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学科主题: 医学信息学
题名:
Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients
作者: Hou, L; Osei-Hyiaman, D; Yu, H; Ren, Z; Zhang, Z; Wang, B; Harada, S
刊名: NEUROLOGY
发表日期: 2001-02-27
卷: 56, 期:4, 页:490-496
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NITRIC-OXIDE-SYNTHASE ; ANGIOTENSIN-CONVERTING ENZYME ; CORONARY-ARTERY DISEASE ; HEART-DISEASE ; YOUNG-ADULTS ; RISK FACTOR ; MUTATION ; CLONING ; EXPRESSION ; TWINS
英文摘要:

Objective: To investigate the association between a 27-bp repeat polymorphism of the ecNOS gene in 364 patients with ischemic stroke and 516 control subjects. Background: The incidence of stroke in China is higher than that of coronary artery disease. Furthermore, ischemic stroke is more prevalent than hemorrhagic stroke. A 27-bp repeat polymorphism in intron 4 of the endothelial constitutive nitric oxide synthase (ecNOS) gene has been reported to associate with coronary artery disease in an Australian population, but no association was found between this polymorphism and ischemic stroke in a Japanese population. Methods: All patients and unrelated control subjects were screened by CT. All participants lived in central China. Multivariate logistic regression analysis was used to determine the independent roles of this ecNOS gene polymorphism and covariates in ischemic stroke. Results: These results indicated an association between the ecNOS a allele and ischemic stroke in the Chinese patients studied (7.8 versus 17.0%; OR = 2.44; 95% CI = 1.60 to 3.71,p < 0.0001). Conclusion: The ecNOS a allele in intron 4 may be an independent risk factor for ischemic stroke in the Chinese population studied, especially in those lacking other conventional risk factors.

语种: 英语
WOS记录号: WOS:000167154500014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55368
Appears in Collections:北京大学医学信息学中心_期刊论文

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作者单位: 1.Taiyuan City Hosp, Dept Internal Med, Taiyuan, Peoples R China
2.Shanxi Med Univ, Dept Epidemiol, Shanxi, Peoples R China
3.Beicheng Cent Hosp, Dept Internal Med, Taiyuan, Peoples R China
4.Univ Tsukuba, Grad Sch Med, Tsukuba, Ibaraki 3058575, Japan
5.Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 3058575, Japan
6.Beijing Med Univ, Med Informat Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Hou, L,Osei-Hyiaman, D,Yu, H,et al. Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients[J]. NEUROLOGY,2001,56(4):490-496.
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