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学科主题: 临床医学
题名:
Modulation of tropoelastin and fibrillin-1 by infrared radiation in human skin in vivo
作者: Chen, Zhou1; Zhuo, Feng-Lin1; Zhang, Shang-Jun2; Tian, Yan3; Tian, Shan1; Zhang, Jian-Zhong1
关键词: fibrillin-1 ; human skin ; infrared radiation ; tropoelastin
刊名: PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
发表日期: 2009-12-01
卷: 25, 期:6, 页:310-316
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: ELASTIC FIBERS ; IRRADIATION ; EXPRESSION
英文摘要:

Background

The heat produced by exposure to infrared radiation (IR) has been demonstrated to modulate the expression of tropoelastin and fibrillin-1, the two main components of elastic fibers in human skin in vivo. However, the effect of IR range of radiations on tropoelastin and fibrillin-1 expression has not been thoroughly investigated.

Methods

Eighteen volunteers were enrolled in this study involving three trials. Time-dependent, dose-dependent and cumulative effects of IR were investigated, respectively. Tropoelastin and fibrillin-1 expression was measured by immunohistochemical staining on skin biopsy samples from volunteers. In addition, we also measured tropoelastin mRNA expression by a real-time RT-polymerase chain reaction.

Results

A single dose of IR (2 minimal heating dose) induced a time-dependent increase in tropoelastin expression at the protein level. An inverse correlation was found between the alterations of tropoelastin and fibrillin-1. Furthermore, IR was found to increase tropoelastin expression in a dose-dependent manner at both the mRNA and the protein level. Repeated low doses of IR increased tropoelastin expression and decreased fibrillin-1 expression at the protein level in the dermis. Meanwhile, the number of both fibers along the dermal-epidermal junction was increased.

Conclusion

IR can alter the expression of tropoelastin and fibrillin-1, which may result in abnormal elastic fiber formation.

语种: 英语
所属项目编号: S 2007040815
项目资助者: CMA-L&prime ; OREAL China Skin
WOS记录号: WOS:000271646200005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55317
Appears in Collections:北京大学第二临床医学院_皮科_期刊论文

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作者单位: 1.Gen Hosp AF, Dept Dermatol, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
3.Peking Univ, Shou Gang Hosp, Dept Dermatol, Beijing 100044, Peoples R China

Recommended Citation:
Chen, Zhou,Zhuo, Feng-Lin,Zhang, Shang-Jun,et al. Modulation of tropoelastin and fibrillin-1 by infrared radiation in human skin in vivo[J]. PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE,2009,25(6):310-316.
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