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学科主题: 临床医学
题名:
Treating donor mice with rhIL-11 and rhG-CSF promotes transplant-tolerance and preserves the effects of GVL after allogeneic bone marrow transplantation
作者: Huang, Xiao-Jun1; Zhao, Jie; Zhao, Xiang-Yu; Chang, Ying-Jun
关键词: Combination ; Graft-versus-host disease ; Graft-versus-leukemia effect ; Recombinant human granulocyte colony-stimulating factor ; Recombinant human interleukin-11 ; T cell
刊名: LEUKEMIA RESEARCH
发表日期: 2009
DOI: 10.1016/j.leukres.2008.06.009
卷: 33, 期:1, 页:123-128
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: VERSUS-HOST-DISEASE ; COLONY-STIMULATING FACTOR ; STEM-CELL TRANSPLANTATION ; T-CELLS ; LEUKEMIA ; BLOOD ; MALIGNANCIES ; INDUCTION ; PHENOTYPE ; ANTIGENS
英文摘要:

We investigated the impact of recombinant human interleukin-11 (rhIL-11) and granulocyte colony-stimulating factor (rhG-CSF) on bone marrow transplantation. Treatments for leukemic mice were (A) no treatment, (B) mock transplantation, and transplantation from the following donors: (C1) syngeneic, (C) controls, (D) rhG-CSF treated, (E) rhIL-11 treated, and (F) rhIL-11 and rhG-CSF treated. Graft-versus-host disease incidences were 100%, 60%, 78%, and 30% in C, D, E, and F, respectively. The 30 d leukemia-free survival improved significantly in F (70%) compared to C (0%), D (40%), and E (20%) (P < 0.01). Thus, treating donor mice with rhIL-11 and rhG-CSF promoted transplant-tolerance and recipient survival. (C) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30725038 ; NCET-04-0011 ; 2006AA02Z4A0
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; trans-Century Training Programme Foundation ; HiTech Research Development Program of China
WOS记录号: WOS:000261680400017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55313
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Huang, Xiao-Jun,Zhao, Jie,Zhao, Xiang-Yu,et al. Treating donor mice with rhIL-11 and rhG-CSF promotes transplant-tolerance and preserves the effects of GVL after allogeneic bone marrow transplantation[J]. LEUKEMIA RESEARCH,2009,33(1):123-128.
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