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学科主题: 临床医学
题名:
Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage
作者: Cheng, AX; Lou, SQ; Zhou, HW; Wang, Y; Ma, DL
关键词: apoptosis ; cartilage ; osteoarthritis ; PDCD5
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2004-05-01
卷: 25, 期:5, 页:685-690
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: HUMAN ARTICULAR-CARTILAGE ; CHONDROCYTES ; TFAR19 ; CELLS
英文摘要:

AIM: To investigate the expression features of PDCD5 (programmed cell death 5 protein) in osteoarthritic and normal human cartilage, and speculate on its potential functions in the pathogenesis of osteoarthritis (OA). METHODS: Articular cartilage specimens were obtained from 30 patients with OA and 16 healthy patients at the time of arthroplasty. Expression of PDCD5 was detected by flow cytometry, immunofluorescence, RT-PCR and immunohistochemical analysis. RESULTS: Enhanced expression and nuclear accumulation of PDCD5 in OA chondrocytes were found. PDCD5-positive chondrocytes were mainly distributed in the superficial and deep zones of OA tissue sections, as opposed to, in the superficial and middle regions of normal healthy tissue sections. CONCLUSION: Since apoptotic chondrocyte death occurs more frequently in OA cartilage than in normal healthy cartilage and PDCD5 is an apoptosis-related protein, the different expression patterns of PDCD5 in OA cartilage from that in normal healthy cartilage indicate that PDCD5 is involved in the pathogenesis of OA.

语种: 英语
WOS记录号: WOS:000221337100023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55356
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Orthopaed Surg, Beijing 100083, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China

Recommended Citation:
Cheng, AX,Lou, SQ,Zhou, HW,et al. Expression of PDCD5, a novel apoptosis related protein, in human osteoarthritic cartilage[J]. ACTA PHARMACOLOGICA SINICA,2004,25(5):685-690.
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