|Call for the use of a common equation for glomerular filtration rate estimation in East and South-East Asia|
|Wang, Xuejing1; Ichihara, Kiyoshi2; Xu, Guobin1; Itoh, Yoshihisa3|
|关键词||Creatinine Ethnicity Glomerular Filtration Rate Chronic Kidney Disease Equation|
|WOS标题词||Science & Technology|
|类目[WOS]||Medical Laboratory Technology|
|研究领域[WOS]||Medical Laboratory Technology|
|关键词[WOS]||CHRONIC KIDNEY-DISEASE ; SERUM CREATININE ; REFERENCE INTERVALS ; RECOMMENDATIONS ; POPULATION|
Background: Estimated glomerular filtration rate (eGFR) is currently calculated using various equations and serum creatinine (SCT) value measured by different assays. Differences among these eGFRs deserve further study.
Methods: Volunteers from eight Asian regions (n = 3283; age 20-65 years, 1454 men, 1829 women) were recruited. The Chronic Kidney Disease Epidemiology Collaboration equation (EPI), Modification of Diet in Renal Disease Study equation (MDRD) for Japanese (MDRDJap) and MDRD for Chinese (MDRDChi) were selected. Jaffe and enzymatic assays were used to measure Scr. Six eGFRs were obtained for each volunteer: EPI equation using Scr value of enzymatic assay (EPI/E) and Jaffe assay (EPI/J); MDRDJap equation using Scr value of the two assays (MDRDJap/E, MDRDJap/J); and MDRDChi equation using Scr value of the two assays (MDRDChi/E, MDRDChi/J).
Results: Neither Scr nor eGFR showed significant regional difference. We compared eGFR calculated using the same equation but with different assays. The medians (2.5%, 97.5%) of eGFR difference were 2.0 (-7, 14) mL/min/1.73 m(2) for EPI, 3.0 (-12.0, 18.0) mL/min/1.73 m(2) for MDRDJap, and 5.0 (-18, 30) mL/min/1.73 m2 for MDRDChi. We also compared eGFR calculated using different equations but with the same assay. The medians (2.5%, 97.5%) of eGFR difference were 11 (-6, 56) mL/min/1.73 m(2) between MDRDChi/E and EPI/E; 26 (9, 35) mL/min/1.73 m(2) between EPI/E and MDRDJap/E; and 39 (22, 65) mL/min/1.73 m(2) between MDRDChi/E and MDRDJap/E, respectively.
Conclusions: eGFR difference caused by using different equations is much larger than that caused by using different Scr assays. A common equation for GFR estimation is encouraged for use in Asians. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
|项目编号||21406015: 2009-2011 ; Z121107005112006|
|资助机构||Committee on Reference Interval and Decision Limit of the IFCC ; Scientific Research Fund by the Ministry of Education, Culture, Sports, Science and Technology of Japan ; JSLM ; Scientific Research Fund of the APFCB ; Beijing Municipal Science and Technology Commission ; APFCB|
|作者单位||1.Peking Univ, Clin Lab, Hosp 1, Beijing 100871, Peoples R China|
2.Asahikawa Med Coll, Clin Lab, Asahikawa, Hokkaido 078, Japan
3.Yamaguchi Univ, Grad Sch Med, Fac Hlth Sci, Ube, Yamaguchi 7558505, Japan
|Wang, Xuejing,Ichihara, Kiyoshi,Xu, Guobin,et al. Call for the use of a common equation for glomerular filtration rate estimation in East and South-East Asia[J]. CLINICAL BIOCHEMISTRY,2014,47(13-14):1214-1219.|
|APA||Wang, Xuejing,Ichihara, Kiyoshi,Xu, Guobin,&Itoh, Yoshihisa.(2014).Call for the use of a common equation for glomerular filtration rate estimation in East and South-East Asia.CLINICAL BIOCHEMISTRY,47(13-14),1214-1219.|
|MLA||Wang, Xuejing,et al."Call for the use of a common equation for glomerular filtration rate estimation in East and South-East Asia".CLINICAL BIOCHEMISTRY 47.13-14(2014):1214-1219.|