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学科主题: 临床医学
题名:
Effects of Huanshuai Recipe Oral Liquid (sic) on Restructuring Glomerular Microvasculature and Expression of Vascular Endothelial Growth Factor in Subtotal Nephrectomized Rats
作者: Li Shen1; Rao Xiang-rong1; Song Jin-ye2,3; Meng Li-qiang2,3; Qu Lei2,3; Li Xiao-mei2,3
关键词: Huanshuai Recipe Oral Liquid ; restructuring glomerular microvasculature ; vascular endothelial growth factor
刊名: CHINESE JOURNAL OF INTEGRATIVE MEDICINE
发表日期: 2010-06-01
DOI: 10.1007/s11655-010-0239-4
卷: 16, 期:3, 页:239-246
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; IMPAIRED ANGIOGENESIS ; MESANGIAL CELLS ; MODEL ; VEGF ; PATHOGENESIS ; REGRESSION ; FIBROSIS
英文摘要:

Objectives: To explore the effects and significance of Huanshuai Recipe Oral Liquid (sic) , HSR), a formula with supplementing qi, nourishing blood and activating blood on restructuring glomerular microvasculature and expression of vascular endothelial growth factor (VEGF) in subtotal nephrectomized (SNX) rats. Methods: A total of 76 male Wistar rats were randomly divided into four groups: 16 in the sham-operated group and fed with tap water 10 mL/kg per day; 20 in the model group were operated with 5/6 SNX and fed with tap water 10 mL/kg per day; 20 SNX rats in the HSR group were treated with HSR 10 mL/kg per day; 20 SNX rats in the losartan group were treated with losartan 40 mg/kg per day. Serum creatinine (SCr) and urinary protein excretion (Upro) were examined at the 2nd, 4th, 8th, and 12th weeks of the treatment, and the remnant kidneys were harvested. Changes in histological microstructure were evaluated using light microscopy, and the expression of VEGF was detected by using ELISA. Results: Upro, microvasculature injury and glomerulosclerosis were found to be alleviated in HSR and Losartan groups, respectively. The change of VEGF expression showed positive correlation with glomerular capillary area and peritubular capillary number (r=0.448, P<0.01), but negative correlation with that of SCr and Upro (r=-0.592, r=-0.481, P<0.01). Conclusions: HSR could regulate the VEGF expression, reduce the loss of microvasculature, which demonstrated similar renal protective effects to losartan in SNX rats. Examination of Chinese herbal medicine influence on VEGF signaling and restructuring renal microvasculature may elucidate the molecular mechanism of renal protection to a certain degree.

语种: 英语
所属项目编号: 04-05J007
项目资助者: Chinese Medicine Science and Technology Research ; State Administration of Traditional Chinese Medicine
WOS记录号: WOS:000278215800010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55295
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Minist China, Key Lab Publ Hlth, Beijing 100034, Peoples R China
2.China Acad Chinese Med Sci, Guang Anmen Hosp, Beijing 100053, Peoples R China
3.Peking Univ, Dept Renal Nephrol, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China

Recommended Citation:
Li Shen,Rao Xiang-rong,Song Jin-ye,et al. Effects of Huanshuai Recipe Oral Liquid (sic) on Restructuring Glomerular Microvasculature and Expression of Vascular Endothelial Growth Factor in Subtotal Nephrectomized Rats[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2010,16(3):239-246.
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