北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 期刊论文
学科主题: 基础医学
题名:
Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant protein-1 secretion in monocytes/macrophages
作者: Dai, Jing1; Wang, Xiaofei1; Feng, Juan1; Kong, Wei1; Xu, Qingbo2; Shen, Xun3; Wang, Xian1
关键词: Atherosclerosis ; Chemokine ; Antioxidation ; Macrophage ; Thioredoxin
刊名: FEBS LETTERS
发表日期: 2008-11-26
DOI: 10.1016/j.febslet.2008.10.030
卷: 582, 期:28, 页:3893-3898
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
关键词[WOS]: HYDROGEN-PEROXIDE ; ATHEROSCLEROSIS ; HYPERHOMOCYSTEINEMIA ; INFLAMMATION ; EXPRESSION ; CELLS
英文摘要:

We have previously shown that homocysteine (Hcy) can induce monocyte chemoattractant protein-1 (MCP-1) secretion via reactive oxygen species (ROS) in human monocytes. Here, we show that Hcy upregulates expression of an important antioxidative protein, thioredoxin (Trx), via NADPH oxidase in human monocytes in vitro. The increase of Trx expression and activity inhibited Hcy-induced ROS production and MCP-1 secretion. Of note, 2-week hyperhomocysteinemia (HHcy) ApoE(-/-) mice showed accelerated lesion formation and parallel lower Trx expression in macrophages than ApoE(-/-) mice, suggesting that HHcy-induced sustained oxidative stress in vivo might account for impaired Trx and hence increased ROS production and MCP-1 secretion from macrophages, and subsequently accelerated atherogenesis. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2006CB503802 ; 30730042 ; B07001
项目资助者: National Basic Research Program ; Key Program of National Natural Science Foundation ; 111 Project ; Chang Jiang Scholars Program
WOS记录号: WOS:000261235000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55323
Appears in Collections:基础医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100083, Peoples R China
2.Kings Coll London, James Black Ctr, Div Cardiovasc, London SE5 9NU, England
3.Chinese Acad Sci, Inst Biophys, Beijing 100080, Peoples R China

Recommended Citation:
Dai, Jing,Wang, Xiaofei,Feng, Juan,et al. Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant protein-1 secretion in monocytes/macrophages[J]. FEBS LETTERS,2008,582(28):3893-3898.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Dai, Jing]'s Articles
[Wang, Xiaofei]'s Articles
[Feng, Juan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Dai, Jing]‘s Articles
[Wang, Xiaofei]‘s Articles
[Feng, Juan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace