IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant protein-1 secretion in monocytes/macrophages
Dai, Jing1; Wang, Xiaofei1; Feng, Juan1; Kong, Wei1; Xu, Qingbo2; Shen, Xun3; Wang, Xian1
关键词Atherosclerosis Chemokine Antioxidation Macrophage Thioredoxin
刊名FEBS LETTERS
2008-11-26
DOI10.1016/j.febslet.2008.10.030
582期:28页:3893-3898
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
资助者National Basic Research Program ; Key Program of National Natural Science Foundation ; 111 Project ; Chang Jiang Scholars Program ; National Basic Research Program ; Key Program of National Natural Science Foundation ; 111 Project ; Chang Jiang Scholars Program
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]HYDROGEN-PEROXIDE ; ATHEROSCLEROSIS ; HYPERHOMOCYSTEINEMIA ; INFLAMMATION ; EXPRESSION ; CELLS
英文摘要

We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Here, we show that Hcy upregulates expression of an important antioxidative protein, thioredoxin (Trx), via NADPH oxidase in human monocytes in vitro. The increase of Trx expression and activity inhibited Hcy-induced ROS production and MCP-1 secretion. Of note, 2-week hyperhomocysteinemia (HHcy) ApoE(-/-) mice showed accelerated lesion formation and parallel lower Trx expression in macrophages than ApoE(-/-) mice, suggesting that HHcy-induced sustained oxidative stress in vivo might account for impaired Trx and hence increased ROS production and MCP-1 secretion from macrophages, and subsequently accelerated atherogenesis. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种英语
所属项目编号2006CB503802 ; 30730042 ; B07001
资助者National Basic Research Program ; Key Program of National Natural Science Foundation ; 111 Project ; Chang Jiang Scholars Program ; National Basic Research Program ; Key Program of National Natural Science Foundation ; 111 Project ; Chang Jiang Scholars Program
WOS记录号WOS:000261235000010
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55323
Collection北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100083, Peoples R China
2.Kings Coll London, James Black Ctr, Div Cardiovasc, London SE5 9NU, England
3.Chinese Acad Sci, Inst Biophys, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Dai, Jing,Wang, Xiaofei,Feng, Juan,et al. Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant protein-1 secretion in monocytes/macrophages[J]. FEBS LETTERS,2008,582(28):3893-3898.
APA Dai, Jing.,Wang, Xiaofei.,Feng, Juan.,Kong, Wei.,Xu, Qingbo.,...&Wang, Xian.(2008).Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant protein-1 secretion in monocytes/macrophages.FEBS LETTERS,582(28),3893-3898.
MLA Dai, Jing,et al."Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant protein-1 secretion in monocytes/macrophages".FEBS LETTERS 582.28(2008):3893-3898.
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