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Itosides J-N from Itoa orientalis and structure - Anti-COX-2 activity relationship of phenolic glycosides
Chai, Xing Yun; Song, Yue Lin; Xu, Zheng Ren; Shi, Hai Ming; Bai, Chang Cai; Bi, Dan; Wen, Jing; Li, Fei Fei; Tu, Peng Fei
刊名JOURNAL OF NATURAL PRODUCTS
2008-05-01
DOI10.1021/np800014s
71期:5页:814-819
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]LEAVES ; CONSTITUENTS ; DERIVATIVES ; GLUCOSIDE ; ALCOHOL ; ESTERS
英文摘要

Two new phenolic glycosides, itosides J (1) and K (2), two new cylcohexenoyl glycosides, itosides L (3) and M (4), a new flavone glycoside, itoside N (5), and echitin (6) were isolated from the extract of the bark, twigs, and leaves of Itoa orientalis, together with 22 known compounds. The structures were elucidated by means of UV, IR, MS, and NMR techniques, and the relative configuration of compound 3 was confirmed by X-ray crystallography. NMR data for 6 are reported for the first time. Compounds 1, 3, 5, and phenolic glycosides 7-22 were also assayed for anti-inflammatory activity against COX-2. Compounds 8, 10, 12-14, 16, 19, 24, 26, and 27 showed significant inhibitory effects, with inhibitory rates of 49.7-85.3% at 10 mu M.

语种英语
WOS记录号WOS:000256180600015
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55330
专题北京大学药学院_天然药物学系
作者单位Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Chai, Xing Yun,Song, Yue Lin,Xu, Zheng Ren,et al. Itosides J-N from Itoa orientalis and structure - Anti-COX-2 activity relationship of phenolic glycosides[J]. JOURNAL OF NATURAL PRODUCTS,2008,71(5):814-819.
APA Chai, Xing Yun.,Song, Yue Lin.,Xu, Zheng Ren.,Shi, Hai Ming.,Bai, Chang Cai.,...&Tu, Peng Fei.(2008).Itosides J-N from Itoa orientalis and structure - Anti-COX-2 activity relationship of phenolic glycosides.JOURNAL OF NATURAL PRODUCTS,71(5),814-819.
MLA Chai, Xing Yun,et al."Itosides J-N from Itoa orientalis and structure - Anti-COX-2 activity relationship of phenolic glycosides".JOURNAL OF NATURAL PRODUCTS 71.5(2008):814-819.
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