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学科主题: 临床医学
题名:
Gestational diabetes mellitus, programing and epigenetics
作者: Yan, Jie; Yang, Huixia
关键词: DNA methylation ; epigenetics ; gestational diabetes mellitus ; intrauterine environment ; programing
刊名: JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
发表日期: 2014-08-01
DOI: 10.3109/14767058.2013.853733
卷: 27, 期:12, 页:1266-1269
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: INTRAUTERINE GROWTH-RETARDATION ; REMODELS PROMOTER METHYLATION ; NON-CPG METHYLATION ; MISSING HERITABILITY ; PRENATAL EXPOSURE ; FAMINE ; PREGNANCY ; DISEASE ; GLUCOSE ; OBESITY
英文摘要:

Gestational diabetes mellitus (GDM) is a common medical complication in pregnancy. Offspring exposed to maternal hyperglycemia have a higher birth weight and are prone to develop metabolic disease in adult life. The intrauterine environmental or nutritional status seems to be involved in the fetal programing. The concept of "Developmental Origins of Health and Disease′′ (DOHaD) has been widely accepted and it brings new insights into the molecular pathogenesis of human diseases. The underlying mechanism is still under discussion and epigenetic mechanisms may provide an explanation for the phenomenon. The aim of this review is to illustrate the role of epigenetic modifications in the development of insulin resistance in metabolic diseases induced by adverse intrauterine exposures. Changes in epigenetic mechanism may be an early event in pathogenesis and progression of the metabolic disease in humans. Studies on epigenetic modifications contribute to our understanding of long-term effects of in utero exposure and shed light on the disease prevention and treatment by modulating epigenetic changes.

语种: 英语
WOS记录号: WOS:000339563100017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55351
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China

Recommended Citation:
Yan, Jie,Yang, Huixia. Gestational diabetes mellitus, programing and epigenetics[J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE,2014,27(12):1266-1269.
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