北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Call for the use of a common equation for glomerular filtration rate estimation in East and South-East Asia
作者: Wang, Xuejing1; Ichihara, Kiyoshi2; Xu, Guobin1; Itoh, Yoshihisa3
关键词: Creatinine ; Ethnicity ; Glomerular filtration rate ; Chronic kidney disease ; Equation
刊名: CLINICAL BIOCHEMISTRY
发表日期: 2014-09-01
DOI: 10.1016/j.clinbiochem.2014.05.058
卷: 47, 期:13-14, 页:1214-1219
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medical Laboratory Technology
研究领域[WOS]: Medical Laboratory Technology
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; SERUM CREATININE ; REFERENCE INTERVALS ; RECOMMENDATIONS ; POPULATION
英文摘要:

Background: Estimated glomerular filtration rate (eGFR) is currently calculated using various equations and serum creatinine (SCT) value measured by different assays. Differences among these eGFRs deserve further study.

Methods: Volunteers from eight Asian regions (n = 3283; age 20-65 years, 1454 men, 1829 women) were recruited. The Chronic Kidney Disease Epidemiology Collaboration equation (EPI), Modification of Diet in Renal Disease Study equation (MDRD) for Japanese (MDRDJap) and MDRD for Chinese (MDRDChi) were selected. Jaffe and enzymatic assays were used to measure Scr. Six eGFRs were obtained for each volunteer: EPI equation using Scr value of enzymatic assay (EPI/E) and Jaffe assay (EPI/J); MDRDJap equation using Scr value of the two assays (MDRDJap/E, MDRDJap/J); and MDRDChi equation using Scr value of the two assays (MDRDChi/E, MDRDChi/J).

Results: Neither Scr nor eGFR showed significant regional difference. We compared eGFR calculated using the same equation but with different assays. The medians (2.5%, 97.5%) of eGFR difference were 2.0 (-7, 14) mL/min/1.73 m(2) for EPI, 3.0 (-12.0, 18.0) mL/min/1.73 m(2) for MDRDJap, and 5.0 (-18, 30) mL/min/1.73 m2 for MDRDChi. We also compared eGFR calculated using different equations but with the same assay. The medians (2.5%, 97.5%) of eGFR difference were 11 (-6, 56) mL/min/1.73 m(2) between MDRDChi/E and EPI/E; 26 (9, 35) mL/min/1.73 m(2) between EPI/E and MDRDJap/E; and 39 (22, 65) mL/min/1.73 m(2) between MDRDChi/E and MDRDJap/E, respectively.

Conclusions: eGFR difference caused by using different equations is much larger than that caused by using different Scr assays. A common equation for GFR estimation is encouraged for use in Asians. (C) 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 21406015: 2009-2011 ; Z121107005112006
项目资助者: Committee on Reference Interval and Decision Limit of the IFCC ; Scientific Research Fund by the Ministry of Education, Culture, Sports, Science and Technology of Japan ; JSLM ; Scientific Research Fund of the APFCB ; Beijing Municipal Science and Technology Commission ; APFCB
WOS记录号: WOS:000341329000008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55329
Appears in Collections:北京大学第一临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Clin Lab, Hosp 1, Beijing 100871, Peoples R China
2.Asahikawa Med Coll, Clin Lab, Asahikawa, Hokkaido 078, Japan
3.Yamaguchi Univ, Grad Sch Med, Fac Hlth Sci, Ube, Yamaguchi 7558505, Japan

Recommended Citation:
Wang, Xuejing,Ichihara, Kiyoshi,Xu, Guobin,et al. Call for the use of a common equation for glomerular filtration rate estimation in East and South-East Asia[J]. CLINICAL BIOCHEMISTRY,2014,47(13-14):1214-1219.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wang, Xuejing]'s Articles
[Ichihara, Kiyoshi]'s Articles
[Xu, Guobin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wang, Xuejing]‘s Articles
[Ichihara, Kiyoshi]‘s Articles
[Xu, Guobin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace