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Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report
Gu, Feng1; Ma, Yongjie2; Fan, Yu1; Lang, Ronggang1; Ding, Ting1; Ha, Xishan1; Gong, Yun3; Kobayahsi, Hisayuki4; Fang, Zhiwei5; Fu, Li1
关键词Synovial Sarcoma Collagen Gel Droplet Embedded Culture-drug Sensitivity Test Neoadjuvant Chemotherapy
刊名ONCOLOGY LETTERS
2010-09-01
DOI10.3892/ol_00000157
1期:5页:885-888
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]IN-VITRO CHEMOSENSITIVITY ; SOFT-TISSUE SARCOMA ; CANCER
英文摘要

The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28-year old man presented at our hospital with a large mass in his right shank which had a hard texture and an obscure boundary. The histopathological diagnosis of excisional biopsy specimens was synovial sarcoma with low differentiation. Theprubicin/Cisplatin (THP/CDDP) neoadjuvant chemotherapy was selected based on the results obtained from the CD-DST. After three courses, a computed tomography (CT) scan was performed which indicated that the volume of the tumor had decreased significantly. Additionally, tumor necrosis, as well as the clinical response, showed complete response. The histopathological diagnosis of wide excision specimens indicated a grade III chemotherapy response. The patient was alive and without recurrence after a follow-up of 16 months. Our results indicated that the CD-DST is a useful tool for selecting neoadjuvant chemotherapeutic drugs for patients with synovial sarcoma.

语种英语
WOS记录号WOS:000284800500022
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55336
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_骨与软组织肿瘤科
作者单位1.Nitta Gelatin Inc, Osaka, Japan
2.Minist Educ, Antitumor Drug Sensit Test Lab, Dept Breast Canc Pathol & Res Lab, Key Lab Breast Canc Prevent & Therapy,Key Lab Can, Tianjin, Peoples R China
3.Tianjin Med Univ, Cent Lab Oncol Dept, Canc Hosp, Tianjin 300060, Peoples R China
4.Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
5.Peking Univ, Dept Orthoped Oncol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
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GB/T 7714
Gu, Feng,Ma, Yongjie,Fan, Yu,et al. Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report[J]. ONCOLOGY LETTERS,2010,1(5):885-888.
APA Gu, Feng.,Ma, Yongjie.,Fan, Yu.,Lang, Ronggang.,Ding, Ting.,...&Fu, Li.(2010).Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report.ONCOLOGY LETTERS,1(5),885-888.
MLA Gu, Feng,et al."Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report".ONCOLOGY LETTERS 1.5(2010):885-888.
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