IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Prevalence of minimal hepatic encephalopathy and quality of life evaluations in hospitalized cirrhotic patients in China
Wang, Ji-Yao1; Zhang, Ning-Ping1; Chi, Bao-Rong2; Mi, Yu-Qing3; Meng, Li-Na4; Liu, Ying-Di5; Wang, Jiang-Bin6; Jiang, Hai-Xing7; Yang, Jin-Hui8; Xu, Yun9; Li, Xiao10; Xu, Jian-Ming11; Zhang, Guo12; Zhou, Xin-Min13; Zhuge, Yu-Zheng14; Tian, De-An15; Ye, Jin16; Liu, Yu-Lan17
关键词Minimal Hepatic Encephalopathy Health-related Quality Of Life China Child-pugh Classification Liver Cirrhosis
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2013-08-14
DOI10.3748/wjg.v19.i30.4984
19期:30页:4984-4991
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]CONSENSUS STATEMENT ; LIVER-CIRRHOSIS ; WORKING PARTY ; DIAGNOSIS ; AGREEMENT ; LACTULOSE ; KAPPA ; TESTS
英文摘要

AIM: To investigate the prevalence of minimal hepatic encephalopathy (MHE) and to assess corresponding health-related quality of life (HRQoL) in hospitalized cirrhotic patients in China.

METHODS: This multi-center cross-sectional study included 16 teaching hospitals, which were members of "Hepatobiliary Cooperation Group, Society of Gastroenterology, Chinese Medical Association", from different areas of China carried out between June and October in 2011. All the eligible hospitalized cirrhotic patients (n = 538) were required to complete triplicate number connection tests combined with one digit symbol test for diagnosing MHE. Patients′ clinical examination data were complemented by a modified questionnaire assessing HRQoL. Written informed consent was obtained from each patient.

RESULTS: Male was predominant (68.6%) in 519 patients who met the criteria of the study, with a mean age of 49.17 +/- 11.02 years. The most common cause of liver cirrhosis was chronic hepatitis B (55.9%). The prevalence of MHE was 39.9% and varied by Child-Pugh-Classification score (CPC-A: 24.8%, CPC-B: 39.4% and CPC-C: 56.1%, P < 0.01). MHE (P < 0.01) and higher CPC scores (P < 0.01) were associated with a high HRQoL scores (reflecting poorer quality of life). The prevalence of MHE was proportionate to CPC (P = 0.01) and high quality of life scores (P = 0.01).

CONCLUSION: Hospitalized cirrhotic patients have a high prevalence of MHE that is proportionate to the degree of liver function and HRQoL impairment. (C) 2013 Baishideng. All rights reserved.

语种英语
WOS记录号WOS:000323326700018
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55355
专题北京大学第二临床医学院
北京大学第二临床医学院_消化科
作者单位1.Fudan Univ, Ctr Clin Epidemiol & Evidence Based Med, Dept Gastroenterol & Hepatol, Zhongshan Hosp, Shanghai 200032, Peoples R China
2.Jilin Univ, Hosp 1, Dept Digest Dis, Changchun 130021, Peoples R China
3.Tianjin Infect Dis Hosp, Dept Hepatol, Tianjin 300192, Peoples R China
4.Zhejiang Prov Hosp Tradit Chinese Med, Dept Digest Dis, Hangzhou 310006, Zhejiang, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Hosp 301, Dept Digest Dis, Beijing 100853, Peoples R China
6.Jilin Univ, China Japan Union Hosp, Dept Digest Dis, Changchun 130031, Jilin, Peoples R China
7.Guangxi Med Univ, Affiliated Hosp 1, Dept Digest Dis, Nanning 530021, Guangxi Zhuang, Peoples R China
8.Kunming Med Univ, Dept Hepatol, Affiliated Hosp 2, Kunming 650101, Yunnan Province, Peoples R China
9.Zhengzhou Univ, Affiliated Hosp 1, Dept Digest Dis, Zhengzhou 450052, Henan, Peoples R China
10.Sichuan Univ, Dept Digest Dis, West China Hosp, Chengdu 610041, Sichuan Provinc, Peoples R China
11.Anhui Med Univ, Dept Digest Dis, Affiliated Hosp 1, Hefei 230022, Anhui, Peoples R China
12.Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Digest Dis, Nanning 530021, Guangxi Zhuang, Peoples R China
13.Fourth Mil Med Univ, Xijing Hosp, Dept Digest Dis, Xian 230022, Peoples R China
14.Nanjing Univ, Sch Med, Dept Digest Dis, Nanjing Drum Tower Hosp, Nanjing 210008, Jiangsu, Peoples R China
15.Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
16.Huazhong Univ Sci & Technol, Dept Gastroenterol, Union Hosp, Tongji Med Coll, Wuhan 430022, Hunan, Peoples R China
17.Peking Univ, Peoples Hosp, Dept Digest Dis, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wang, Ji-Yao,Zhang, Ning-Ping,Chi, Bao-Rong,et al. Prevalence of minimal hepatic encephalopathy and quality of life evaluations in hospitalized cirrhotic patients in China[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2013,19(30):4984-4991.
APA Wang, Ji-Yao.,Zhang, Ning-Ping.,Chi, Bao-Rong.,Mi, Yu-Qing.,Meng, Li-Na.,...&Liu, Yu-Lan.(2013).Prevalence of minimal hepatic encephalopathy and quality of life evaluations in hospitalized cirrhotic patients in China.WORLD JOURNAL OF GASTROENTEROLOGY,19(30),4984-4991.
MLA Wang, Ji-Yao,et al."Prevalence of minimal hepatic encephalopathy and quality of life evaluations in hospitalized cirrhotic patients in China".WORLD JOURNAL OF GASTROENTEROLOGY 19.30(2013):4984-4991.
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