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学科主题: 临床医学
题名:
Synthesis of Well-Dispersed Aqueous-Phase Magnetite Nanoparticles and Their Metabolism as an MRI Contrast Agent for the Reticuloendothelial System
作者: Song, Yujun1; Wang, Ruixue2; Rong, Rong3; Ding, Jie1; Liu, Jing3; Li, Runsheng1; Liu, Zhenghua3; Li, Hao1; Wang, Xiaoying3; Zhang, Jue2; Fang, Jing2
关键词: Nanoparticles ; Magnetite ; Aqueous phase ; Metabolism ; Magnetic resonance imaging ; Magnetic properties ; Reticuloendothelial system
刊名: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
发表日期: 2011-08-01
DOI: 10.1002/ejic.201100017
期: 22, 页:3303-3313
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Inorganic & Nuclear
研究领域[WOS]: Chemistry
关键词[WOS]: IRON-OXIDE NANOPARTICLES ; THERMAL-DECOMPOSITION ; FE3O4 ; FUNCTIONALIZATION ; NANOCRYSTALS ; CHEMISTRY ; RESONANCE ; MN ; FE ; CO
英文摘要:

Aqueous-phase Fe(3)O(4) nanoparticles (NPs), with a size of 9.8 +/- 3.0 nm, are directly synthesized by a modified iron salt coprecipitation process, stabilized by the synergistic effect of a combination of poly(vinylpyrrolidone) (PVP), trisodium citrate (TSC), and maleic anhydride (MAH). These NPs show good aqueous-phase dispersion stability and excellent superparamagnetic properties with a saturation magnetization of 48.0 emu/g at a low magnetic field of 0.5 T. Their biocompatibility and metabolism for application in magnetic resonance reticuloendothelial system examinations are investigated by using rabbits as animal models for the determination of optimized dosage and diagnosis time for the enhanced imaging contrast for the early diagnosis of diseases. Results indicate that a significant darkening effect on the liver epithelial net lymph tissue can be observed in less than 30 min, with about 20% reduction of the spin-spin relaxation time of T(2) after injection. A metabolism study on the NPs indicates that they show little toxicity to the living organs examined, and finally enter into the spleen without obvious retention in any related organs after recycling for more than 2 d.

语种: 英语
所属项目编号: 2008KR1330 ; 10774009 ; 2006CB910706 ; 50971010 ; YWF-11-03-Q-002 ; 2008-00061025
项目资助者: Peking University Biomed-X Foundation ; China International Science and Technology Cooperation ; National Natural Science Foundation of China ; National Basic Research Program of China ; Fundamental Research Funds for the Central Universities in China ; National Natural Science Foundation of China (NSFC) ; Beihang University ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry (SRF for ROCS, SEM)
WOS记录号: WOS:000293299100005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55293
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Beihang Univ, Sch Mat Sci & Engn, Minist Educ, Key Lab Aerosp Mat & Performance, Beijing 100191, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100034, Peoples R China

Recommended Citation:
Song, Yujun,Wang, Ruixue,Rong, Rong,et al. Synthesis of Well-Dispersed Aqueous-Phase Magnetite Nanoparticles and Their Metabolism as an MRI Contrast Agent for the Reticuloendothelial System[J]. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY,2011(22):3303-3313.
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