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学科主题临床医学
Effects of Huanshuai Recipe Oral Liquid (sic) on Restructuring Glomerular Microvasculature and Expression of Vascular Endothelial Growth Factor in Subtotal Nephrectomized Rats
Li Shen1; Rao Xiang-rong1; Song Jin-ye2,3; Meng Li-qiang2,3; Qu Lei2,3; Li Xiao-mei2,3
关键词Huanshuai Recipe Oral Liquid Restructuring Glomerular Microvasculature Vascular Endothelial Growth Factor
刊名CHINESE JOURNAL OF INTEGRATIVE MEDICINE
2010-06-01
DOI10.1007/s11655-010-0239-4
16期:3页:239-246
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]CHRONIC KIDNEY-DISEASE ; IMPAIRED ANGIOGENESIS ; MESANGIAL CELLS ; MODEL ; VEGF ; PATHOGENESIS ; REGRESSION ; FIBROSIS
英文摘要

Objectives: To explore the effects and significance of Huanshuai Recipe Oral Liquid (sic) , HSR), a formula with supplementing qi, nourishing blood and activating blood on restructuring glomerular microvasculature and expression of vascular endothelial growth factor (VEGF) in subtotal nephrectomized (SNX) rats. Methods: A total of 76 male Wistar rats were randomly divided into four groups: 16 in the sham-operated group and fed with tap water 10 mL/kg per day; 20 in the model group were operated with 5/6 SNX and fed with tap water 10 mL/kg per day; 20 SNX rats in the HSR group were treated with HSR 10 mL/kg per day; 20 SNX rats in the losartan group were treated with losartan 40 mg/kg per day. Serum creatinine (SCr) and urinary protein excretion (Upro) were examined at the 2nd, 4th, 8th, and 12th weeks of the treatment, and the remnant kidneys were harvested. Changes in histological microstructure were evaluated using light microscopy, and the expression of VEGF was detected by using ELISA. Results: Upro, microvasculature injury and glomerulosclerosis were found to be alleviated in HSR and Losartan groups, respectively. The change of VEGF expression showed positive correlation with glomerular capillary area and peritubular capillary number (r=0.448, P<0.01), but negative correlation with that of SCr and Upro (r=-0.592, r=-0.481, P<0.01). Conclusions: HSR could regulate the VEGF expression, reduce the loss of microvasculature, which demonstrated similar renal protective effects to losartan in SNX rats. Examination of Chinese herbal medicine influence on VEGF signaling and restructuring renal microvasculature may elucidate the molecular mechanism of renal protection to a certain degree.

语种英语
WOS记录号WOS:000278215800010
项目编号04-05J007
资助机构Chinese Medicine Science and Technology Research ; State Administration of Traditional Chinese Medicine
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55295
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_放射治疗科
作者单位1.Minist China, Key Lab Publ Hlth, Beijing 100034, Peoples R China
2.China Acad Chinese Med Sci, Guang Anmen Hosp, Beijing 100053, Peoples R China
3.Peking Univ, Dept Renal Nephrol, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
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GB/T 7714
Li Shen,Rao Xiang-rong,Song Jin-ye,et al. Effects of Huanshuai Recipe Oral Liquid (sic) on Restructuring Glomerular Microvasculature and Expression of Vascular Endothelial Growth Factor in Subtotal Nephrectomized Rats[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2010,16(3):239-246.
APA Li Shen,Rao Xiang-rong,Song Jin-ye,Meng Li-qiang,Qu Lei,&Li Xiao-mei.(2010).Effects of Huanshuai Recipe Oral Liquid (sic) on Restructuring Glomerular Microvasculature and Expression of Vascular Endothelial Growth Factor in Subtotal Nephrectomized Rats.CHINESE JOURNAL OF INTEGRATIVE MEDICINE,16(3),239-246.
MLA Li Shen,et al."Effects of Huanshuai Recipe Oral Liquid (sic) on Restructuring Glomerular Microvasculature and Expression of Vascular Endothelial Growth Factor in Subtotal Nephrectomized Rats".CHINESE JOURNAL OF INTEGRATIVE MEDICINE 16.3(2010):239-246.
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