IR@PKUHSC  > 北京大学第二临床医学院  > 皮科
学科主题临床医学
Modulation of tropoelastin and fibrillin-1 by infrared radiation in human skin in vivo
Chen, Zhou1; Zhuo, Feng-Lin1; Zhang, Shang-Jun2; Tian, Yan3; Tian, Shan1; Zhang, Jian-Zhong1
关键词Fibrillin-1 Human Skin Infrared Radiation Tropoelastin
刊名PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
2009-12-01
25期:6页:310-316
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dermatology
资助者CMA-L&prime ; OREAL China Skin ; CMA-L&prime ; OREAL China Skin
研究领域[WOS]Dermatology
关键词[WOS]ELASTIC FIBERS ; IRRADIATION ; EXPRESSION
英文摘要

Background

The heat produced by exposure to infrared radiation (IR) has been demonstrated to modulate the expression of tropoelastin and fibrillin-1, the two main components of elastic fibers in human skin in vivo. However, the effect of IR range of radiations on tropoelastin and fibrillin-1 expression has not been thoroughly investigated.

Methods

Eighteen volunteers were enrolled in this study involving three trials. Time-dependent, dose-dependent and cumulative effects of IR were investigated, respectively. Tropoelastin and fibrillin-1 expression was measured by immunohistochemical staining on skin biopsy samples from volunteers. In addition, we also measured tropoelastin mRNA expression by a real-time RT-polymerase chain reaction.

Results

A single dose of IR (2 minimal heating dose) induced a time-dependent increase in tropoelastin expression at the protein level. An inverse correlation was found between the alterations of tropoelastin and fibrillin-1. Furthermore, IR was found to increase tropoelastin expression in a dose-dependent manner at both the mRNA and the protein level. Repeated low doses of IR increased tropoelastin expression and decreased fibrillin-1 expression at the protein level in the dermis. Meanwhile, the number of both fibers along the dermal-epidermal junction was increased.

Conclusion

IR can alter the expression of tropoelastin and fibrillin-1, which may result in abnormal elastic fiber formation.

语种英语
所属项目编号S 2007040815
资助者CMA-L&prime ; OREAL China Skin ; CMA-L&prime ; OREAL China Skin
WOS记录号WOS:000271646200005
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55317
Collection北京大学第二临床医学院_皮科
作者单位1.Gen Hosp AF, Dept Dermatol, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Dermatol, Beijing 100044, Peoples R China
3.Peking Univ, Shou Gang Hosp, Dept Dermatol, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Chen, Zhou,Zhuo, Feng-Lin,Zhang, Shang-Jun,et al. Modulation of tropoelastin and fibrillin-1 by infrared radiation in human skin in vivo[J]. PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE,2009,25(6):310-316.
APA Chen, Zhou,Zhuo, Feng-Lin,Zhang, Shang-Jun,Tian, Yan,Tian, Shan,&Zhang, Jian-Zhong.(2009).Modulation of tropoelastin and fibrillin-1 by infrared radiation in human skin in vivo.PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE,25(6),310-316.
MLA Chen, Zhou,et al."Modulation of tropoelastin and fibrillin-1 by infrared radiation in human skin in vivo".PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE 25.6(2009):310-316.
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