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IR@PKUHSC  > 北京大学药学院  > 天然药物学系  > 期刊论文
学科主题: 药学
题名:
Itosides J-N from Itoa orientalis and structure - Anti-COX-2 activity relationship of phenolic glycosides
作者: Chai, Xing Yun; Song, Yue Lin; Xu, Zheng Ren; Shi, Hai Ming; Bai, Chang Cai; Bi, Dan; Wen, Jing; Li, Fei Fei; Tu, Peng Fei
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2008-05-01
DOI: 10.1021/np800014s
卷: 71, 期:5, 页:814-819
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: LEAVES ; CONSTITUENTS ; DERIVATIVES ; GLUCOSIDE ; ALCOHOL ; ESTERS
英文摘要:

Two new phenolic glycosides, itosides J (1) and K (2), two new cylcohexenoyl glycosides, itosides L (3) and M (4), a new flavone glycoside, itoside N (5), and echitin (6) were isolated from the extract of the bark, twigs, and leaves of Itoa orientalis, together with 22 known compounds. The structures were elucidated by means of UV, IR, MS, and NMR techniques, and the relative configuration of compound 3 was confirmed by X-ray crystallography. NMR data for 6 are reported for the first time. Compounds 1, 3, 5, and phenolic glycosides 7-22 were also assayed for anti-inflammatory activity against COX-2. Compounds 8, 10, 12-14, 16, 19, 24, 26, and 27 showed significant inhibitory effects, with inhibitory rates of 49.7-85.3% at 10 mu M.

语种: 英语
WOS记录号: WOS:000256180600015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55330
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China

Recommended Citation:
Chai, Xing Yun,Song, Yue Lin,Xu, Zheng Ren,et al. Itosides J-N from Itoa orientalis and structure - Anti-COX-2 activity relationship of phenolic glycosides[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(5):814-819.
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