IR@PKUHSC  > 北京大学第二临床医学院  > 内分泌科
学科主题临床医学
Association between Family History Risk Categories and Prevalence of Diabetes in Chinese Population
Zhang, Jinping1; Yang, Zhaojun1; Xiao, Jianzhong1; Xing, Xiaoyan1; Lu, Juming2; Weng, Jianping3; Jia, Weiping4; Ji, Linong5; Shan, Zhongyan6; Liu, Jie7; Tian, Haoming8; Ji, Qiuhe9; Zhu, Dalong10; Ge, Jiapu11; Chen, Li12; Guo, Xiaohui13; Zhao, Zhigang14; Li, Qiang15; Zhou, Zhiguang16; Lin, Lixiang17; Wang, Na1; Yang, Wenying1; China Natl Diabet Metab Disorders
刊名PLOS ONE
2015-02-09
DOI10.1371/journal.pone.0117044
10期:2
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Chinese Medical Association Foundation ; Chinese Diabetes Society ; Chinese Medical Association Foundation ; Chinese Diabetes Society
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]IMPAIRED GLUCOSE-TOLERANCE ; INSULIN SENSITIVITY ; FASTING GLUCOSE ; SECRETION ; OBESITY ; HYPERINSULINEMIA ; TRANSMISSION ; INDIVIDUALS ; RESISTANCE ; RELATIVES
英文摘要

Aim

To investigate the association between different family history risk categories and prevalence of diabetes in the Chinese population.

Methods

The family history of diabetes was obtained from each subject, and an oral glucose tolerance test was performed for measuring the fasting and postload glucose and insulin levels based on a national representative cross-sectional survey of 46,239 individuals (age >= 20 years) in the 2007-2008 China National Diabetes and Metabolism Disorders Study. The family history risk categories of diabetes were high, moderate, and average (FH2 and FH1: at least two generations and one generation of first-degree relatives with diabetes, respectively; FH0: no first-degree relatives with diabetes).

Results

The age-and gender-adjusted prevalence rates of diabetes were 32.7% (95% confidence interval (CI): 26.4-39.7%) in FH2, 20.1% (95% CI: 18.2-22.1%) in FH1, and 8.4% (95% CI: 7.9-8.9%) in FH0 (P < 0.0001). The calculated homeostatic model assessment-estimated insulin resistance (HOMA-IR), Matsuda insulin sensitivity index (ISI), and insulinogenic index (Delta I30/Delta G30) values showed significant trending changes among the three risk categories, with the most negative effects in FH2. Multivariate logistic regression analysis showed that the odds ratios of having diabetes were 6.16 (95% CI: 4.46-8.50) and 2.86 (95% CI: 2.41-3.39) times higher in FH2 and FH1, respectively, than in FH0 after adjustment for classical risk factors for diabetes.

Conclusions

Family history risk categories of diabetes have a significant, independent, and graded association with the prevalence of this disease in the Chinese population.

语种英语
所属项目编号07020470055
资助者Chinese Medical Association Foundation ; Chinese Diabetes Society ; Chinese Medical Association Foundation ; Chinese Diabetes Society
WOS记录号WOS:000349123100017
Citation statistics
Cited Times:8[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55309
Collection北京大学第二临床医学院_内分泌科
作者单位1.China Japan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
3.Sun Yat Sen Univ, Hosp 3, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China
4.Fujian Prov Hosp, Dept Endocrinol, Fuzhou, Fujiang, Peoples R China
5.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Endocrinol, Shanghai 200030, Peoples R China
6.Peking Univ, Peoples Hosp, Dept Endocrinol, Beijing 100871, Peoples R China
7.Chinese Med Univ, Affiliated Hosp 1, Dept Endocrinol, Liaoling, Peoples R China
8.Shanxi Prov Peoples Hosp, Dept Endocrinol, Taiyuan, Shanxi, Peoples R China
9.Sichuan Univ, West China Hosp, Dept Endocrinol, Chengdu 610064, Sichuan, Peoples R China
10.Fourth Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian 710032, Shanxi, Peoples R China
11.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Dept Endocrinol, Nanjing 210008, Jiangsu, Peoples R China
12.Xinjiang Uygur Autonomous Reg Hosp, Dept Endocrinol, Urumqi, Xinjiang, Peoples R China
13.Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan 250100, Shandong, Peoples R China
14.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100871, Peoples R China
15.Henan Prov Peoples Hosp, Dept Endocrinol, Zhengzhou, Henan, Peoples R China
16.Harbin Med Univ, Affiliated Hosp 2, Dept Endocrinol, Harbin, Heilongjiang, Peoples R China
17.Xiangya Second Hosp, Dept Endocrinol, Changsha, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jinping,Yang, Zhaojun,Xiao, Jianzhong,et al. Association between Family History Risk Categories and Prevalence of Diabetes in Chinese Population[J]. PLOS ONE,2015,10(2).
APA Zhang, Jinping.,Yang, Zhaojun.,Xiao, Jianzhong.,Xing, Xiaoyan.,Lu, Juming.,...&China Natl Diabet Metab Disorders.(2015).Association between Family History Risk Categories and Prevalence of Diabetes in Chinese Population.PLOS ONE,10(2).
MLA Zhang, Jinping,et al."Association between Family History Risk Categories and Prevalence of Diabetes in Chinese Population".PLOS ONE 10.2(2015).
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