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学科主题临床医学
Gestational diabetes mellitus, programing and epigenetics
Yan, Jie; Yang, Huixia
关键词Dna Methylation Epigenetics Gestational Diabetes Mellitus Intrauterine Environment Programing
刊名JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
2014-08-01
DOI10.3109/14767058.2013.853733
27期:12页:1266-1269
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]INTRAUTERINE GROWTH-RETARDATION ; REMODELS PROMOTER METHYLATION ; NON-CPG METHYLATION ; MISSING HERITABILITY ; PRENATAL EXPOSURE ; FAMINE ; PREGNANCY ; DISEASE ; GLUCOSE ; OBESITY
英文摘要

Gestational diabetes mellitus (GDM) is a common medical complication in pregnancy. Offspring exposed to maternal hyperglycemia have a higher birth weight and are prone to develop metabolic disease in adult life. The intrauterine environmental or nutritional status seems to be involved in the fetal programing. The concept of "Developmental Origins of Health and Disease′′ (DOHaD) has been widely accepted and it brings new insights into the molecular pathogenesis of human diseases. The underlying mechanism is still under discussion and epigenetic mechanisms may provide an explanation for the phenomenon. The aim of this review is to illustrate the role of epigenetic modifications in the development of insulin resistance in metabolic diseases induced by adverse intrauterine exposures. Changes in epigenetic mechanism may be an early event in pathogenesis and progression of the metabolic disease in humans. Studies on epigenetic modifications contribute to our understanding of long-term effects of in utero exposure and shed light on the disease prevention and treatment by modulating epigenetic changes.

语种英语
WOS记录号WOS:000339563100017
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55351
专题北京大学第一临床医学院
北京大学第一临床医学院_妇产科
北京大学第三临床医学院_妇产科
作者单位Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yan, Jie,Yang, Huixia. Gestational diabetes mellitus, programing and epigenetics[J]. JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE,2014,27(12):1266-1269.
APA Yan, Jie,&Yang, Huixia.(2014).Gestational diabetes mellitus, programing and epigenetics.JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE,27(12),1266-1269.
MLA Yan, Jie,et al."Gestational diabetes mellitus, programing and epigenetics".JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE 27.12(2014):1266-1269.
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