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学科主题: 临床医学
题名:
Prevalence of minimal hepatic encephalopathy and quality of life evaluations in hospitalized cirrhotic patients in China
作者: Wang, Ji-Yao1; Zhang, Ning-Ping1; Chi, Bao-Rong2; Mi, Yu-Qing3; Meng, Li-Na4; Liu, Ying-Di5; Wang, Jiang-Bin6; Jiang, Hai-Xing7; Yang, Jin-Hui8; Xu, Yun9; Li, Xiao10; Xu, Jian-Ming11; Zhang, Guo12; Zhou, Xin-Min13; Zhuge, Yu-Zheng14; Tian, De-An15; Ye, Jin16; Liu, Yu-Lan17
关键词: Minimal hepatic encephalopathy ; Health-related quality of life ; China ; Child-Pugh Classification ; Liver cirrhosis
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2013-08-14
DOI: 10.3748/wjg.v19.i30.4984
卷: 19, 期:30, 页:4984-4991
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: CONSENSUS STATEMENT ; LIVER-CIRRHOSIS ; WORKING PARTY ; DIAGNOSIS ; AGREEMENT ; LACTULOSE ; KAPPA ; TESTS
英文摘要:

AIM: To investigate the prevalence of minimal hepatic encephalopathy (MHE) and to assess corresponding health-related quality of life (HRQoL) in hospitalized cirrhotic patients in China.

METHODS: This multi-center cross-sectional study included 16 teaching hospitals, which were members of "Hepatobiliary Cooperation Group, Society of Gastroenterology, Chinese Medical Association", from different areas of China carried out between June and October in 2011. All the eligible hospitalized cirrhotic patients (n = 538) were required to complete triplicate number connection tests combined with one digit symbol test for diagnosing MHE. Patients′ clinical examination data were complemented by a modified questionnaire assessing HRQoL. Written informed consent was obtained from each patient.

RESULTS: Male was predominant (68.6%) in 519 patients who met the criteria of the study, with a mean age of 49.17 +/- 11.02 years. The most common cause of liver cirrhosis was chronic hepatitis B (55.9%). The prevalence of MHE was 39.9% and varied by Child-Pugh-Classification score (CPC-A: 24.8%, CPC-B: 39.4% and CPC-C: 56.1%, P < 0.01). MHE (P < 0.01) and higher CPC scores (P < 0.01) were associated with a high HRQoL scores (reflecting poorer quality of life). The prevalence of MHE was proportionate to CPC (P = 0.01) and high quality of life scores (P = 0.01).

CONCLUSION: Hospitalized cirrhotic patients have a high prevalence of MHE that is proportionate to the degree of liver function and HRQoL impairment. (C) 2013 Baishideng. All rights reserved.

语种: 英语
WOS记录号: WOS:000323326700018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55355
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Fudan Univ, Ctr Clin Epidemiol & Evidence Based Med, Dept Gastroenterol & Hepatol, Zhongshan Hosp, Shanghai 200032, Peoples R China
2.Jilin Univ, Hosp 1, Dept Digest Dis, Changchun 130021, Peoples R China
3.Tianjin Infect Dis Hosp, Dept Hepatol, Tianjin 300192, Peoples R China
4.Zhejiang Prov Hosp Tradit Chinese Med, Dept Digest Dis, Hangzhou 310006, Zhejiang, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Hosp 301, Dept Digest Dis, Beijing 100853, Peoples R China
6.Jilin Univ, China Japan Union Hosp, Dept Digest Dis, Changchun 130031, Jilin, Peoples R China
7.Guangxi Med Univ, Affiliated Hosp 1, Dept Digest Dis, Nanning 530021, Guangxi Zhuang, Peoples R China
8.Kunming Med Univ, Dept Hepatol, Affiliated Hosp 2, Kunming 650101, Yunnan Province, Peoples R China
9.Zhengzhou Univ, Affiliated Hosp 1, Dept Digest Dis, Zhengzhou 450052, Henan, Peoples R China
10.Sichuan Univ, Dept Digest Dis, West China Hosp, Chengdu 610041, Sichuan Provinc, Peoples R China
11.Anhui Med Univ, Dept Digest Dis, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China
12.Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Digest Dis, Nanning 530021, Guangxi Zhuang, Peoples R China
13.Fourth Mil Med Univ, Xijing Hosp, Dept Digest Dis, Xian 230022, Peoples R China
14.Nanjing Univ, Sch Med, Dept Digest Dis, Nanjing Drum Tower Hosp, Nanjing 210008, Jiangsu, Peoples R China
15.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
16.Huazhong Univ Sci & Technol, Dept Gastroenterol, Union Hosp, Tongji Med Coll, Wuhan 430022, Hunan, Peoples R China
17.Peking Univ, Peoples Hosp, Dept Digest Dis, Beijing 100044, Peoples R China

Recommended Citation:
Wang, Ji-Yao,Zhang, Ning-Ping,Chi, Bao-Rong,et al. Prevalence of minimal hepatic encephalopathy and quality of life evaluations in hospitalized cirrhotic patients in China[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2013,19(30):4984-4991.
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