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Treating donor mice with rhIL-11 and rhG-CSF promotes transplant-tolerance and preserves the effects of GVL after allogeneic bone marrow transplantation
Huang, Xiao-Jun1; Zhao, Jie; Zhao, Xiang-Yu; Chang, Ying-Jun
关键词Combination Graft-versus-host Disease Graft-versus-leukemia Effect Recombinant Human Granulocyte Colony-stimulating Factor Recombinant Human Interleukin-11 t Cell
刊名LEUKEMIA RESEARCH
2009
DOI10.1016/j.leukres.2008.06.009
33期:1页:123-128
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]VERSUS-HOST-DISEASE ; COLONY-STIMULATING FACTOR ; STEM-CELL TRANSPLANTATION ; T-CELLS ; LEUKEMIA ; BLOOD ; MALIGNANCIES ; INDUCTION ; PHENOTYPE ; ANTIGENS
英文摘要

We investigated the impact of recombinant human interleukin-11 (rhIL-11) and granulocyte colony-stimulating factor (rhG-CSF) on bone marrow transplantation. Treatments for leukemic mice were (A) no treatment, (B) mock transplantation, and transplantation from the following donors: (C1) syngeneic, (C) controls, (D) rhG-CSF treated, (E) rhIL-11 treated, and (F) rhIL-11 and rhG-CSF treated. Graft-versus-host disease incidences were 100%, 60%, 78%, and 30% in C, D, E, and F, respectively. The 30 d leukemia-free survival improved significantly in F (70%) compared to C (0%), D (40%), and E (20%) (P < 0.01). Thus, treating donor mice with rhIL-11 and rhG-CSF promoted transplant-tolerance and recipient survival. (C) 2008 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000261680400017
项目编号30725038 ; NCET-04-0011 ; 2006AA02Z4A0
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; trans-Century Training Programme Foundation ; HiTech Research Development Program of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55313
专题北京大学第二临床医学院
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Univ, Inst Hematol, Beijing 100044, Peoples R China
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Huang, Xiao-Jun,Zhao, Jie,Zhao, Xiang-Yu,et al. Treating donor mice with rhIL-11 and rhG-CSF promotes transplant-tolerance and preserves the effects of GVL after allogeneic bone marrow transplantation[J]. LEUKEMIA RESEARCH,2009,33(1):123-128.
APA Huang, Xiao-Jun,Zhao, Jie,Zhao, Xiang-Yu,&Chang, Ying-Jun.(2009).Treating donor mice with rhIL-11 and rhG-CSF promotes transplant-tolerance and preserves the effects of GVL after allogeneic bone marrow transplantation.LEUKEMIA RESEARCH,33(1),123-128.
MLA Huang, Xiao-Jun,et al."Treating donor mice with rhIL-11 and rhG-CSF promotes transplant-tolerance and preserves the effects of GVL after allogeneic bone marrow transplantation".LEUKEMIA RESEARCH 33.1(2009):123-128.
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