IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report
Gu, Feng1; Ma, Yongjie2; Fan, Yu1; Lang, Ronggang1; Ding, Ting1; Ha, Xishan1; Gong, Yun3; Kobayahsi, Hisayuki4; Fang, Zhiwei5; Fu, Li1
关键词Synovial Sarcoma Collagen Gel Droplet Embedded Culture-drug Sensitivity Test Neoadjuvant Chemotherapy
刊名ONCOLOGY LETTERS
2010-09-01
DOI10.3892/ol_00000157
1期:5页:885-888
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]IN-VITRO CHEMOSENSITIVITY ; SOFT-TISSUE SARCOMA ; CANCER
英文摘要

The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28-year old man presented at our hospital with a large mass in his right shank which had a hard texture and an obscure boundary. The histopathological diagnosis of excisional biopsy specimens was synovial sarcoma with low differentiation. Theprubicin/Cisplatin (THP/CDDP) neoadjuvant chemotherapy was selected based on the results obtained from the CD-DST. After three courses, a computed tomography (CT) scan was performed which indicated that the volume of the tumor had decreased significantly. Additionally, tumor necrosis, as well as the clinical response, showed complete response. The histopathological diagnosis of wide excision specimens indicated a grade III chemotherapy response. The patient was alive and without recurrence after a follow-up of 16 months. Our results indicated that the CD-DST is a useful tool for selecting neoadjuvant chemotherapeutic drugs for patients with synovial sarcoma.

语种英语
WOS记录号WOS:000284800500022
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55336
Collection北京大学临床肿瘤学院
作者单位1.Nitta Gelatin Inc, Osaka, Japan
2.Minist Educ, Antitumor Drug Sensit Test Lab, Dept Breast Canc Pathol & Res Lab, Key Lab Breast Canc Prevent & Therapy,Key Lab Can, Tianjin, Peoples R China
3.Tianjin Med Univ, Cent Lab Oncol Dept, Canc Hosp, Tianjin 300060, Peoples R China
4.Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
5.Peking Univ, Dept Orthoped Oncol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
Recommended Citation
GB/T 7714
Gu, Feng,Ma, Yongjie,Fan, Yu,et al. Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report[J]. ONCOLOGY LETTERS,2010,1(5):885-888.
APA Gu, Feng.,Ma, Yongjie.,Fan, Yu.,Lang, Ronggang.,Ding, Ting.,...&Fu, Li.(2010).Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report.ONCOLOGY LETTERS,1(5),885-888.
MLA Gu, Feng,et al."Synovial sarcoma individual chemotherapy directed by collagen gel droplet embedded culture drug sensitivity test: A case report".ONCOLOGY LETTERS 1.5(2010):885-888.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Gu, Feng]'s Articles
[Ma, Yongjie]'s Articles
[Fan, Yu]'s Articles
百度学术
百度学术Similar articles in
[Gu, Feng]'s Articles
[Ma, Yongjie]'s Articles
[Fan, Yu]'s Articles
必应学术
必应学术Similar articles in
[Gu, Feng]'s Articles
[Ma, Yongjie]'s Articles
[Fan, Yu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.