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Prevalence and prognostic significance of c-KIT mutations in core binding factor acute myeloid leukemia: A comprehensive large-scale study from a single Chinese center
Qin, Ya-Zhen1; Zhu, Hong-Hu1; Jiang, Qian1; Jiang, Hao1; Zhang, Le-Ping2; Xu, Lan-Ping1; Wang, Yu1; Liu, Yan-Rong1; Lai, Yue-Yun1; Shi, Hong-Xia1; Jiang, Bin1; Huang, Xiao-Jun1,3
关键词C-kit Mutations Core Binding Factor Acute Myeloid Leukemia t(8 21) Inv(16) Prognosis
刊名LEUKEMIA RESEARCH
2014-12-01
DOI10.1016/j.leukres.2014.09.017
38期:12页:1435-1440
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]MINIMAL RESIDUAL DISEASE ; INTERNAL TANDEM DUPLICATION ; POLYMERASE-CHAIN-REACTION ; COOPERATIVE-STUDY-GROUP ; BLOOD-CELL INDEX ; GROUP-B ; ACTIVATING MUTATIONS ; CANCER PROGRAM ; GENE-MUTATIONS ; RQ-PCR
英文摘要

To clarify the prevalence and prognostic significance of c-KIT mutations in patients with core binding factor acute myeloid leukemia (CBF-AML), a total of 351 patients who were categorized as pediatric t(8; 21), adult t(8; 21), pediatric inv(16), or adult inv(16) were screened at diagnosis for c-KIT mutations in exons 17 and 8 using direct sequencing. A total of 250 patients underwent follow-up. Overall, 36.5% of the patients had a c-KIT mutation. Adult t(8; 21) and inv(16) patients had mutations predominantly in exons 17 and 8, respectively. Higher White blood cell (WBC) count, WBC index, and AML1-ETO transcript levels in adult t(8; 21) patients were significantly associated with c-KIT mutations and mutations in exon 17 (P <= 0.030). c-KIT mutations in adult t(8; 21) patients were significantly correlated with a high cumulative incidence of relapse (CIR, P = 0.0070) at 2 years and a low 2-year disease-free survival (DFS, P = 0.013) and overall survival (OS, P = 0.0055). However, no significant difference was revealed in the effect of c-KIT mutations on outcome of adult inv(16) and pediatric t(8; 21) patients (all P > 0.05). Multivariate analysis revealed that c-KIT mutation is an independent prognostic factor for relapse, DFS, and OS (P <= 0.016) in adult t(8; 21) AML patients. Therefore, with regard to c-KIT mutation, CBF-AML is a heterogeneous disease. c-KIT mutations have a strong adverse effect on the relapse and survival of adult t(8; 21) AML patients. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000345614400010
项目编号81170483 ; 81370639 ; Z141100000214011
资助机构Nature Science Foundation of China ; Beijing Municipal Science and Technology Program
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55333
专题北京大学第二临床医学院_血液科
作者单位1.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Pediat, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Qin, Ya-Zhen,Zhu, Hong-Hu,Jiang, Qian,et al. Prevalence and prognostic significance of c-KIT mutations in core binding factor acute myeloid leukemia: A comprehensive large-scale study from a single Chinese center[J]. LEUKEMIA RESEARCH,2014,38(12):1435-1440.
APA Qin, Ya-Zhen.,Zhu, Hong-Hu.,Jiang, Qian.,Jiang, Hao.,Zhang, Le-Ping.,...&Huang, Xiao-Jun.(2014).Prevalence and prognostic significance of c-KIT mutations in core binding factor acute myeloid leukemia: A comprehensive large-scale study from a single Chinese center.LEUKEMIA RESEARCH,38(12),1435-1440.
MLA Qin, Ya-Zhen,et al."Prevalence and prognostic significance of c-KIT mutations in core binding factor acute myeloid leukemia: A comprehensive large-scale study from a single Chinese center".LEUKEMIA RESEARCH 38.12(2014):1435-1440.
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