IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy
Zhou, Jingjing1,2,3,4; Chen, Yuqing1,2,3,4; Liu, Ying1,2,3,4; Shi, Sufang1,2,3,4; Li, Xueying5; Wang, Suxia6; Zhang, Hong1,2,3,4
关键词Iga Nephropathy Plasma Uric Acid Levels Tubulointerstitial Lesions
刊名BMC NEPHROLOGY
2014-01-14
DOI10.1186/1471-2369-15-11
15
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]IMMUNOGLOBULIN-A NEPHROPATHY ; TERM-FOLLOW-UP ; OXFORD CLASSIFICATION ; NATURAL-HISTORY ; KIDNEY-DISEASE ; RISK-FACTOR ; HYPERURICEMIA ; PROGNOSIS ; PROGRESSION ; GOUT
英文摘要

Background: Hyperuricemia appeared to be a common symptom in IgA nephropathy (IgAN), even in those with normal eGFR. IgAN was characterized by variation of pathological features, especially variable tubulointerstitial lesions. Since tubular reabsorption and excretion appeared to be more important in determination of plasma uric acid levels in persons without obvious decrease of glomerular filtration rate, we took advantage of our IgAN cohort to investigate whether plasma uric acid level associated with tubular interstitial lesions, and could be considered as a maker for tubular interstitial lesions, especially at early stage with normal eGFR.

Methods: 623 IgAN patients were involved in the present study. Morphological changes were evaluated with Oxford classification scoring system as well as Beijing classification system of IgAN. Statistical analysis was done with SPSS 13.0.

Results: We found that plasma uric acid level associated with percentage of interstitial fibrosis/tubular atrophy. Higher plasma uric acid levels indicated higher tubulointerstitial scores, either with Oxford system (P = 0.012) or with Beijing classification system (P = 4.8*10(-4)) in the whole cohort. We also found that in the subgroup of 258 IgAN cases with normal baseline eGFR (eGFR > = 90 ml/min/1.73 M-2), higher plasma uric acid associated with more severe tubulointerstitial lesions with Beijing scoring system (P = 3.4*10(-5)). The risk of having more than 10% tubulointerstitial lesions in patients with hyperuricemia increased 58% compared with normal uric acid level. In subgroup with normal eGFR, only hyperuricemia predicted tubulointerstitial leisions, and the risk of having more tubulointerstitial changes increased 100%. Among these patients, hyperuricemia was associated with more tubulointerstitial lesions with a specificity of 60.3%. Specificity increased to 65% among those patients with eGFR > = 90 ml/min/1.73 m(2).

Conclusions: Plasma uric acid levels indicate tubular interstitial lesions in IgAN and hyperuricemia may be considered as a marker for tubulointerstitial lesions.

语种英语
WOS记录号WOS:000329754300001
资助机构Medical Development of the Capital
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55322
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_电镜室
北京大学第一临床医学院_医学统计室
作者单位1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Minist Educ, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing 100034, Peoples R China
5.Peking Univ, Hosp 1, Dept Stat, Beijing 100034, Peoples R China
6.Peking Univ, Hosp 1, Electron Microscopy Lab, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Jingjing,Chen, Yuqing,Liu, Ying,et al. Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy[J]. BMC NEPHROLOGY,2014,15.
APA Zhou, Jingjing.,Chen, Yuqing.,Liu, Ying.,Shi, Sufang.,Li, Xueying.,...&Zhang, Hong.(2014).Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy.BMC NEPHROLOGY,15.
MLA Zhou, Jingjing,et al."Plasma uric acid level indicates tubular interstitial leisions at early stage of IgA nephropathy".BMC NEPHROLOGY 15(2014).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhou, Jingjing]的文章
[Chen, Yuqing]的文章
[Liu, Ying]的文章
百度学术
百度学术中相似的文章
[Zhou, Jingjing]的文章
[Chen, Yuqing]的文章
[Liu, Ying]的文章
必应学术
必应学术中相似的文章
[Zhou, Jingjing]的文章
[Chen, Yuqing]的文章
[Liu, Ying]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。