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学科主题: 临床医学
题名:
Epidemiological characteristics of motor neuron disease in Chinese patients
作者: Cui, F.1; Liu, M.2; Chen, Y.3; Huang, X.1; Cui, L.2; Fan, D.4; Pu, C.1; Lu, J.3; Zhou, D.5; Zhang, C.6; Yan, C.7; Li, C.8; Ding, X.9; Liu, Y.10; Li, X.2; Jiang, Y.3; Zhang, J.4; Shang, H.5; Yao, X.6; Ding, Y.7; Niu, Q.9; Wang, L.4
关键词: amyotrophic lateral sclerosis ; epidemiology ; motor neuron disease ; nervous system disease ; Riluzole
刊名: ACTA NEUROLOGICA SCANDINAVICA
发表日期: 2014-08-01
DOI: 10.1111/ane.12240
卷: 130, 期:2, 页:111-117
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: AMYOTROPHIC-LATERAL-SCLEROSIS ; RISK-FACTOR ; CRITERIA ; ONSET ; NEUROPATHOLOGY ; DIAGNOSIS ; MEDICINE ; GENETICS ; HISTORY ; TRAUMA
英文摘要:

Background - The epidemiology, diagnosis, and treatment of motor neuron disease (MND) in Chinese patients are ill known.

Methods - A registered study of 461 MND patients was conducted across 10 facilities in 7 Chinese cities from February 2009 to March 2010.

Results - Patients were classified as amyotrophic lateral sclerosis (ALS) (84.4%), progressive bulbar palsy (PBP) (4.1%), progressive muscular atrophy (PMA) (10.4%), or primary lateral sclerosis (PLS) (0.9%). MND was predominant in men (men/women; 1.6: 1.0). Mean onset age was 52.6 years, with the highest incidence being observed between 51 and 60 years. Notably, 26.0% of MND patients were employed in forestry, fishery, or animal husbandry industries. Ten cases (2.7%) reported family history of MND, and 54.2% exhibited cervical onset. MND was also associated with head/neck trauma. Non-invasive positive pressure ventilation was the most common supportive therapy.

Conclusion - As a novel comprehensive report of a Chinese population, this study reveals that epidemiological characteristics of MND patients were similar to those observed in international populations. MND is age-related, male gender predominant, and may be associated with both environmental and genetic risk factors.

语种: 英语
所属项目编号: 2012FC-TSYS-4012
项目资助者: PLA General Hospital
WOS记录号: WOS:000339951900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55345
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

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作者单位: 1.Chinese Peoples Liberat Army Gen Hosp, Dept Neurol, Beijing, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Neurol, Beijing 100730, Peoples R China
3.Fudan Univ, Huashan Hosp, Dept Neurol, Shanghai 200433, Peoples R China
4.Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China
5.Sichuan Univ, West China Hosp, Dept Neurol, Chengdu 610064, Peoples R China
6.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou 510275, Guangdong, Peoples R China
7.Shandong Univ, Qilu Hosp, Dept Neurol, Jinan 250100, Peoples R China
8.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China
9.Jiangsu Prov Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China
10.Hebei Med Univ, Hosp 2, Dept Neurol, Shi Jiangzhuang, Peoples R China

Recommended Citation:
Cui, F.,Liu, M.,Chen, Y.,et al. Epidemiological characteristics of motor neuron disease in Chinese patients[J]. ACTA NEUROLOGICA SCANDINAVICA,2014,130(2):111-117.
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