IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
CD3(+) cell dose and disease status are important factors determining clinical undergoing unmanipulated outcomes in patients haploidentical blood and including marrow transplantation after conditioning antithymocyte globulin
Dong, Lujia; Wu, Tong; Zhang, Mei-Jie; Gao, Zhi-Yong; Lu, Dao-Pei
关键词Allogeneic Transplantation Cd3(+) Cell Dose Hla-mismatched/haploidentical Leukemia
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2007-12-01
DOI10.1016/j.bbmt.2007.09.007
13期:12页:1515-1524
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]MESENCHYMAL STEM-CELLS ; VERSUS-HOST-DISEASE ; COLONY-STIMULATING FACTOR ; BONE-MARROW ; PERIPHERAL-BLOOD ; G-CSF ; STROMAL CELLS ; SIBLING TRANSPLANTATION ; ACUTE-LEUKEMIA ; CHRONIC GRAFT
英文摘要

Haploidentical transplantation is a feasible alternative for patients with life-threatening hematologic diseases who lack a matched donor. Factors affecting the clinical outcomes of haploidentical transplantation remain under investigation. We analyzed 157 consecutive patients with leukemia who underwent transplantation with nonmanipulated granulocyte colony-stimulating factor (G-CSF)-mobilized marrow and peripheral blood cells (G-BMPBs) from haploidentical donors after receiving myeloablative chemotherapy (Ara-C + BuCy + antithymocyte globulin). Follow up observations after transplantation were made from 48 days to 1191 days (median, 448 days). Multivariate analysis indicated that the cohort given higher doses of CD3(+) cells (>= 177 x 10(6)/kg) in allograft transplantation had a significantly lower treatment-related mortality (TRM) (relative risk [RR] = 0.35; 95% CI = 0.16-0.77; P = .0090), better leukemia-free survival (LFS) (RR = 0.46; 95% CI = 0.26-0.84; P = .0106), and better overall survival (OS) (RR = 0.42; 95% CI = 0.23-0.78; P = .0058). Inversely, advanced-stage disease was a strong predictor of greater posttransplantation relapse (RR = 3.48; 95% CI = 1.26- 9.60; P = .0159), worse LFS (RR = 2.56; 95% CI = 1.33-4.95; P = .0050), and worse OS (RR = 2.77; 95% CI = 1.39-5.53; P = .0038). A high number of CD3(+) cells (> 177 x 10(6)/kg) given to patients resulted in statistically less TRM and more intensive graft versus leukemia effect without producing more severe grades of GVHD, all resulting in a significantly better overall clinical outcome from haploidentical transplantation. (c) 2007 American Society for Blood and Marrow Transplantation.

语种英语
WOS记录号WOS:000251495900014
引用统计
被引频次:24[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55310
专题北京大学第二临床医学院
作者单位1.Dao Pei Hosp, Beijing, Peoples R China
2.Med Coll Wisconsin, Div Biostat, Milwaukee, WI 53226 USA
3.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Dong, Lujia,Wu, Tong,Zhang, Mei-Jie,et al. CD3(+) cell dose and disease status are important factors determining clinical undergoing unmanipulated outcomes in patients haploidentical blood and including marrow transplantation after conditioning antithymocyte globulin[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2007,13(12):1515-1524.
APA Dong, Lujia,Wu, Tong,Zhang, Mei-Jie,Gao, Zhi-Yong,&Lu, Dao-Pei.(2007).CD3(+) cell dose and disease status are important factors determining clinical undergoing unmanipulated outcomes in patients haploidentical blood and including marrow transplantation after conditioning antithymocyte globulin.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,13(12),1515-1524.
MLA Dong, Lujia,et al."CD3(+) cell dose and disease status are important factors determining clinical undergoing unmanipulated outcomes in patients haploidentical blood and including marrow transplantation after conditioning antithymocyte globulin".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 13.12(2007):1515-1524.
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