医学影像科
作者单位1.Beihang Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Aerosp Mat & Performance, Beijing 100191, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Song, Yujun,Wang, Ruixue,Rong, Rong,et al. Synthesis of Well-Dispersed Aqueous-Phase Magnetite Nanoparticles and Their Metabolism as an MRI Contrast Agent for the Reticuloendothelial System[J]. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,2011(22):3303-3313.
APA Song, Yujun.,Wang, Ruixue.,Rong, Rong.,Ding, Jie.,Liu, Jing.,...&Fang, Jing.(2011).Synthesis of Well-Dispersed Aqueous-Phase Magnetite Nanoparticles and Their Metabolism as an MRI Contrast Agent for the Reticuloendothelial System.EUROPEAN JOURNAL OF INORGANIC CHEMISTRY(22),3303-3313.
MLA Song, Yujun,et al."Synthesis of Well-Dispersed Aqueous-Phase Magnetite Nanoparticles and Their Metabolism as an MRI Contrast Agent for the Reticuloendothelial System".EUROPEAN JOURNAL OF INORGANIC CHEMISTRY .22(2011):3303-3313.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Song, Yujun]的文章
[Wang, Ruixue]的文章
[Rong, Rong]的文章
百度学术
百度学术中相似的文章
[Song, Yujun]的文章
[Wang, Ruixue]的文章
[Rong, Rong]的文章
必应学术
必应学术中相似的文章
[Song, Yujun]的文章
[Wang, Ruixue]的文章
[Rong, Rong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。