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Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries
Conway, David I.1; Brenner, Darren R.2; McMahon, Alex D.1; Macpherson, Lorna M. D.1; Agudo, Antonio3; Ahrens, Wolfgang4,5; Bosetti, Cristina6; Brenner, Hermann7; Castellsague, Xavier8; Chen, Chu9; Curado, Maria Paula10; Curioni, Otavio A.11; Dal Maso, Luigino12; Daudt, Alexander W.13; de Gois Filho, Jose F.14; D′ Souza, Gypsyamber15; Edefonti, Valeria16; Fabianova, Eleonora17; Fernandez, Leticia18; Franceschi, Silvia2; Gillison, Maura19; Hayes, Richard B.20; Healy, Claire M.21; Herrero, Rolando22; Holcatova, Ivana23; Jayaprakash, Vijayvel24; Kelsey, Karl25; Kjaerheim, Kristina26; Koifman, Sergio27; La Vecchia, Carlo6; Lagiou, Pagona28; Lazarus, Philip29; Levi, Fabio30,62; Lissowska, Jolanta31,63; Luce, Daniele32; Macfarlane, Tatiana V.33; Mates, Dana34; Matos, Elena35; McClean, Michael36; Menezes, Ana M.37; Menvielle, Gwenn32; Merletti, Franco38; Morgenstern, Hal39,64,65; Moysich, Kirsten24; Mueller, Heiko6; Muscat, Joshua40; Olshan, Andrew F.41; Purdue, Mark P.42; Ramroth, Heribert43; Richiardi, Lorenzo38; Rudnai, Peter44; Schantz, Stimson45; Schwartz, Stephen M.9; Shangina, Oxana46; Simonato, Lorenzo47; Smith, Elaine48; Stucker, Isabelle32; Sturgis, Erich M.49; Szeszenia-Dabrowska, Neonila50; Talamini, Renato12; Thomson, Peter51; Vaughan, Thomas L.9; Wei, Qingyi49; Winn, Deborah M.52; Wunsch-Filho, Victor53; Yu, Guo-Pei54,55; Zhang, Zuo-Feng56; Zheng, Tongzhang57; Znaor, Ariana58; Boffetta, Paolo10,59; Chuang, Shu-Chun60; Ghodrat, Marianoosh61; Lee, Yuan-Chin Amy61; Hashibe, Mia61; Brennan, Paul2
关键词Head And Neck Cancer Socioeconomic Inequalities Epidemiology
收录类别SCI ; SSCI
WOS标题词Science & Technology

Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 - 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 - 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.

What′s new? Head and neck cancer is among the most common and increasing cancers in the world. Besides smoking, alcohol drinking, and human papilloma virus infections, low socioeconomic status has been implicated as one of the most important risk factors for this cancer type. This large multinational study authoritatively confirmed that lower education status and lower income are associated with increased risk for head and neck cancer development. Smoking and alcohol consumption could not entirely explain the risk associated with low socioeconomic factors, and therefore, as the authors argue, need to be more explicitly recognized in the etiology associated with head and neck cancer.

项目编号R03CA113157 ; R03DE016611 ; 10068 ; PRIN 2009 X8YCBN
资助机构UICC Yamagiwa-Yoshida Memorial International Cancer Study ; International Agency for Research on Cancer, Lyon, France Visiting Scientist Award ; INHANCE Pooled Data Coordination ; NCI ; NIDCR ; Italian Association for Research on Cancer (AIRC) ; Italian Ministry of Research ; Swiss League against Cancer ; Swiss Research against Cancer/Oncosuisse, Switzerland
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
作者单位1.Int Agcy Res Canc, F-69372 Lyon, France
2.Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA
3.BIPS Inst Epidemiol & Prevent Res, Bremen, Germany
4.Univ Bremen, Inst Stat, D-28359 Bremen, Germany
5.German Canc Res Ctr, Heidelberg, Germany
6.ICO, IDIBELL, CIBER ESP, Barcelona, Catalonia, Spain
7.Inst Occupat Med, Lodz, Poland
8.NCI, NIH, Bethesda, MD 20892 USA
9.New York Med Coll, Valhalla, NY 10595 USA
10.Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA
11.Peking Univ, Med Informat Ctr, Beijing 100871, Peoples R China
12.Int Prevent Res Inst, Lyon, France
13.Hosp Heliopolis, Sao Paulo, Brazil
14.Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil
15.Inst Canc Arnaldo Viera de Carvalho, Sao Paulo, Brazil
16.Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA
17.Yale Univ, New Heaven, CT USA
18.Mt Sinai Sch Med, Tisch Canc Inst, New York, NY USA
19.Univ Utah, Sch Med, Salt Lake City, UT USA
20.Univ Lausanne, Lausanne, Switzerland
21.Reg Author Publ Hlth, Banska Bystrica, Slovakia
22.Inst Oncol, Warsaw, Poland
23.Int Agcy Res Canc, Prevent & Implementat Grp, F-69372 Lyon, France
24.Univ Iowa, Coll Publ Hlth, Iowa City, IA 52242 USA
25.Inst Oncol & Radiobiol, Havana, Cuba
26.Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
27.NYU, Sch Med, Div Epidemiol, New York, NY 10003 USA
28.Univ Dublin Trinity Coll, Sch Dent Sci, Dublin 2, Ireland
29.Univ Glasgow, Glasgow Dent Sch, Coll Med Vet & Life Sci, Glasgow G2 3JZ, Lanark, Scotland
30.Catalan Inst Oncol ICO, Environm & Canc Epidemiol Res Program, Unit Nutr, Barcelona, Spain
31.IRCCS Ist Ric Farmacol Mario Negri, Dept Epidemiol, Milan, Italy
32.Ctr Riferimento Oncol IRCCS, Epidemiol & Biostat Unit, Aviano, Italy
33.Univ Milan, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy
34.Charles Univ Prague, Inst Hyg & Epidemiol, Fac Med 1, Prague, Czech Republic
35.Roswell Pk Canc Inst, Buffalo, NY 14263 USA
36.Brown Univ, Providence, RI 02912 USA
37.Canc Registry Norway, Oslo, Norway
38.Fundacao Oswaldo Cruz, Escola Nacl Saude Publ, Rio De Janeiro, Brazil
39.Univ Athens, Sch Med, GR-11527 Athens, Greece
40.Washington State Univ, Coll Pharm, Spokane, WA USA
41.CHU Vaudois, Inst Med Sociale & Prevent IUMSP, CH-1011 Lausanne, Switzerland
42.M Sklodowska Curie Mem Canc Ctr, Dept Canc Epidemiol & Prevent, Warsaw, Poland
43.INSERM, Ctr Res Epidemiol & Populat Hlth CESP, U1018, Villejuif, France
44.Univ Aberdeen, Sch Dent, Aberdeen, Scotland
45.Natl Inst Publ Hlth, Bucharest, Romania
46.Univ Buenos Aires, Inst Oncol Angel H Roffo, RA-1053 Buenos Aires, DF, Argentina
47.Boston Univ, Sch Publ Hlth, Boston, MA USA
48.Univ Fed Pelotas, Capao Do Leao, RS, Brazil
49.Univ Turin, Dept Med Sci, I-10124 Turin, Italy
50.Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA
51.NCI, Bethesda, MD 20892 USA
52.Natl Inst Environm Hlth, Budapest, Hungary
53.New York Eye & Ear Infirm, New York, NY USA
54.Russian Acad Med Sci, Canc Res Ctr, Moscow, Russia
55.Penn State Coll Med, Hershey, PA USA
56.Univ N Carolina, Gillings Sch Global Publ Hlth, Chapel Hill, NC USA
57.Heidelberg Univ, Inst Publ Hlth, D-69115 Heidelberg, Germany
58.Univ Padua, Dept Mol Med, Lab Publ Hlth & Populat Studies, I-35100 Padua, Italy
59.Newcastle Univ, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
60.Univ Sao Paulo, Fac Saude Publ, Dept Epidemiol, BR-05508 Sao Paulo, Brazil
61.Univ Calif Los Angeles, Sch Publ Hlth, Los Angeles, CA 90024 USA
62.Croatian Natl Inst Publ Hlth, Croatian Natl Canc Registry, Zagreb, Croatia
63.Natl Hlth Res Inst, Inst Populat Hlth Sci, Div Hlth Policy Translat, Miaoli, Taiwan
64.Univ Michigan, Sch Publ Hlth, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
65.Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI 48109 USA
GB/T 7714
Conway, David I.,Brenner, Darren R.,McMahon, Alex D.,et al. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries[J]. INTERNATIONAL JOURNAL OF CANCER,2015,136(5):1125-1139.
APA Conway, David I..,Brenner, Darren R..,McMahon, Alex D..,Macpherson, Lorna M. D..,Agudo, Antonio.,...&Brennan, Paul.(2015).Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries.INTERNATIONAL JOURNAL OF CANCER,136(5),1125-1139.
MLA Conway, David I.,et al."Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries".INTERNATIONAL JOURNAL OF CANCER 136.5(2015):1125-1139.
[Conway, David I.]的文章
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