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学科主题基础医学
Kinetics of thymocyte developmental process in fetal and neonatal mice
Xiao, SY; Li, Y; Chen, WF
关键词fetal thymus neonatal mice thymocyte ontogeny
刊名CELL RESEARCH
2003-08-01
13期:4页:265-273
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]MOUSE THYMUS ; CELL ; DIFFERENTIATION ; PRECURSORS ; PROLIFERATION ; SUBPOPULATION ; INTERMEDIATE ; ONTOGENY
英文摘要

Kinetics of thymocyte development in vivo during embryogenesis was pursued. The early development of thymocytes in the fetal and neonatal BALB/c mice was discontinuous, with four waves of cell proliferation occurring at fetal day (Fd) 14 to 17, Fd 18 to day (D) 1 after birth, D 2 to D 5 and D6 thereafter. The first three proliferation waves coincided with the generation of CD4(hi) CD8(hi) (DP), TCR(+)CD4(hi)CD8(-/lo) (CD4 SP), and TCR(+)CD4(-/lo)CD8(int/hi) (CD8 SP) thymocytes, respectively. The transition from DN to DP cells was further investigated and it was found out that there were two differential pathways via immature single positive (ISP) cells in the BALB/c mice, each functioning at different fetal ages. One is via TCR(-)CD4(-)CD8(+) cells, occurring between Fd 15 and Fd 17 and the other is via TCR(-)CD4(+)CD8(-) cells, occurring from Fd 17 until birth. In contrast, the TCR(-)CD4(-)CD8(+) pathway dominated overwhelmingly in the C57BL/6 mice. These findings shed new light on the hypothesis that the differential pathway preference varies with mouse strains. With respect to the shift in the intensity of CD4 and CD8 expression on thymocytes from fetal to adult mice, the TCR(+)CD4(hi)CD8(-/lo), and TCR(+)CD4(-/lo)CD8(int/hi) subsets might be equivalent to the medullary type TCR(+)CD4/CD8 SP cells.

语种英语
WOS记录号WOS:000185166200006
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55296
Collection北京大学基础医学院_免疫学系
作者单位Peking Univ, Sch Basic Med Sci, Dept Immunol, Hlth Sci Ctr, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Xiao, SY,Li, Y,Chen, WF. Kinetics of thymocyte developmental process in fetal and neonatal mice[J]. CELL RESEARCH,2003,13(4):265-273.
APA Xiao, SY,Li, Y,&Chen, WF.(2003).Kinetics of thymocyte developmental process in fetal and neonatal mice.CELL RESEARCH,13(4),265-273.
MLA Xiao, SY,et al."Kinetics of thymocyte developmental process in fetal and neonatal mice".CELL RESEARCH 13.4(2003):265-273.
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