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学科主题临床医学
Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage
Cheng, AX; Lou, SQ; Zhou, HW; Wang, Y; Ma, DL
关键词Apoptosis Cartilage Osteoarthritis Pdcd5
刊名ACTA PHARMACOLOGICA SINICA
2004-05-01
25期:5页:685-690
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]HUMAN ARTICULAR-CARTILAGE ; CHONDROCYTES ; TFAR19 ; CELLS
英文摘要

AIM: To investigate the expression features of PDCD5 (programmed cell death 5 protein) in osteoarthritic and normal human cartilage, and speculate on its potential functions in the pathogenesis of osteoarthritis (OA). METHODS: Articular cartilage specimens were obtained from 30 patients with OA and 16 healthy patients at the time of arthroplasty. Expression of PDCD5 was detected by flow cytometry, immunofluorescence, RT-PCR and immunohistochemical analysis. RESULTS: Enhanced expression and nuclear accumulation of PDCD5 in OA chondrocytes were found. PDCD5-positive chondrocytes were mainly distributed in the superficial and deep zones of OA tissue sections, as opposed to, in the superficial and middle regions of normal healthy tissue sections. CONCLUSION: Since apoptotic chondrocyte death occurs more frequently in OA cartilage than in normal healthy cartilage and PDCD5 is an apoptosis-related protein, the different expression patterns of PDCD5 in OA cartilage from that in normal healthy cartilage indicate that PDCD5 is involved in the pathogenesis of OA.

语种英语
WOS记录号WOS:000221337100023
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55356
专题北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Hosp 3, Dept Orthopaed Surg, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
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Cheng, AX,Lou, SQ,Zhou, HW,et al. Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage[J]. ACTA PHARMACOLOGICA SINICA,2004,25(5):685-690.
APA Cheng, AX,Lou, SQ,Zhou, HW,Wang, Y,&Ma, DL.(2004).Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage.ACTA PHARMACOLOGICA SINICA,25(5),685-690.
MLA Cheng, AX,et al."Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage".ACTA PHARMACOLOGICA SINICA 25.5(2004):685-690.
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