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Effects of Avena nuda L. on metabolic control and cardiovascular disease risk among Chinese patients with diabetes and meeting metabolic syndrome criteria: secondary analysis of a randomized clinical trial
Ma, X.; Gu, J.; Zhang, Z.; Jing, L.; Xu, M.; Dai, X.; Jiang, Y.; Li, Y.; Bao, L.; Cal, X.; Ding, Y.; Wang, J.; Li, Y.; Li, Y.
关键词Cardiovascular Disease Cereals Diabetes Mellitus Type 2 Metabolic Syndrome x
刊名EUROPEAN JOURNAL OF CLINICAL NUTRITION
2013-12-01
DOI10.1038/ejcn.2013.201
67期:12页:1291-1297
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]CORONARY-HEART-DISEASE ; OAT BETA-GLUCAN ; WHOLE-GRAIN ; INSULIN SENSITIVITY ; LDL CHOLESTEROL ; SERUM-LIPIDS ; WOMEN ; FIBER ; BRAN ; ADULTS
英文摘要

BACKGROUND/OBJECTIVES: Most patients with Tyke 2 diabetes mellitus(DM) also have metabolic syndrome (MetS), which is associated with an increased risk of coronary heart disease prevalence. Limited information is available on the effect and effective doses of oat intake with a structured dietary intervention in metabolic control and cardiovascular disease (CVD) risk prevention with the population who has Type 2 DM and meets the MetS criteria.

SUBJECTS/METHODS: A total of 260 Type 2 DM patients meeting MetS National Cholesterol Education Program Adult Treatment Panel III criteria were selected from 445 patients between 50 and 65 years of age, and they participated in a single-blinded, 30-day centralized management of a dietary program in China. Participants in the program were randomly assigned into one of the four groups: usual care group (control group, only basic health advice), diet group (systematic diet plans and intensive education), 50 gorganic naked oat with whole germ group (ONOG) and 100 g-organic naked oat with whole germ group (daily ONOG replacement boiled into porridge based on diet group). The primary outcomes were the relative changes in glycosylated hemoglobin (HbA1c) and insulin resistance after a 30-day intervention among the four groups.

RESULTS: HbA1c decreased significantly with the increase in interventions (P-trend <0.05). Similar results were also obtained in plasma glucose, serum lipid and hypersensitive C-reactive protein (hs-CRP). For the 100 g-ONOG group but not 50 g-ONOG group, HbA1c and hs-CRP reduced significantly by 0.51% and 1.29 mg/l (P<0.05, vs diet group), respectively. The 100 g-ONOG group showed a reduction by 0.22 U*mol/l(2) in insulin resistance, compared with the 50 g-ONOG group (P =0.039).

CONCLUSIONS: Compared with diet alone or no diet, 50-100 g/day ONOG supplement to structured dietary intervention, at a dose of 100 g/day especially, contributes to the Type 2 DM patients meeting MetS criteria in their metabolic control and CVD risk prevention, with external factors being controlled.

语种英语
WOS记录号WOS:000327925600010
资助机构Inner Mongolia Sanzhuliang Natural Oats Industry Corporation
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55379
专题北京大学公共卫生学院
北京大学临床肿瘤学院_药剂科
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位Peking Univ, Dept Nutr & Food Hyg, Sch Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Ma, X.,Gu, J.,Zhang, Z.,et al. Effects of Avena nuda L. on metabolic control and cardiovascular disease risk among Chinese patients with diabetes and meeting metabolic syndrome criteria: secondary analysis of a randomized clinical trial[J]. EUROPEAN JOURNAL OF CLINICAL NUTRITION,2013,67(12):1291-1297.
APA Ma, X..,Gu, J..,Zhang, Z..,Jing, L..,Xu, M..,...&Li, Y..(2013).Effects of Avena nuda L. on metabolic control and cardiovascular disease risk among Chinese patients with diabetes and meeting metabolic syndrome criteria: secondary analysis of a randomized clinical trial.EUROPEAN JOURNAL OF CLINICAL NUTRITION,67(12),1291-1297.
MLA Ma, X.,et al."Effects of Avena nuda L. on metabolic control and cardiovascular disease risk among Chinese patients with diabetes and meeting metabolic syndrome criteria: secondary analysis of a randomized clinical trial".EUROPEAN JOURNAL OF CLINICAL NUTRITION 67.12(2013):1291-1297.
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