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学科主题: 基础医学
题名:
Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat
作者: Fang, M; Wang, Y; Liu, HX; Liu, XS; Han, JS
关键词: arthritis ; chronic pain ; GDNF ; neurotrophin ; rat ; spinal cord
刊名: NEUROREPORT
发表日期: 2000-03-20
卷: 11, 期:4, 页:737-741
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PAIN
英文摘要:

It is now well established that nerve growth factor (NGF) plays a key role in inflammation-induced hyperalgesia. It was also reported that brain derived neurotrophic factor (BDNF), another member of neurotrophins, contributed to the pain pathway as a neurotransmitter in the CNS. The present work demonstrated a down-regulation of glial cell line-derived neurotrophic factor (GDNF) mRNA expression in dorsal spinal cord in complete Freund′s adjuvant-induced unilateral arthritic rats serving as a chronic pain model. The fast occurring and long lasting down-regulations suggest that GDNF might contribute to pain pathway in a way different from neurotrophins and might play a role in the maintenance of chronic pain status. NeuroReport 11:737-741 (C) 2000 Lippincott Williams & Wilkins.

语种: 英语
WOS记录号: WOS:000086083200022
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55373
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Fang, M,Wang, Y,Liu, HX,et al. Decreased GDNF mRNA expression in dorsal spinal cord of unilateral arthritic rat[J]. NEUROREPORT,2000,11(4):737-741.
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