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学科主题: 临床医学
题名:
Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats
作者: Zhang, Jing; Ren, Cai Xia; Qi, Yong Fen; Lou, Li Xia; Chen, Li; Zhang, Li Ke; Wang, Xian; Tang, Chaoshu
关键词: apelin ; APJ ; hypertension ; exercise training
刊名: LIFE SCIENCES
发表日期: 2006-08-15
DOI: 10.1016/j.lfs.2006.03.040
卷: 79, 期:12, 页:1153-1159
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: ORPHAN RECEPTOR APJ ; ENDOGENOUS PEPTIDE LIGAND ; MESSENGER-RNA EXPRESSION ; CARDIAC CONTRACTILITY ; BLOOD-PRESSURE ; HEART-FAILURE ; IN-VIVO ; GLUCOCORTICOIDS ; STRESS ; ACID
英文摘要:

Because apelin may play an important regulatory role in human cardiac dysfunction, we investigated alterations in cardiovascular content of apelin and its receptor, APJ, during hypertension and the effect of exercise training on the cardiovascular apelin/APJ system in hypertensive animals. Spontaneously hypertensive rats (SITRs) underwent swimming training consisting of 54 swimming sessions of 60 min each (6 days/week for 9 weeks). Systolic blood pressure (SBP) was verified weekly by tail-cuff plethysmography. Apelin levels in plasma and cardiovascular tissues were determined by radioimmunoassay. The level of apelin/APJ mRNA was determined by RT-PCR. SHRs showed severe hypertension and pathological cardiomegaly. The level of apelin immunoreactivity (apelin-ir) in plasma and ventricular and aortic tissues was lower, by 40%, 40% and 42% (all P < 0.01), respectively, in SHRs than in control Wistar-Kyoto rats, and the mRNA level of apelin and APJ in myocardium and aorta was markedly decreased. Compared with sedentary SHRs, swimming-trained SHRs showed decreased SBP and elevated mRNA expression of apelin and APJ in cardiovascular tissues and elevated apelin-ir level in plasma, myocardium and aorta (all P < 0.01). SBP and level of apelin-ir in plasma and cardiovascular tissues were negatively correlated. Long-term swimming training relieved the pathogenesis of hypertension and reversed the downregulation of the cardiovascular apelin/APJ system induced by hypertension, which suggests that the improving effect of exercise training on hypertension could be mediated by upregulating the cardiovascular apelin/APJ system. (c) 2006 Published by Elsevier Inc.

语种: 英语
WOS记录号: WOS:000239701200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55364
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Key Lab Minist Educ Mol Cardiol, Beijing 100083, Peoples R China
2.Peking Univ First Hosp, Inst Cardiovasc Res, Beijing 100034, Peoples R China
3.Yangzhou Univ, Phys Educ Coll, Yangzhou 225002, Jiangsu, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
5.Capital Univ Med, Dept Pathophysiol, Beijing 100054, Peoples R China

Recommended Citation:
Zhang, Jing,Ren, Cai Xia,Qi, Yong Fen,et al. Exercise training promotes expression of apelin and APJ of cardiovascular tissues in spontaneously hypertensive rats[J]. LIFE SCIENCES,2006,79(12):1153-1159.
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