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Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients
Hou, L; Osei-Hyiaman, D; Yu, H; Ren, Z; Zhang, Z; Wang, B; Harada, S
刊名NEUROLOGY
2001-02-27
56期:4页:490-496
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NITRIC-OXIDE-SYNTHASE ; ANGIOTENSIN-CONVERTING ENZYME ; CORONARY-ARTERY DISEASE ; HEART-DISEASE ; YOUNG-ADULTS ; RISK FACTOR ; MUTATION ; CLONING ; EXPRESSION ; TWINS
英文摘要

Objective: To investigate the association between a 27-bp repeat polymorphism of the ecNOS gene in 364 patients with ischemic stroke and 516 control subjects. Background: The incidence of stroke in China is higher than that of coronary artery disease. Furthermore, ischemic stroke is more prevalent than hemorrhagic stroke. A 27-bp repeat polymorphism in intron 4 of the endothelial constitutive nitric oxide synthase (ecNOS) gene has been reported to associate with coronary artery disease in an Australian population, but no association was found between this polymorphism and ischemic stroke in a Japanese population. Methods: All patients and unrelated control subjects were screened by CT. All participants lived in central China. Multivariate logistic regression analysis was used to determine the independent roles of this ecNOS gene polymorphism and covariates in ischemic stroke. Results: These results indicated an association between the ecNOS a allele and ischemic stroke in the Chinese patients studied (7.8 versus 17.0%; OR = 2.44; 95% CI = 1.60 to 3.71,p < 0.0001). Conclusion: The ecNOS a allele in intron 4 may be an independent risk factor for ischemic stroke in the Chinese population studied, especially in those lacking other conventional risk factors.

语种英语
WOS记录号WOS:000167154500014
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被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55368
专题北京大学医学信息学中心
作者单位1.Taiyuan City Hosp, Dept Internal Med, Taiyuan, Peoples R China
2.Shanxi Med Univ, Dept Epidemiol, Shanxi, Peoples R China
3.Beicheng Cent Hosp, Dept Internal Med, Taiyuan, Peoples R China
4.Univ Tsukuba, Grad Sch Med, Tsukuba, Ibaraki 3058575, Japan
5.Univ Tsukuba, Inst Community Med, Tsukuba, Ibaraki 3058575, Japan
6.Beijing Med Univ, Med Informat Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Hou, L,Osei-Hyiaman, D,Yu, H,et al. Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients[J]. NEUROLOGY,2001,56(4):490-496.
APA Hou, L.,Osei-Hyiaman, D.,Yu, H.,Ren, Z.,Zhang, Z.,...&Harada, S.(2001).Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients.NEUROLOGY,56(4),490-496.
MLA Hou, L,et al."Association of a 27-bp repeat polymorphism in ecNOS gene with ischemic stroke in Chinese patients".NEUROLOGY 56.4(2001):490-496.
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