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学科主题: 临床医学
题名:
In vivo comparison between cardiac allograft vasculopathy and native atherosclerosis using near-infrared spectroscopy and intravascular ultrasound
作者: Zheng, Bo1,2,3; Maehara, Akiko1,2; Mintz, Gary S.2; Nazif, Tamim M.1; Waksman, Yarden1; Qiu, Fuyu1,2; Jaquez, Luz1; Rabbani, LeRoy E.1; Apfelbaum, Mark A.1; Ali, Ziad A.1,4; Dalton, Kate1; Xu, Ke2; Marboe, Charles C.1; Mancini, Donna M.1; Weisz, Giora1,2,5
关键词: cardiac allograft vasculopathy ; near-infrared spectroscopy ; intravascular ultrasound ; atherosclerosis
刊名: EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
发表日期: 2015-09-01
DOI: 10.1093/ehjci/jev017
卷: 16, 期:9, 页:985-991
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: PERCUTANEOUS CORONARY INTERVENTION ; ELEVATION MYOCARDIAL-INFARCTION ; OPTICAL COHERENCE TOMOGRAPHY ; LIPID-CORE PLAQUES ; ATTENUATED PLAQUE ; TRANSPLANT RECIPIENTS ; NO-REFLOW ; HEART ; CALCIFICATION ; ARTERIOPATHY
英文摘要:

Aims The aim was to compare cardiac allograft vasculopathy to native atherosclerosis by near-infrared spectroscopyintravascular ultrasound (NIRS-IVUS).

Methods and results Twenty-seven atherosclerotic (non-transplant) patients and 28 heart transplant recipients undergoing routine surveillance coronary angiography underwent NIRS-IVUS imaging of the left anterior descending coronary artery. In each proximal, middle, and distal coronary artery segment, the maxLCBI(4mm) [4-mm long segment with maximum lipid core burden index (LCBI)] and corresponding IVUS parameters were compared. MaxLCBI(4mm) was significantly greater among atherosclerotic patients than the transplant patients in both proximal and middle coronary artery segments, but not in the distal segment. There was a positive linear correlation between maxLCBI(4mm) and maximum plaque burden in both groups, but atherosclerotic patients demonstrated a smaller maxLCBI(4mm) than transplant recipients among segments with plaque burden <40%. Among segments with a maximum plaque burden >= 40%, native-atherosclerosis patients had a greater maxLCBI(4mm) compared with transplant patients (P = 0.015). Calcification was present in 72.9% of native atherosclerosis and 14.7% of transplant segments (P < 0.001). Among the 165 analysed segments, prevalence of lipid-rich plaque (LRP) with superficial attenuation (30.9 vs. 1.2%, P < 0.001) or calcified LRP (13.6 vs. 2.4%, P = 0.03) was significantly greater in native atherosclerosis compared with transplant patients. Conversely, the proportion of segments with non-LRP (46.4 vs. 11.1%, P < 0.001) was higher in transplant patients.

Conclusion NIRS-IVUS imaging demonstrated early and accelerated lipid accumulation with smaller plaque burden and less calcium in patients after heart transplant when compared with patients with native atherosclerosis.

语种: 英语
项目资助者: Boston Scientific ; Volcano Corporation ; St Jude Medical ; InfraReDx
WOS记录号: WOS:000364539700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55332
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Columbia Univ, Med Ctr, NewYork Presbyterian, New York, NY 10027 USA
2.Cardiovasc Res Fdn, New York, NY USA
3.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
4.Icahn Sch Med Mt Sinai, New York, NY 10029 USA
5.Shaare Zedek Med Ctr, Dept Cardiol, IL-91031 Jerusalem, Israel

Recommended Citation:
Zheng, Bo,Maehara, Akiko,Mintz, Gary S.,et al. In vivo comparison between cardiac allograft vasculopathy and native atherosclerosis using near-infrared spectroscopy and intravascular ultrasound[J]. EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING,2015,16(9):985-991.
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